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protein coding gene - toa2 (SPCC553.11c) - transcription factor TFIIA complex small subunit Toa2

Gene summary

Standard name
toa2
Systematic ID
SPCC553.11c
Product
transcription factor TFIIA complex small subunit Toa2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74948
ORFeome ID
05/05A06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 281854..283213 forward strand

Annotation

GO biological process

GO:0060963 - positive regulation of ribosomal protein gene transcription by RNA polymerase II

References:

GO:0051123 - RNA polymerase II preinitiation complex assembly

References:

GO:0006367 - transcription initiation at RNA polymerase II promoter

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO:0005672 - transcription factor TFIIA complex

References:

GO molecular function

GO:0016251 - RNA polymerase II general transcription initiation factor activity

References:

GO:0017025 - TBP-class protein binding

References:

Modification

MOD:00006 - N-glycosylated residue

References:

MOD:01148 - ubiquitinylated lysine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002451 - inviable vegetative cell with abnormal cell shape

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF02268TFIIA_gamma_NTFIIA_gsu_NPfam
PF02751TFIIA_gamma_CTFIIA_gsu_CPfam
cd10014TFIIA_gamma_CTFIIA_gsu_CCDD
cd10145TFIIA_gamma_NTFIIA_gsu_NCDD
G3DSA:1.10.287.190:FF:000001CATH-FunFam
G3DSA:2.30.18.10:FF:000003CATH-FunFam
G3DSA:1.10.287.190TFIIA_a-hlxCATH-Gene3D
G3DSA:2.30.18.10TFIIA_b-brlCATH-Gene3D
SSF47396SUPERFAMILY
SSF50784TFIIA_b-brlSUPERFAMILY
PTHR10966TFIIA_gsuPANTHER
PIRSF009415Hum_TFIIA_gammaTFIIA_gsuPIRSF

Orthologs

References / Literature

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:28060464 - RNA polymerase II components and Rrn7 form a preinitiation complex on the HomolD box to promote ribosomal protein gene expression in Schizosaccharomyces pombe.
Montes M et al. FEBS J 2017 Feb;284(4):615-633
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7