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protein coding gene - myo2 (SPCC645.05c) - myosin II heavy chain

Gene summary

Standard name
myo2
Systematic ID
SPCC645.05c
Product
myosin II heavy chain
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
rng5
UniProt ID
Q9USI6
ORFeome ID
30/30H12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1233231..1238236 reverse strand

Annotation

Comment

PBO:0005426 - functional septation initiation network required

References:

Disease association

MONDO:0007568 - aortic aneurysm, familial thoracic 4

References:

MONDO:0032751 - arthrogryposis, distal, type 2B3

References:

MONDO:0013567 - atrial septal defect 3

References:

MONDO:0011350 - autosomal dominant nonsyndromic hearing loss 17

References:

MONDO:0010915 - autosomal dominant nonsyndromic hearing loss 4A

References:

MONDO:0015285 - Carney complex

References:

MONDO:0012137 - Carney complex - trismus - pseudocamptodactyly syndrome

References:

MONDO:0008409 - congenital myopathy 7A, myosin storage, autosomal dominant

References:

MONDO:0008338 - contractures, pterygia, and spondylocarpotarsal fusion syndrome 1A

References:

MONDO:0020746 - contractures, pterygia, and variable skeletal fusions syndrome 1B

References:

MONDO:0005021 - dilated cardiomyopathy

References:

MONDO:0013198 - dilated cardiomyopathy 1EE

References:

MONDO:0013262 - dilated cardiomyopathy 1S

References:

MONDO:0008675 - Freeman-Sheldon syndrome

References:

MONDO:0005045 - hypertrophic cardiomyopathy

References:

MONDO:0008647 - hypertrophic cardiomyopathy 1

References:

MONDO:0013197 - hypertrophic cardiomyopathy 14

References:

MONDO:0015912 - macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss

References:

MONDO:0025708 - megacystis-microcolon-intestinal hypoperistalsis syndrome 2

References:

MONDO:0008050 - MYH7-related skeletal myopathy

References:

MONDO:0009708 - myopathy, myosin storage, autosomal recessive

References:

MONDO:0011577 - myopathy, proximal, and ophthalmoplegia

References:

MONDO:0013711 - peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome

References:

MONDO:0005201 - restrictive cardiomyopathy

References:

MONDO:0013568 - sick sinus syndrome 3, susceptibility to

References:

MONDO:0008016 - trismus-pseudocamptodactyly syndrome

References:

MONDO:0859157 - visceral myopathy 2

References:

GO biological process

GO:1903475 - mitotic actomyosin contractile ring assembly

References:

GO:1902404 - mitotic actomyosin contractile ring contraction

References:

GO:0000281 - mitotic cytokinesis

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GO cellular component

GO:0032153 - cell division site

References:

GO:0030863 - cortical cytoskeleton

References:

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0031097 - medial cortex

References:

GO:0036391 - medial cortex septin ring

References:

GO:0071341 - medial cortical node

References:

GO:0110085 - mitotic actomyosin contractile ring

References:

GO:0120106 - mitotic actomyosin contractile ring, distal actin filament layer

References:

GO:0120105 - mitotic actomyosin contractile ring, intermediate layer

References:

GO:0120104 - mitotic actomyosin contractile ring, proximal layer

References:

GO:0032982 - myosin filament

References:

GO:0016460 - myosin II complex

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0051015 - actin filament binding

References:

GO:0005524 - ATP binding

References:

GO:0016887 - ATP hydrolysis activity

References:

GO:0030899 - calcium-dependent ATPase activity

References:

GO:0000146 - microfilament motor activity

References:

GO:0005515 - protein binding

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Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00696 - phosphorylated residue

References:

MOD:01148 - ubiquitinylated lysine

References:

Multi-locus phenotype

FYPO:0000161 - abnormal actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0003338 - abnormal actomyosin contractile ring morphology

References:

Genotypes:

FYPO:0002023 - abnormal septum morphology during vegetative growth

References:

Genotypes:

FYPO:0001009 - abolished actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0007966 - abolished nuclear displacement from cell division site after abolished mitotic sister chromatid separation

References:

Genotypes:

FYPO:0002561 - abolished protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0007177 - abolished protein localization to medial cortex during mitotic interphase

References:

Genotypes:

FYPO:0004964 - actin cortical patches present in decreased numbers

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Genotypes:

FYPO:0001008 - actomyosin contractile ring absent

References:

Genotypes:

FYPO:0006940 - asymmetric protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0002050 - branched elongated multinucleate aseptate vegetative cell

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0005902 - decreased rate of actin filament-based movement

References:

Genotypes:

FYPO:0003339 - decreased rate of actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0001365 - decreased rate of actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0006188 - decreased rate of protein exchange in actomyosin contractile ring

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0004653 - delayed onset of actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0000639 - delayed onset of septum assembly

References:

Genotypes:

FYPO:0002021 - dispersed actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0001253 - elongated multinucleate multiseptate vegetative cell, single septa between nuclei

References:

Genotypes:

FYPO:0000223 - elongated multiseptate vegetative cell

References:

Genotypes:

FYPO:0004044 - elongated tetranucleate vegetative cell

References:

Genotypes:

FYPO:0002527 - increased duration of protein localization to cell division site

References:

Genotypes:

FYPO:0009107 - increased nuclear movement velocity during mitotic telophase

References:

Genotypes:

FYPO:0003482 - increased punctate cytoplasmic protein localization

References:

Genotypes:

FYPO:0005901 - increased rate of actin filament-based movement

References:

Genotypes:

FYPO:0006186 - increased rate of actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0000650 - increased septation index

References:

Genotypes:

FYPO:0000252 - increased spontaneous diploidization

References:

Genotypes:

FYPO:0004557 - increased vegetative cell population growth

References:

Genotypes:

FYPO:0000316 - inviable after spore germination

References:

Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

References:

Genotypes:

FYPO:0002515 - inviable after spore germination, without cell division, with branched, elongated germ tube

References:

Genotypes:

FYPO:0002379 - inviable after spore germination, without cell division, with elongated germ tube

References:

Genotypes:

FYPO:0006166 - inviable branched, swollen, elongated, multinucleate vegetative cell

References:

Genotypes:

FYPO:0002059 - inviable cell population

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0004652 - normal actomyosin contractile ring morphology

References:

Genotypes:

FYPO:0001367 - normal cytokinesis

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Genotypes:

FYPO:0005906 - normal onset of actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0002559 - normal protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0005899 - normal rate of actin filament-based movement

References:

Genotypes:

FYPO:0006187 - normal rate of actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0001315 - normal vegetative cell morphology

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0009106 - nucleus mislocalized towards cell equator during mitotic telophase

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Genotypes:

FYPO:0005714 - premature protein localization to nucleolus

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Genotypes:

FYPO:0001214 - sensitive to potassium chloride

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0004043 - tetranucleate vegetative cell

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Genotypes:

FYPO:0006167 - viable branched, swollen, elongated, multinucleate vegetative cell

References:

Genotypes:

FYPO:0001495 - viable elongated multinucleate vegetative cell

References:

Genotypes:

FYPO:0003389 - viable elongated vegetative cell with swollen medial region

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Genotypes:

FYPO:0001491 - viable vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Protein features

PBO:0111829 - IQ domain

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000230 - abnormal actomyosin contractile ring actin filament organization

References:

Genotypes:

FYPO:0000161 - abnormal actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0003338 - abnormal actomyosin contractile ring morphology

References:

Genotypes:

FYPO:0000032 - abnormal cytokinesis during vegetative growth

References:

Genotypes:

FYPO:0003890 - abnormal primary cell septum biogenesis

References:

Genotypes:

FYPO:0002560 - abnormal protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0006327 - abnormal rate of protein exchange in medial cortical node

References:

Genotypes:

FYPO:0002023 - abnormal septum morphology during vegetative growth

References:

Genotypes:

FYPO:0006025 - abolished actin filament binding

References:

Genotypes:

FYPO:0001009 - abolished actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0002998 - abolished actomyosin contractile ring assembly, clumped medial cortical nodes

References:

Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0002561 - abolished protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0003371 - abolished protein localization to actomyosin contractile ring, with protein mislocalized to cytoplasm

References:

Genotypes:

FYPO:0001880 - abolished protein localization to cell division site

References:

Genotypes:

FYPO:0002555 - abolished protein localization to medial cortex during vegetative growth

References:

Genotypes:

FYPO:0003919 - abolished protein localization to medial cortical node

References:

Genotypes:

FYPO:0004735 - abolished protein localization to medial cortical node, with protein mislocalized to cytoplasm

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

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Genotypes:

FYPO:0000949 - aseptate

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Genotypes:

FYPO:0003526 - decreased actin filament-based movement

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0007603 - decreased microfilament motor activity

References:

Genotypes:

FYPO:0002699 - decreased protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0006326 - decreased protein localization to medial cortical node

References:

Genotypes:

FYPO:0001645 - decreased protein-protein interaction

References:

Genotypes:

FYPO:0003339 - decreased rate of actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0001365 - decreased rate of actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0006188 - decreased rate of protein exchange in actomyosin contractile ring

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0004653 - delayed onset of actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0002562 - delayed onset of protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0003946 - delayed onset of protein localization to cell division site

References:

Genotypes:

FYPO:0001253 - elongated multinucleate multiseptate vegetative cell, single septa between nuclei

References:

Genotypes:

FYPO:0000133 - elongated multinucleate vegetative cell

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

References:

Genotypes:

FYPO:0002527 - increased duration of protein localization to cell division site

References:

Genotypes:

FYPO:0002276 - increased protein degradation

References:

Genotypes:

FYPO:0004854 - increased protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0003482 - increased punctate cytoplasmic protein localization

References:

Genotypes:

FYPO:0006186 - increased rate of actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0000650 - increased septation index

References:

Genotypes:

FYPO:0001406 - increased septum thickness

References:

Genotypes:

FYPO:0002170 - inviable after spore germination, multiple cell divisions, branched, elongated cell

References:

Genotypes:

FYPO:0002912 - inviable after spore germination, without cell division, elongated multinucleate cell

References:

Genotypes:

FYPO:0002515 - inviable after spore germination, without cell division, with branched, elongated germ tube

References:

Genotypes:

FYPO:0000315 - inviable after spore germination, without cell division, with elongated, septated germ tube

References:

Genotypes:

FYPO:0003005 - inviable after spore germination, without cell division, with swollen, branched, elongated germ tube

References:

Genotypes:

FYPO:0002462 - inviable branched, elongated vegetative cell

References:

Genotypes:

FYPO:0003413 - inviable branched, elongated, multiseptate vegetative cell

References:

Genotypes:

FYPO:0001493 - inviable elongated multinucleate vegetative cell

References:

Genotypes:

FYPO:0002845 - inviable swollen elongated septated vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0004652 - normal actomyosin contractile ring morphology

References:

Genotypes:

FYPO:0008207 - normal microfilament motor activity

References:

Genotypes:

FYPO:0005905 - normal onset of actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0008090 - normal onset of mitotic anaphase B

References:

Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0002559 - normal protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0002442 - normal protein localization to cell division site

References:

Genotypes:

FYPO:0002558 - normal protein localization to medial cortex during vegetative growth

References:

Genotypes:

FYPO:0002999 - normal protein localization to medial cortical node

References:

Genotypes:

FYPO:0007133 - normal protein localization to medial cortical node during mitotic interphase

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0005899 - normal rate of actin filament-based movement

References:

Genotypes:

FYPO:0004895 - normal rate of actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0002085 - normal vegetative cell growth

References:

Genotypes:

FYPO:0001315 - normal vegetative cell morphology

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0007211 - premature actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0004430 - premature actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0002874 - premature protein localization to medial cortex during vegetative growth

References:

Genotypes:

FYPO:0001098 - sensitive to 4-nitroquinoline N-oxide

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0001495 - viable elongated multinucleate vegetative cell

References:

Genotypes:

FYPO:0002106 - viable stubby vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

FYPO:0002104 - viable vegetative cell with normal cell shape

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00063Myosin_headMyosin_head_motor_dom-likePFAM
PF02736Myosin_NSH3_MyosinPFAM
cd01377MYSc_class_IICDD
PS50096IQPROSITE_PROFILES
PS51844SH3_LIKESH3_MyosinPROSITE_PROFILES
PS51456MYOSIN_MOTORMyosin_head_motor_dom-likePROSITE_PROFILES
SM00242MYSc_2aMyosin_head_motor_dom-likeSMART
PR00193MYOSINHEAVYMyosin_head_motor_dom-likePRINTS
G3DSA:1.10.10.820:FF:000001FUNFAM
G3DSA:1.20.58.530:FF:000001FUNFAM
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
G3DSA:1.10.10.820GENE3D
G3DSA:2.30.30.360Myosin_S1_NGENE3D
G3DSA:1.20.120.720Myosin VI head, motor domain, U50 subdomainGENE3D
G3DSA:1.20.58.530GENE3D
G3DSA:1.20.5.4820GENE3D
G3DSA:3.40.850.10Kinesin motor domainKinesin_motor_dom_sfGENE3D
PTHR13140MYOSINPANTHER
CoilCoilCOILS

Orthologs

References / Literature

PMID:24954052 - Formins determine the functional properties of actin filaments in yeast.
Johnson M et al. Curr Biol 2014 Jul 07;24(13):1525-30
PMID:11112691 - Two type V myosins with non-overlapping functions in the fission yeast Schizosaccharomyces pombe: Myo52 is concerned with growth polarity and cytokinesis, Myo51 is a component of the cytokinetic actin ring.
Win TZ et al. J Cell Sci 2001 Jan;114(Pt 1):69-79
PMID:14602073 - Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis.
Wu JQ et al. Dev Cell 2003 Nov;5(5):723-34
PMID:22573890 - Fission yeast Cyk3p is a transglutaminase-like protein that participates in cytokinesis and cell morphogenesis.
Pollard LW et al. Mol Biol Cell 2012 Jul;23(13):2433-44
PMID:23615450 - Separate roles of IQGAP Rng2p in forming and constricting the Schizosaccharomyces pombe cytokinetic contractile ring.
Tebbs IR et al. Mol Biol Cell 2013 Jun;24(12):1904-17
PMID:15572668 - C-terminal anchoring of mid1p to membranes stabilizes cytokinetic ring position in early mitosis in fission yeast.
Celton-Morizur S et al. Mol Cell Biol 2004 Dec;24(24):10621-35
PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.
Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9
PMID:25977474 - A role for F-BAR protein Rga7p during cytokinesis in S. pombe.
Arasada R et al. J Cell Sci 2015 Jul 01;128(13):2259-68
PMID:41236477 - Actin arginylation alters myosin engagement and F-actin patterning despite structural conservation.
Pinto CS et al. J Cell Biol 2026 Jan 05;225(1)
PMID:11696322 - Roles of the fission yeast formin for3p in cell polarity, actin cable formation and symmetric cell division.
Feierbach B et al. Curr Biol 2001 Oct 30;11(21):1656-65
PMID:19570908 - Regulation of fission yeast myosin-II function and contractile ring dynamics by regulatory light-chain and heavy-chain phosphorylation.
Sladewski TE et al. Mol Biol Cell 2009 Sep;20(17):3941-52
PMID:16224022 - Counting cytokinesis proteins globally and locally in fission yeast.
Wu JQ et al. Science 2005 Oct 14;310(5746):310-4
PMID:15504913 - UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II.
Lord M et al. J Cell Biol 2004 Oct 25;167(2):315-25
PMID:9635188 - Rng2p, a protein required for cytokinesis in fission yeast, is a component of the actomyosin ring and the spindle pole body.
Eng K et al. Curr Biol 1998 May 21;8(11):611-21
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:10852821 - Fission yeast Rng3p: an UCS-domain protein that mediates myosin II assembly during cytokinesis.
Wong KC et al. J Cell Sci 2000 Jul;113 ( Pt 13):2421-32
PMID:35108037 - Fission yeast paxillin contains two Cdc15 binding motifs for robust recruitment to the cytokinetic ring.
Snider CE et al. Mol Biol Cell 2022 Apr 01;33(4):br4
PMID:28808035 - Fission yeast myosin Myo2 is down-regulated in actin affinity by light chain phosphorylation.
Pollard LW et al. Proc Natl Acad Sci U S A 2017 Aug 29;114(35):E7236-E7244
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:20603077 - Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.
Roberts-Galbraith RH et al. Mol Cell 2010 Jul 09;39(1):86-99
PMID:9182664 - Type II myosin heavy chain encoded by the myo2 gene composes the contractile ring during cytokinesis in Schizosaccharomyces pombe.
Kitayama C et al. J Cell Biol 1997 Jun 16;137(6):1309-19
PMID:18951025 - The SIN kinase Sid2 regulates cytoplasmic retention of the S. pombe Cdc14-like phosphatase Clp1.
Chen CT et al. Curr Biol 2008 Oct 28;18(20):1594-9
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:28238661 - Motor Activity Dependent and Independent Functions of Myosin II Contribute to Actomyosin Ring Assembly and Contraction in Schizosaccharomyces pombe.
Palani S et al. Curr Biol 2017 Mar 06;27(5):751-757
PMID:11294907 - Roles of a fimbrin and an alpha-actinin-like protein in fission yeast cell polarization and cytokinesis.
Wu JQ et al. Mol Biol Cell 2001 Apr;12(4):1061-77
PMID:11056543 - Type II myosin regulatory light chain relieves auto-inhibition of myosin-heavy-chain function.
Naqvi NI et al. Nat Cell Biol 2000 Nov;2(11):855-8
PMID:16467379 - Actin-depolymerizing protein Adf1 is required for formation and maintenance of the contractile ring during cytokinesis in fission yeast.
Nakano K et al. Mol Biol Cell 2006 Apr;17(4):1933-45
PMID:22427686 - Characterization of Mid1 domains for targeting and scaffolding in fission yeast cytokinesis.
Lee IJ et al. J Cell Sci 2012 Jun 15;125(Pt 12):2973-85
PMID:30928696 - Distinct Roles of Myosin-II Isoforms in Cytokinesis under Normal and Stressed Conditions.
Okada H et al. iScience 2019 Apr 26;14:69-87
PMID:28914606 - Nanoscale architecture of the Schizosaccharomyces pombe contractile ring.
McDonald NA et al. Elife 2017 Sep 15;6
PMID:22918943 - Anillin-related protein Mid1p coordinates the assembly of the cytokinetic contractile ring in fission yeast.
Saha S et al. Mol Biol Cell 2012 Oct;23(20):3982-92
PMID:12791993 - Equatorial retention of the contractile actin ring by microtubules during cytokinesis.
Pardo M et al. Science 2003 Jun 06;300(5625):1569-74
PMID:24790095 - Characterization of the roles of Blt1p in fission yeast cytokinesis.
Goss JW et al. Mol Biol Cell 2014 Jul 01;25(13):1946-57
PMID:9459302 - Identification of Myo3, a second type-II myosin heavy chain in the fission yeast Schizosaccharomyces pombe.
Motegi F et al. FEBS Lett 1997 Dec 29;420(2-3):161-6
PMID:23770677 - In vitro contraction of cytokinetic ring depends on myosin II but not on actin dynamics.
Mishra M et al. Nat Cell Biol 2013 Jul;15(7):853-9
PMID:30853434 - NDR Kinase Sid2 Drives Anillin-like Mid1 from the Membrane to Promote Cytokinesis and Medial Division Site Placement.
Willet AH et al. Curr Biol 2019 Mar 18;29(6):1055-1063.e2
PMID:18256290 - Schizosaccharomyces pombe Pxl1 is a paxillin homologue that modulates Rho1 activity and participates in cytokinesis.
Pinar M et al. Mol Biol Cell 2008 Apr;19(4):1727-38
PMID:33506191 - Escape from mitotic catastrophe by actin-dependent nuclear displacement in fission yeast.
Yukawa M et al. iScience 2021 Jan 22;24(1):102031
PMID:18378776 - The Clp1/Cdc14 phosphatase contributes to the robustness of cytokinesis by association with anillin-related Mid1.
Clifford DM et al. J Cell Biol 2008 Apr 07;181(1):79-88
PMID:10769212 - Molecular mechanism of myosin-II assembly at the division site in Schizosaccharomyces pombe.
Motegi F et al. J Cell Sci 2000 May;113 ( Pt 10):1813-25
PMID:20807799 - The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast.
Coulton AT et al. J Cell Sci 2010 Oct 01;123(Pt 19):3235-43
PMID:24127216 - The formins Cdc12 and For3 cooperate during contractile ring assembly in cytokinesis.
Coffman VC et al. J Cell Biol 2013 Oct 14;203(1):101-14
PMID:28784611 - Phosphoinositide-mediated ring anchoring resists perpendicular forces to promote medial cytokinesis.
Snider CE et al. J Cell Biol 2017 Oct 02;216(10):3041-3050
PMID:26092938 - An actin-myosin-II interaction is involved in maintaining the contractile ring in fission yeast.
Takaine M et al. J Cell Sci 2015 Aug 01;128(15):2903-18
PMID:26941334 - Unique spatiotemporal activation pattern of Cdc42 by Gef1 and Scd1 promotes different events during cytokinesis.
Wei B et al. Mol Biol Cell 2016 Apr 15;27(8):1235-45
PMID:29343550 - Cdk1-dependent phosphoinhibition of a formin-F-BAR interaction opposes cytokinetic contractile ring formation.
Willet AH et al. Mol Biol Cell 2018 Mar 15;29(6):713-721
PMID:9649519 - Isolation and characterization of new fission yeast cytokinesis mutants.
Balasubramanian MK et al. Genetics 1998 Jul;149(3):1265-75
PMID:15743909 - Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast.
Kovar DR et al. Mol Biol Cell 2005 May;16(5):2313-24
PMID:19805578 - Genome-wide mapping of myosin protein-RNA networks suggests the existence of specialized protein production sites.
Mata J FASEB J 2010 Feb;24(2):479-84
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