protein coding gene - ksg1 (SPCC576.15c) - phosphoinositide-dependent protein kinase Ksg1

Gene summary

Standard name

ksg1

Systematic ID

SPCC576.15c

Product

phosphoinositide-dependent protein kinase Ksg1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q12701

ORFeome ID

26/26E01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 2103938..2106290 reverse strand

Annotation

Protein features

Orthologs

• PDPK1 (HGNC:8816) Homo sapiens
• ksg1 (SJAG_02468) Schizosaccharomyces japonicus
• PKH1 (YDR490C) Saccharomyces cerevisiae
• PKH2 (YOL100W) Saccharomyces cerevisiae

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:25411338 - Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.

Saitoh S et al. Mol Biol Cell 2015 Jan 15;26(2):373-86

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:22976295 - Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase.

Nakashima A et al. J Cell Sci 2012 Dec 01;125(Pt 23):5840-9

PMID:15611161 - In vivo activation of protein kinase A in Schizosaccharomyces pombe requires threonine phosphorylation at its activation loop and is dependent on PDK1.

Tang Y et al. Genetics 2004 Dec;168(4):1843-53

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:28536259 - Differential functional regulation of protein kinase C (PKC) orthologs in fission yeast.

Madrid M et al. J Biol Chem 2017 Jul 07;292(27):11374-11387

PMID:12805221 - Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases.

Matsuo T et al. EMBO J 2003 Jun 16;22(12):3073-83

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:10071224 - A Schizosaccharomyces pombe gene, ksg1, that shows structural homology to the human phosphoinositide-dependent protein kinase PDK1, is essential for growth, mating and sporulation.

Niederberger C et al. Mol Gen Genet 1999 Feb;261(1):177-83

PMID:41184513 - Phosphorylation-dependent tuning of mRNA deadenylation rates.

Stowell JAW et al. Nat Struct Mol Biol 2025 Nov 03;

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:31072933 - Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation.

Xu X et al. Proc Natl Acad Sci U S A 2019 May 28;116(22):10889-10898

PMID:25416816 - Multiple layers of regulation influence cell integrity control by the PKC ortholog Pck2 in fission yeast.

Madrid M et al. J Cell Sci 2015 Jan 15;128(2):266-80

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:15249580 - A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast.

Mitra P et al. J Cell Biol 2004 Jul 19;166(2):205-11

PMID:35082773 - Phosphoinositide-Dependent Protein Kinases Regulate Cell Cycle Progression Through the SAD Kinase Cdr2 in Fission Yeast.

Liu K et al. Front Microbiol 2021;12:807148

PMID:34534388 - Identification of ksg1 mutation showing long-lived phenotype in fission yeast.

Matsui K et al. Genes Cells 2021 Dec;26(12):967-978

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:14625898 - Ksg1, a homologue of the phosphoinositide-dependent protein kinase 1, controls cell wall integrity in Schizosaccharomyces pombe.

Gräub R et al. J Basic Microbiol 2003;43(6):473-82

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:24247430 - Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition.

Hálová L et al. J Cell Biol 2013 Nov 25;203(4):595-604

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87