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protein coding gene - thg1 (SPCC63.07) - tRNA-His 5'-guanylyltransferase Thg1

Gene summary

Standard name
thg1
Systematic ID
SPCC63.07
Product
tRNA-His 5'-guanylyltransferase Thg1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9Y7T3
ORFeome ID
14/14E11
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 848547..849886 forward strand

Annotation

PBO:0002237 - 2.7.7.-

Disease association

MONDO:0032923 - spinocerebellar ataxia, autosomal recessive 28

References:

GO biological process

GO:0099116 - tRNA 5'-end processing

References:

GO:0006400 - tRNA modification

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0000287 - magnesium ion binding

References:

GO:0008193 - tRNA guanylyltransferase activity

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF14413Thg1CThg1_C_domPFAM
PF04446Thg1tRNAHis_GuaTrfase_catPFAM
G3DSA:3.30.70.3000:FF:000003FUNFAM
G3DSA:3.30.70.3000tRNAHis_GuaTrfase_Thg1_sfGENE3D
PTHR12729TRNA(HIS) GUANYLYLTRANSFERASE-RELATEDtRNAHis_GuaTrfase_Thg1PANTHER
PIRSF028980tRNAHis_guanlltrtRNAHis_GuaTrfase_Thg1PIRSF

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
GO_REF:0000002 - Comments
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053