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protein coding gene - SPCC576.06c - mitochondrial tyrosine-tRNA ligase

Gene summary

Systematic ID
SPCC576.06c
Product
mitochondrial tyrosine-tRNA ligase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74890
ORFeome ID
23/23B09
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 2092017..2093637 reverse strand

Annotation

PBO:0005195 - 6.1.1.1

Disease association

MONDO:0013307 - myopathy, lactic acidosis, and sideroblastic anemia 2

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0003723 - RNA binding

References:

GO:0004831 - tyrosine-tRNA ligase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00579tRNA-synt_1baa-tRNA-synth_IcPfam
cd00805TyrRS_coreTyr-tRNA-ligaseCDD
PS00178AA_TRNA_LIGASE_Iaa-tRNA-synth_I_CSPROSITE patterns
PS50889S4PROSITE profiles
PR01040TRNASYNTHTYRTyr-tRNA-ligasePRINTS
G3DSA:1.10.240.10:FF:000001CATH-FunFam
G3DSA:3.40.50.620:FF:000287CATH-FunFam
G3DSA:1.10.240.10CATH-Gene3D
G3DSA:3.10.290.10S4_RNA-bd_sfCATH-Gene3D
G3DSA:3.40.50.620Rossmann-like_a/b/a_foldCATH-Gene3D
SSF52374SUPERFAMILY
SSF55174SUPERFAMILY
PTHR11766Tyr-tRNA-ligase_bac-typePANTHER
TIGR00234tyrSTyr-tRNA-ligaseNCBIFAM

Orthologs

References / Literature

GO_REF:0000002 - Comments
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531