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protein coding gene - ria1 (SPCC553.08c) - GTPase Ria1

Gene summary

Standard name
ria1
Systematic ID
SPCC553.08c
Product
GTPase Ria1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74945
ORFeome ID
30/30A08
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 289880..293230 forward strand

Annotation

Disease association

MONDO:0044205 - Shwachman-Diamond syndrome 2

References:

GO biological process

GO:0042254 - ribosome biogenesis

References:

GO cellular component

GO:0005829 - cytosol

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GO molecular function

GO:0005525 - GTP binding

References:

GO:0003924 - GTPase activity

References:

GO:0043022 - ribosome binding

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003625 - abnormal microtubule cytoskeleton morphology during mitotic interphase

References:

Genotypes:

FYPO:0000121 - abnormal sporulation

References:

Genotypes:

FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0001390 - misoriented septum during vegetative growth

References:

Genotypes:

FYPO:0003717 - normal actin cytoskeleton morphology during vegetative growth

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Genotypes:

FYPO:0003595 - S-shaped cell

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Genotypes:

FYPO:0004325 - sensitive to 5-fluorouracil

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0002112 - viable curved vegetative cell

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002197 - viable vegetative cell with abnormal cell shape

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF25118EFL1EFL1PFAM
PF00679EFG_CEFG_V-likePFAM
PF00009GTP_EFTUT_Tr_GTP-bd_domPFAM
PF14492EFG_IIIEFG_IIPFAM
cd01681aeEF2_snRNP_like_IVCDD
cd04096eEF2_snRNP_like_CCDD
cd01885EF2CDD
cd16268EF2_IICDD
cd16261EF2_snRNP_IIICDD
PS51722G_TR_2T_Tr_GTP-bd_domPROSITE_PROFILES
SM00838EFG_C_aEFG_V-likeSMART
PR00315ELONGATNFCTT_Tr_GTP-bd_domPRINTS
G3DSA:3.30.70.870:FF:000002FUNFAM
G3DSA:3.30.70.240:FF:000006FUNFAM
G3DSA:3.40.50.300:FF:000746FUNFAM
G3DSA:3.90.1430.10:FF:000002FUNFAM
SSF54980EF-G C-terminal domain-likeEFG_III/VSUPERFAMILY
SSF50447Translation proteinsTransl_B-barrel_sfSUPERFAMILY
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
SSF54211Ribosomal protein S5 domain 2-likeRibosomal_Su5_D2-typ_SFSUPERFAMILY
G3DSA:3.30.70.240GENE3D
G3DSA:3.30.70.870Elongation Factor G (Translational Gtpase), domain 3GENE3D
G3DSA:3.30.230.10Ribsml_uS5_D2-typ_fold_subgrGENE3D
G3DSA:2.40.30.10Translation factorsGENE3D
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
PTHR42908TRANSLATION ELONGATION FACTOR-RELATEDPANTHER
CoilCoilCOILS
TIGR00231small_GTPSmall_GTP-bdNCBIFAM

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:32101745 - Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.
Lee SY et al. Cell Rep 2020 Feb 25;30(8):2686-2698.e8
PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.
Han TX et al. Genome Biol 2010;11(6):R60
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
Sun LL et al. PLoS Genet 2013;9(8):e1003715
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000002 - Comments
PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.
Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:25210736 - Dynamics of cell shape inheritance in fission yeast.
Abenza JF et al. PLoS One 2014;9(9):e106959
PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.
Materne P et al. Elife 2015 Jun 22;4:e09008
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.
Mojardín L et al. Cell Cycle 2015;14(2):206-18