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protein coding gene - epe1 (SPCC622.16c) - histone demethylase-like, Jmjc domain Epe1

Gene summary

Standard name
epe1
Systematic ID
SPCC622.16c
Product
histone demethylase-like, Jmjc domain Epe1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
kdm2
UniProt ID
O94603
ORFeome ID
29/29E12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1431048..1435041 reverse strand

Annotation

Disease association

MONDO:0980965 - neurodevelopmental disorder with congenital cardiac defects and variable renal and ocular abnormalities

References:

MONDO:0010286 - syndromic X-linked intellectual disability Siderius type

References:

GO biological process

GO:0033696 - heterochromatin boundary formation

References:

GO:0010964 - regulation of regulatory ncRNA-mediated heterochromatin formation

References:

GO:1902801 - regulation of siRNA-independent facultative heterochromatin formation

References:

GO cellular component

GO:0000792 - heterochromatin

References:

GO:1990342 - heterochromatin island

References:

GO:0031934 - mating-type region heterochromatin

References:

GO:0005634 - nucleus

References:

GO:0005721 - pericentric heterochromatin

References:

GO:0140720 - subtelomeric heterochromatin

References:

GO molecular function

GO:0051864 - histone H3K36 demethylase activity

References:

GO:0141052 - histone H3 demethylase activity

References:

Genome organisation

PBO:0000359 - antisense transcript detected

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

MOD:01149 - sumoylated lysine

References:

Multi-locus phenotype

FYPO:0007477 - abnormal epigenetic heterochromatin inheritance

References:

Genotypes:

FYPO:0005844 - abolished histone H3-K9 trimethylation at silent mating-type cassette during vegetative growth

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0003411 - decreased chromatin silencing at centromere inner repeat

References:

Genotypes:

FYPO:0006993 - decreased chromatin silencing at centromere otr1R

References:

Genotypes:

FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

References:

Genotypes:

FYPO:0002827 - decreased chromatin silencing at silent mating-type cassette

References:

Genotypes:

FYPO:0004604 - decreased chromatin silencing at subtelomere

References:

Genotypes:

FYPO:0007478 - decreased epigenetic heterochromatin inheritance

References:

Genotypes:

FYPO:0005922 - decreased heterochromatin assembly at subtelomere

References:

Genotypes:

FYPO:0001458 - decreased histone H3-K14 acetylation during vegetative growth

References:

Genotypes:

FYPO:0007217 - decreased histone H3-K9 acetylation at protein coding gene during vegetative growth

References:

Genotypes:

FYPO:0000888 - decreased histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0002355 - decreased histone H3-K9 dimethylation at silent mating-type cassette during vegetative growth

References:

Genotypes:

FYPO:0004137 - decreased histone H3-K9 dimethylation at subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0000890 - decreased histone H3-K9 trimethylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

References:

Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

References:

Genotypes:

FYPO:0001798 - decreased translation

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0003045 - heterochromatin assembly beyond boundary element IRC1R

References:

Genotypes:

FYPO:0007339 - increased cen-dg RNA level

References:

Genotypes:

FYPO:0000220 - increased centromeric outer repeat transcript level

References:

Genotypes:

FYPO:0004540 - increased chromatin silencing

References:

Genotypes:

FYPO:0006994 - increased chromatin silencing at centromere otr1L

References:

Genotypes:

FYPO:0004544 - increased duration of heterochromatin maintenance

References:

Genotypes:

FYPO:0000577 - increased gene silencing

References:

Genotypes:

FYPO:0000887 - increased histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0006268 - increased histone H3-K9 dimethylation at protein coding gene during vegetative growth

References:

Genotypes:

FYPO:0000873 - increased histone H3-K9 dimethylation during vegetative growth

References:

Genotypes:

FYPO:0003102 - increased histone H3-K9 methylation at protein coding gene during vegetative growth

References:

Genotypes:

FYPO:0008327 - increased histone H3-K9 trimethylation at heterochromatin island during vegetative growth

References:

Genotypes:

FYPO:0008326 - increased histone H3-K9 trimethylation at protein coding gene during vegetative growth

References:

Genotypes:

FYPO:0004237 - increased protein localization to heterochromatin at centromere outer repeat region

References:

Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

References:

Genotypes:

FYPO:0006110 - increased silent mating-type cassette transcript-derived siRNA level

References:

Genotypes:

FYPO:0004749 - increased spatial extent of subtelomeric heterochromatin assembly

References:

Genotypes:

FYPO:0005917 - increased subtelomeric heterochromatin RNA level

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002335 - normal chromatin silencing

References:

Genotypes:

FYPO:0002360 - normal chromatin silencing at centromere

References:

Genotypes:

FYPO:0006995 - normal chromatin silencing at centromere inner repeat

References:

Genotypes:

FYPO:0006992 - normal chromatin silencing at centromere otr1R

References:

Genotypes:

FYPO:0002336 - normal chromatin silencing at silent mating-type cassette

References:

Genotypes:

FYPO:0007479 - normal epigenetic heterochromatin inheritance

References:

Genotypes:

FYPO:0000578 - normal gene silencing

References:

Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

References:

Genotypes:

FYPO:0001689 - normal growth on 4-nitroquinoline N-oxide

References:

Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

References:

Genotypes:

FYPO:0007074 - normal growth on mycophenolic acid

References:

Genotypes:

FYPO:0003574 - normal histone H3-K14 acetylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0003575 - normal histone H3-K9 acetylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0007220 - normal histone H3-K9 acetylation at protein coding gene during vegetative growth

References:

Genotypes:

FYPO:0004743 - normal histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0002358 - normal histone H3-K9 dimethylation at silent mating-type cassette during vegetative growth

References:

Genotypes:

FYPO:0006429 - normal histone H3-K9 dimethylation at subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0003235 - normal histone H3-K9 methylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0010075 - normal histone H3-K9 methylation at protein coding gene during vegetative growth

References:

Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0008154 - normal protein localization to centromeric heterochromatin

References:

Genotypes:

FYPO:0002389 - normal protein localization to heterochromatin at centromere outer repeat

References:

Genotypes:

FYPO:0001317 - normal RNA level during vegetative growth

References:

Genotypes:

FYPO:0005602 - normal subtelomeric heterochromatin RNA level

References:

Genotypes:

FYPO:0003503 - normal vegetative cell length

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0001098 - sensitive to 4-nitroquinoline N-oxide

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0003670 - sensitive to mycophenolic acid

References:

Genotypes:

FYPO:0002550 - sensitive to UV

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Protein features

PBO:0111833 - jmjC domain

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000027 - ribosomal density decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

PomGeneEx:0000013 - RNA level unchanged

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002346 - abnormal chromatin silencing at centromere outer repeat

References:

Genotypes:

FYPO:0000156 - abnormal chromatin silencing at silent mating-type cassette

References:

Genotypes:

FYPO:0007477 - abnormal epigenetic heterochromatin inheritance

References:

Genotypes:

FYPO:0005530 - abolished protein localization to chromatin at boundary element IRC1L

References:

Genotypes:

FYPO:0001132 - abolished protein localization to heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0006712 - decreased cellular acetyl-CoA level

References:

Genotypes:

FYPO:0004201 - decreased centromeric outer repeat transcript-derived siRNA level

References:

Genotypes:

FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

References:

Genotypes:

FYPO:0002827 - decreased chromatin silencing at silent mating-type cassette

References:

Genotypes:

FYPO:0004604 - decreased chromatin silencing at subtelomere

References:

Genotypes:

FYPO:0000303 - decreased conjugation frequency

References:

Genotypes:

FYPO:0007478 - decreased epigenetic heterochromatin inheritance

References:

Genotypes:

FYPO:0000877 - decreased histone H3-K9 dimethylation at centromere during vegetative growth

References:

Genotypes:

FYPO:0000890 - decreased histone H3-K9 trimethylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0005845 - decreased histone H3-K9 trimethylation at silent mating-type cassette during vegetative growth

References:

Genotypes:

FYPO:0005533 - decreased histone H4-K16 acetylation at boundary element IRC1L during vegetative growth

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0000450 - decreased protein localization to centromere during vegetative growth

References:

Genotypes:

FYPO:0002842 - decreased protein localization to centromere outer repeat

References:

Genotypes:

FYPO:0005531 - decreased protein localization to chromatin at boundary element IRC1L

References:

Genotypes:

FYPO:0003573 - decreased protein localization to heterochromatin at silent mating-type cassette

References:

Genotypes:

FYPO:0001514 - decreased protein localization to nucleus during vegetative growth

References:

Genotypes:

FYPO:0002386 - decreased protein localization to pericentric heterochromatin at centromere outer repeat region

References:

Genotypes:

FYPO:0006710 - decreased protein phosphorylation during cellular response to alkaline pH

References:

Genotypes:

FYPO:0002446 - decreased protein phosphorylation during cellular response to hydrogen peroxide

References:

Genotypes:

FYPO:0005749 - decreased protein phosphorylation during glucose starvation

References:

Genotypes:

FYPO:0001885 - decreased protein phosphorylation during salt stress

References:

Genotypes:

FYPO:0001645 - decreased protein-protein interaction

References:

Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

References:

Genotypes:

FYPO:0000584 - decreased sporulation frequency

References:

Genotypes:

FYPO:0002876 - decreased transcription

References:

Genotypes:

FYPO:0006012 - elongated cell with abolished shmoo formation

References:

Genotypes:

FYPO:0005286 - heterochromatin assembly beyond boundary element IRC1L

References:

Genotypes:

FYPO:0003045 - heterochromatin assembly beyond boundary element IRC1R

References:

Genotypes:

FYPO:0006985 - heterochromatin assembly beyond boundary element IRL

References:

Genotypes:

FYPO:0003938 - increased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0000636 - increased cell population growth rate

References:

Genotypes:

FYPO:0006714 - increased cellular free fatty acid level

References:

Genotypes:

FYPO:0006713 - increased cellular malonyl-CoA level

References:

Genotypes:

FYPO:0000220 - increased centromeric outer repeat transcript level

References:

Genotypes:

FYPO:0004541 - increased chromatin silencing at centromere inner repeat

References:

Genotypes:

FYPO:0004376 - increased chromatin silencing at silent mating-type cassette

References:

Genotypes:

FYPO:0004544 - increased duration of heterochromatin maintenance

References:

Genotypes:

FYPO:0000577 - increased gene silencing

References:

Genotypes:

FYPO:0001740 - increased gross chromosomal rearrangement

References:

Genotypes:

FYPO:0000966 - increased histone H3-K14 acetylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0005310 - increased histone H3-K14 acetylation during vegetative growth

References:

Genotypes:

FYPO:0004238 - increased histone H3-K4 acetylation during vegetative growth

References:

Genotypes:

FYPO:0006814 - increased histone H3-K9 acetylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0000892 - increased histone H3-K9 acetylation during vegetative growth

References:

Genotypes:

FYPO:0000887 - increased histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0006373 - increased histone H3-K9 dimethylation at heterochromatin island during vegetative growth

References:

Genotypes:

FYPO:0006361 - increased histone H3-K9 dimethylation at subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0000873 - increased histone H3-K9 dimethylation during vegetative growth

References:

Genotypes:

FYPO:0007469 - increased histone H3-K9 trimethylation during G0

References:

Genotypes:

FYPO:0000879 - increased histone H3-K9 trimethylation during vegetative growth

References:

Genotypes:

FYPO:0001859 - increased minichromosome loss

References:

Genotypes:

FYPO:0003009 - increased protein localization to centromere outer repeat

References:

Genotypes:

FYPO:0004237 - increased protein localization to heterochromatin at centromere outer repeat region

References:

Genotypes:

FYPO:0004689 - increased silent mating-type cassette cenH-derived RNA level

References:

Genotypes:

FYPO:0004948 - increased spatial extent of centromeric heterochromatin assembly

References:

Genotypes:

FYPO:0007953 - increased spatial extent of heterochromatin assembly

References:

Genotypes:

FYPO:0006990 - increased spatial extent of heterochromatin assembly at protein coding gene

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0000228 - lagging mitotic chromosomes

References:

Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0002335 - normal chromatin silencing

References:

Genotypes:

FYPO:0006995 - normal chromatin silencing at centromere inner repeat

References:

Genotypes:

FYPO:0006992 - normal chromatin silencing at centromere otr1R

References:

Genotypes:

FYPO:0002336 - normal chromatin silencing at silent mating-type cassette

References:

Genotypes:

FYPO:0007479 - normal epigenetic heterochromatin inheritance

References:

Genotypes:

FYPO:0007553 - normal G1 to G0 transition

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0000862 - normal histone H3-K9 dimethylation at centromere during vegetative growth

References:

Genotypes:

FYPO:0004743 - normal histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0002389 - normal protein localization to heterochromatin at centromere outer repeat

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0006991 - normal spatial extent of heterochromatin assembly at protein coding gene

References:

Genotypes:

FYPO:0000073 - resistance to caffeine

References:

Genotypes:

FYPO:0009079 - resistance to calcofluor and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0002693 - resistance to diamide

References:

Genotypes:

FYPO:0001453 - resistance to ethanol

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000852 - resistance to salt stress

References:

Genotypes:

FYPO:0005968 - resistance to sodium chloride

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0001098 - sensitive to 4-nitroquinoline N-oxide

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0001987 - sensitive to high pH

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002550 - sensitive to UV

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF02373JmjCJmjC_domPfam
PF17811JHDJHDPfam
PS51184JMJCJmjC_domPROSITE profiles
SM00558JmjCJmjC_domSMART
G3DSA:2.60.120.650CATH-Gene3D
SSF51197SUPERFAMILY
PTHR23123JHDM1_Histone_DemethylasePANTHER
CoilCOILS

Orthologs

References / Literature

PMID:41786738 - An H3K14ub-H3K9me3 feedback circuit governs heterochromatin spreading and inheritance in fission yeast.
Toda T et al. Nat Commun 2026 Mar 05;
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:25831549 - Epigenetics. Epigenetic inheritance uncoupled from sequence-specific recruitment.
Ragunathan K et al. Science 2015 Apr 03;348(6230):1258699
PMID:26988418 - The proper connection between shelterin components is required for telomeric heterochromatin assembly.
Wang J et al. Genes Dev 2016 Apr 01;30(7):827-39
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:36617881 - Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an antisilencing factor, Epe1, in fission yeast.
Asanuma T et al. Genes Dev 2022 Nov;36(21-24):1145-1159
PMID:17449867 - Interaction of Epe1 with the heterochromatin assembly pathway in Schizosaccharomyces pombe.
Isaac S et al. Genetics 2007 Apr;175(4):1549-60
PMID:29214404 - The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast.
Seo HD et al. Curr Genet 2018 Jun;64(3):741-752
PMID:27451393 - Role of Inner Nuclear Membrane Protein Complex Lem2-Nur1 in Heterochromatic Gene Silencing.
Banday S et al. J Biol Chem 2016 Sep 16;291(38):20021-9
PMID:32295063 - The Catalytic-Dependent and -Independent Roles of Lsd1 and Lsd2 Lysine Demethylases in Heterochromatin Formation in Schizosaccharomyces pombe .
Marayati BF et al. Cells 2020 Apr 13;9(4)
PMID:17948055 - The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin.
Trewick SC et al. EMBO J 2007 Nov 14;26(22):4670-82
PMID:25957277 - Intrinsic Toxicity of Unchecked Heterochromatin Spread Is Suppressed by Redundant Chromatin Boundary Functions in Schizosacchromyces pombe.
Garcia JF et al. G3 (Bethesda) 2015 May 08;5(7):1453-61
PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.
Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16
PMID:34731638 - The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states.
Murawska M et al. Cell Rep 2021 Nov 02;37(5):109944
PMID:33533152 - Functional interaction between ELL transcription elongation factor and Epe1 reveals the role of Epe1 in the regulation of transcription outside heterochromatin.
Sweta K et al. Mol Microbiol 2021 Jul;116(1):80-96
PMID:28784663 - The 19S proteasome is directly involved in the regulation of heterochromatin spreading in fission yeast.
Seo HD et al. J Biol Chem 2017 Oct 13;292(41):17144-17155
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.
Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15
PMID:38289024 - Heat stress-induced activation of MAPK pathway attenuates Atf1-dependent epigenetic inheritance of heterochromatin in fission yeast.
Sun L et al. Elife 2024 Jan 30;13
PMID:25972440 - Global regulation of heterochromatin spreading by Leo1.
Verrier L et al. Open Biol 2015 May;5(5)
PMID:26744419 - Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2.
Barrales RR et al. Genes Dev 2016 Jan 15;30(2):133-48
PMID:30652128 - Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription.
Okita AK et al. Commun Biol 2019;2:17
PMID:23604080 - HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin.
Aygün O et al. Nat Struct Mol Biol 2013 May;20(5):547-54
PMID:31598751 - Unprogrammed epigenetic variation mediated by stochastic formation of ectopic heterochromatin.
Sorida M et al. Curr Genet 2020 Apr;66(2):319-325
PMID:16362057 - Histone demethylation by a family of JmjC domain-containing proteins.
Tsukada Y et al. Nature 2006 Feb 16;439(7078):811-6
PMID:31206516 - Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1.
Sorida M et al. PLoS Genet 2019 Jun;15(6):e1008129
PMID:35171902 - The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly.
Bao K et al. PLoS Genet 2022 Feb;18(2):e1010049
PMID:26518661 - The Paf1 complex factors Leo1 and Paf1 promote local histone turnover to modulate chromatin states in fission yeast.
Sadeghi L et al. EMBO Rep 2015 Dec;16(12):1673-87
PMID:29899117 - Ccp1 modulates epigenetic stability at centromeres and affects heterochromatin distribution in Schizosaccharomyces pombe .
Lu M et al. J Biol Chem 2018 Aug 03;293(31):12068-12080
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.
Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
Sun LL et al. PLoS Genet 2013;9(8):e1003715
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:19443688 - Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast.
Fischer T et al. Proc Natl Acad Sci U S A 2009 Jun 02;106(22):8998-9003
PMID:21215368 - The Cul4-Ddb1(Cdt)² ubiquitin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin.
Braun S et al. Cell 2011 Jan 07;144(1):41-54
PMID:39094565 - Mapping the dynamics of epigenetic adaptation in S. pombe during heterochromatin misregulation.
Larkin A et al. Dev Cell 2024 Jul 26;
PMID:37279920 - A dual, catalytic role for the fission yeast Ccr4-Not complex in gene silencing and heterochromatin spreading.
Challal D et al. Genetics 2023 Aug 09;224(4)
PMID:30051891 - Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability.
Iglesias N et al. Nature 2018 Aug;560(7719):504-508
PMID:40093821 - Loss of epe1 + extends chronological lifespan in Schizosaccharomyces pombe .
Basu S et al. MicroPubl Biol 2025;2025
PMID:39945308 - Characterization of the Swi6/HP1 binding motif in its partner protein reveals the basis for the functional divergence of the HP1 family proteins in fission yeast.
Oya T et al. FASEB J 2025 Feb 28;39(4):e70387
PMID:12773576 - A novel jmjC domain protein modulates heterochromatization in fission yeast.
Ayoub N et al. Mol Cell Biol 2003 Jun;23(12):4356-70
PMID:19164572 - Msc1 links dynamic Swi6/HP1 binding to cell fate determination.
Lawrence RJ et al. Proc Natl Acad Sci U S A 2009 Jan 27;106(4):1163-8
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.
Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902
PMID:30573453 - Anti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin.
Bao K et al. Genes Dev 2019 Jan 01;33(1-2):116-126
PMID:25774602 - Rapid epigenetic adaptation to uncontrolled heterochromatin spreading.
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