protein coding gene - rng3 (SPCC613.04c) - UCS-domain protein Rng3

Gene summary

Standard name

rng3

Systematic ID

SPCC613.04c

Product

UCS-domain protein Rng3

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O74994

ORFeome ID

28/28A06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 86164..88688 reverse strand

Annotation

Protein features

Orthologs

• UNC45B (HGNC:14304) Homo sapiens
• UNC45A (HGNC:30594) Homo sapiens
• rng3 (SJAG_00750) Schizosaccharomyces japonicus
• SHE4 (YOR035C) Saccharomyces cerevisiae

References / Literature

PMID:24244528 - UCS protein Rng3p is essential for myosin-II motor activity during cytokinesis in fission yeast.

Stark BC et al. PLoS One 2013;8(11):e79593

PMID:18272786 - Pxl1p, a paxillin-related protein, stabilizes the actomyosin ring during cytokinesis in fission yeast.

Ge W et al. Mol Biol Cell 2008 Apr;19(4):1680-92

PMID:30201262 - Fission yeast Adf1 is necessary for reassembly of actin filaments into the contractile ring during cytokinesis.

Ueda EI et al. Biochem Biophys Res Commun 2018 Nov 25;506(2):330-338

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:16224022 - Counting cytokinesis proteins globally and locally in fission yeast.

Wu JQ et al. Science 2005 Oct 14;310(5746):310-4

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:10545452 - Drc1p/Cps1p, a 1,3-beta-glucan synthase subunit, is essential for division septum assembly in Schizosaccharomyces pombe.

Liu J et al. Genetics 1999 Nov;153(3):1193-203

PMID:15504913 - UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II.

Lord M et al. J Cell Biol 2004 Oct 25;167(2):315-25

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:9649519 - Isolation and characterization of new fission yeast cytokinesis mutants.

Balasubramanian MK et al. Genetics 1998 Jul;149(3):1265-75

PMID:28808035 - Fission yeast myosin Myo2 is down-regulated in actin affinity by light chain phosphorylation.

Pollard LW et al. Proc Natl Acad Sci U S A 2017 Aug 29;114(35):E7236-E7244

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:19098712 - Rng3, a member of the UCS family of myosin co-chaperones, associates with myosin heavy chains cotranslationally.

Amorim MJ et al. EMBO Rep 2009 Feb;10(2):186-91

PMID:15755919 - Hsp90 protein in fission yeast Swo1p and UCS protein Rng3p facilitate myosin II assembly and function.

Mishra M et al. Eukaryot Cell 2005 Mar;4(3):567-76

PMID:15537703 - The nuclear kinase Lsk1p positively regulates the septation initiation network and promotes the successful completion of cytokinesis in response to perturbation of the actomyosin ring in Schizosaccharomyces pombe.

Karagiannis J et al. Mol Biol Cell 2005 Jan;16(1):358-71

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:12725728 - The UCS domain protein She4p binds to myosin motor domains and is essential for class I and class V myosin function.

Wesche S et al. Curr Biol 2003 Apr 29;13(9):715-24

PMID:23770677 - In vitro contraction of cytokinetic ring depends on myosin II but not on actin dynamics.

Mishra M et al. Nat Cell Biol 2013 Jul;15(7):853-9

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:10852821 - Fission yeast Rng3p: an UCS-domain protein that mediates myosin II assembly during cytokinesis.

Wong KC et al. J Cell Sci 2000 Jul;113 ( Pt 13):2421-32

PMID:33506191 - Escape from mitotic catastrophe by actin-dependent nuclear displacement in fission yeast.

Yukawa M et al. iScience 2021 Jan 22;24(1):102031

PMID:19279143 - Role of the RNA-binding protein Nrd1 and Pmk1 mitogen-activated protein kinase in the regulation of myosin mRNA stability in fission yeast.

Satoh R et al. Mol Biol Cell 2009 May;20(9):2473-85