protein coding gene - hta1 (SPCC622.08c) - histone H2A alpha

Gene summary

Standard name

hta1

Systematic ID

SPCC622.08c

Product

histone H2A alpha

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P04909

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 1411144..1412181 reverse strand

Annotation

Protein features

Orthologs

• H2AC12 (HGNC:13671) Homo sapiens
• H2AB3 (HGNC:14455) Homo sapiens
• H2AJ (HGNC:14456) Homo sapiens
• H2AB2 (HGNC:18298) Homo sapiens
• H2AC1 (HGNC:18729) Homo sapiens
• H2AC25 (HGNC:20507) Homo sapiens
• H2AC21 (HGNC:20508) Homo sapiens
• H2AB1 (HGNC:22516) Homo sapiens
• H2AC8 (HGNC:4724) Homo sapiens
• H2AC13 (HGNC:4725) Homo sapiens
• H2AC15 (HGNC:4726) Homo sapiens
• H2AC14 (HGNC:4727) Homo sapiens
• H2AC16 (HGNC:4730) Homo sapiens
• H2AC6 (HGNC:4733) Homo sapiens
• H2AC4 (HGNC:4734) Homo sapiens
• H2AC17 (HGNC:4735) Homo sapiens
• H2AC11 (HGNC:4737) Homo sapiens
• H2AX (HGNC:4739) Homo sapiens
• hta1 (SJAG_03942) Schizosaccharomyces japonicus
• HTA2 (YBL003C) Saccharomyces cerevisiae
• HTA1 (YDR225W) Saccharomyces cerevisiae

References / Literature

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:29769606 - Malonylation of histone H2A at lysine 119 inhibits Bub1-dependent H2A phosphorylation and chromosomal localization of shugoshin proteins.

Ishiguro T et al. Sci Rep 2018 May 16;8(1):7671

PMID:30348841 - Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress.

Oravcová M et al. Mol Cell Biol 2019 Jan 15;39(2)

PMID:19443688 - Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast.

Fischer T et al. Proc Natl Acad Sci U S A 2009 Jun 02;106(22):8998-9003

PMID:26160178 - Dimerization Mediated by a Divergent Forkhead-associated Domain Is Essential for the DNA Damage and Spindle Functions of Fission Yeast Mdb1.

Luo S et al. J Biol Chem 2015 Aug 21;290(34):21054-21066

PMID:23231582 - Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe.

Carter-O'Connell I et al. BMC Genomics 2012 Dec 12;13:697

PMID:22235339 - The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia.

Lando D et al. PLoS One 2012;7(1):e29765

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

GO_REF:0000002 - Comments

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.

Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:23656778 - Brc1 links replication stress response and centromere function.

Lee SY et al. Cell Cycle 2013 Jun 01;12(11):1665-71

PMID:24806815 - Mdb1, a fission yeast homolog of human MDC1, modulates DNA damage response and mitotic spindle function.

Wei Y et al. PLoS One 2014;9(5):e97028

PMID:22426534 - DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase.

Sabouri N et al. Genes Dev 2012 Mar 15;26(6):581-93

PMID:38971312 - TORC2 is required for accumulation of γH2A in response to DNA damage.

Cohen A et al. J Biol Chem 2024 Jul 04;:107531

PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Pan X et al. BMC Genomics 2012 Nov 23;13:662

PMID:20679485 - BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint.

Sofueva S et al. Mol Cell Biol 2010 Oct;30(19):4732-43

PMID:16540522 - Nuclear RanGAP is required for the heterochromatin assembly and is reciprocally regulated by histone H3 and Clr4 histone methyltransferase in Schizosaccharomyces pombe.

Nishijima H et al. Mol Biol Cell 2006 Jun;17(6):2524-36

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:23658229 - Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.

Sugiyama T et al. Nucleic Acids Res 2013 Jul;41(13):6674-86

PMID:41453208 - Cnp1 N-terminal dynamics regulate L1 loop recognition by Mis15 to orchestrate kinetochore assembly in Schizosaccharomyces pombe.

Xiong Y et al. J Mol Cell Biol 2025 Dec 26;

PMID:20094029 - gammaH2A binds Brc1 to maintain genome integrity during S-phase.

Williams JS et al. EMBO J 2010 Mar 17;29(6):1136-48

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:18676809 - Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair.

Kilkenny ML et al. Genes Dev 2008 Aug 01;22(15):2034-47

PMID:19111658 - HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.

Motamedi MR et al. Mol Cell 2008 Dec 26;32(6):778-90

PMID:19714215 - The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.

Aligianni S et al. PLoS Genet 2009 Aug;5(8):e1000626

PMID:21633354 - Condensin association with histone H2A shapes mitotic chromosomes.

Tada K et al. Nature 2011 Jun 01;474(7352):477-83

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:15226425 - Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.

Nakamura TM et al. Mol Cell Biol 2004 Jul;24(14):6215-30

PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.

Mak T et al. EMBO J 2021 Aug 16;40(16):e107911

PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.

Vega M et al. BMC Biol 2022 Jul 12;20(1):160

PMID:26804021 - Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.

Tashiro S et al. Nat Commun 2016 Jan 25;7:10393

PMID:25002536 - A novel histone deacetylase complex in the control of transcription and genome stability.

Zilio N et al. Mol Cell Biol 2014 Sep 15;34(18):3500-14

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:16314498 - Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast.

Nakamura TM et al. Mol Cell Biol 2005 Dec;25(24):10721-30

PMID:20679488 - Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation.

Sanders SL et al. Mol Cell Biol 2010 Oct;30(19):4722-31

PMID:40594858 - Dbl2 interacts with helicases and an endonuclease to maintain the integrity of repetitive regions.

Bakosova A et al. Sci Rep 2025 Jul 01;15(1):21895

PMID:23080121 - Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.

Limbo O et al. Nucleic Acids Res 2012 Dec;40(22):11435-49

PMID:19965387 - Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin.

Kawashima SA et al. Science 2010 Jan 08;327(5962):172-7

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:27901072 - Characterisation of functional domains in fission yeast Ams2 that are required for core histone gene transcription.

Takayama Y et al. Sci Rep 2016 Nov 30;6:38111

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:26368543 - Critical Function of γH2A in S-Phase.

Mejia-Ramirez E et al. PLoS Genet 2015 Sep;11(9):e1005517

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:25795664 - Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants.

Sánchez A et al. G3 (Bethesda) 2015 Mar 19;5(5):953-62

PMID:28784724 - Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase.

Reubens MC et al. Mol Cell Biol 2017 Nov 15;37(22)

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Anver S et al. EMBO Rep 2014 Aug;15(8):894-902

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:20929775 - Two histone marks establish the inner centromere and chromosome bi-orientation.

Yamagishi Y et al. Science 2010 Oct 08;330(6001):239-43

PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.

Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:38048463 - Rex1BD and the 14-3-3 protein control heterochromatin organization at tandem repeats by linking RNAi and HDAC.

Gao J et al. Proc Natl Acad Sci U S A 2023 Dec 12;120(50):e2309359120

PMID:33670267 - The Role of Non-Catalytic Domains of Hrp3 in Nucleosome Remodeling.

Dong W et al. Int J Mol Sci 2021 Feb 11;22(4)

PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:16778077 - Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.

Du LL et al. Genes Dev 2006 Jun 15;20(12):1583-96

PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Liu NN et al. Cell Res 2010 Aug;20(8):963-5

PMID:20661445 - Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast.

Rozenzhak S et al. PLoS Genet 2010 Jul 22;6(7):e1001032

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:21098122 - Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks.

Limbo O et al. Mol Cell Biol 2011 Feb;31(3):573-83

PMID:20230746 - Hsk1- and SCF(Pof3)-dependent proteolysis of S. pombe Ams2 ensures histone homeostasis and centromere function.

Takayama Y et al. Dev Cell 2010 Mar 16;18(3):385-96