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protein coding gene - knh3 (SPCC553.10) - conserved fungal cell surface protein, Kre9/Knh1 family, Knh3

Gene summary

Standard name
knh3
Systematic ID
SPCC553.10
Product
conserved fungal cell surface protein, Kre9/Knh1 family, Knh3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74947
ORFeome ID
16/16A08
Characterisation status
conserved unknown
Feature type
mRNA gene
Genomic location
chromosome III: 283181..285047 reverse strand

Annotation

GO cellular component

GO:0009897 - external side of plasma membrane

References:

Modification

MOD:00818 - glycosylphosphatidylinositolated residue

References:

MOD:01148 - ubiquitinylated lysine

References:

Protein sequence feature

SO:0000418 - signal_peptide

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF10342Kre9_KNHKre9/Knh1-like_NPfam
PTHR35185PANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMobiDB-Low-complexity
Signal PeptideSignal-Peptide-DeepTMHMM

Orthologs

References / Literature

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000007 - Prediction of GPI-anchored proteins with pointer neural networks
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:12845604 - Genome-wide identification of fungal GPI proteins.
De Groot PW et al. Yeast 2003 Jul 15;20(9):781-96
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)