protein coding gene - yip1 (SPCC61.04c) - ER exit site selective cargo-gating component coupled to Erv29

Gene summary

Standard name: yip1
Systematic ID: SPCC61.04c
Product: ER exit site selective cargo-gating component coupled to Erv29
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O94348
ORFeome ID: 15/15F10
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome III: 1446214..1447572 reverse strand

Annotation

Disease association

MONDO:0025690 - microcephaly, epilepsy, and diabetes syndrome 2

References:

PB_REF:0000006

GO biological process

GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport

References:

GO_REF:0000033

GO:0048280 - vesicle fusion with Golgi apparatus

References:

GO_REF:0000033

GO cellular component

GO:0070971 - endoplasmic reticulum exit site

References:

PMID:41717013

GO:0016020 - membrane

References:

GO_REF:0000002

GO:0005802 - trans-Golgi network

References:

GO_REF:0000033

Protein features

PBO:0111776 - Yip1 family

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

PMID:11152613

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PMID:31626996

Quantitative gene expression

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

yip1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

yip1delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

ID	Name	InterPro name	DB name
PF04893	Yip1	Yip1_dom	Pfam
PTHR21236		Yip1/4-like	PANTHER
Transmembrane alpha helix			DeepTMHMM

Orthologs

YIPF5 (HGNC:24877) Homo sapiens
YIPF7 (HGNC:26825) Homo sapiens
yip1 (SJAG_03670) Schizosaccharomyces japonicus
YIP1 (YGR172C) Saccharomyces cerevisiae

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000002 - Comments
PMID:41717013 - The microcephaly-associated protein YIPF5 differentially regulates ER export.: Bruno F et al. iScience 2026 Feb 20;29(2):114791
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.: Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.: Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.: Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83