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protein coding gene - tti1 (SPCC622.13c) - TTT co-chaperone complex, armadillo-type fold subunit Tti1

Gene summary

Standard name
tti1
Systematic ID
SPCC622.13c
Product
TTT co-chaperone complex, armadillo-type fold subunit Tti1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94600
ORFeome ID
48/48B09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1421146..1425867 reverse strand

Annotation

Disease association

MONDO:0957531 - neurodevelopmental disorder with microcephaly and movement abnormalities

References:

GO biological process

GO:0051083 - 'de novo' cotranslational protein folding

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0110078 - TTT Hsp90 cochaperone complex

References:

GO molecular function

GO:0030674 - protein-macromolecule adaptor activity

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Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

Protein features

PBO:0111765 - HEAT repeat

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0002133 - abolished protein-RNA interaction

References:

Genotypes:

FYPO:0003827 - decreased ribosomal S6 protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0000780 - increased transcription during vegetative growth

References:

Genotypes:

FYPO:0002430 - inviable after spore germination, multiple cell divisions

References:

Genotypes:

FYPO:0000951 - inviable small vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF24181TPR_TTI1_CTPR_TTI1_CPFAM
PF24173TPR_TTI1_NTPR_TTI1_NPFAM
PF21547TTI1TTI1_rptPFAM
PF26245TPR_TTI1_2nd_yeastTPR_TTI1_2nd_yeastPFAM
SSF48371ARM repeatARM-type_foldSUPERFAMILY
PTHR18460TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBERTELO2-interacting_protein_1PANTHER
PIRSF005250UCP005250Tti1PIRSF
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:18076573 - Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.
Hayashi T et al. Genes Cells 2007 Dec;12(12):1357-70
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:21642955 - Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.
Helmlinger D et al. EMBO J 2011 Jun 03;30(14):2843-52
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:34686329 - The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKKs prior to complex assembly.
Toullec D et al. Cell Rep 2021 Oct 19;37(3):109867
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:31332096 - A tel2 Mutation That Destabilizes the Tel2-Tti1-Tti2 Complex Eliminates Rad3 ATR Kinase Signaling in the DNA Replication Checkpoint and Leads to Telomere Shortening in Fission Yeast.
Xu YJ et al. Mol Cell Biol 2019 Oct 15;39(20)
PMID:31748520 - Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast.
Elías-Villalobos A et al. Nat Commun 2019 Nov 20;10(1):5237
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:27935167 - CK2 phospho-independent assembly of the Tel2-associated stress-signaling complexes in Schizosaccharomyces pombe.
Inoue H et al. Genes Cells 2017 Jan;22(1):59-70
PMID:20801936 - Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.
Takai H et al. Genes Dev 2010 Sep 15;24(18):2019-30