PomBase home

protein coding gene - cca2 (SPCC645.10) - ATP 3-'tRNA nucleotidyltransferase Cca2

Gene summary

Standard name
cca2
Systematic ID
SPCC645.10
Product
ATP 3-'tRNA nucleotidyltransferase Cca2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9Y7U9
ORFeome ID
24/24E08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1255204..1257566 forward strand

Annotation

Disease association

MONDO:0014487 - congenital sideroblastic anemia-B-cell immunodeficiency-periodic fever-developmental delay syndrome

References:

MONDO:0014850 - retinitis pigmentosa and erythrocytic microcytosis

References:

GO biological process

GO:1990180 - mitochondrial tRNA 3'-end processing

References:

GO:0001680 - tRNA 3'-terminal CCA addition

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0052929 - ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity

References:

GO:0000049 - tRNA binding

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01743PolyA_polPolA_pol_head_domPfam
PF12627PolyA_pol_RNAbdPolyA_RNA-bdPfam
cd05398NT_ClassII-CCAasePolA_pol_head_domCDD
G3DSA:1.10.3090.10:FF:000013CATH-FunFam
G3DSA:3.30.460.10:FF:000019CATH-FunFam
G3DSA:1.10.3090.10CATH-Gene3D
G3DSA:3.30.460.10NT_sfCATH-Gene3D
SSF81301NT_sfSUPERFAMILY
SSF81891SUPERFAMILY
PTHR13734PANTHER

Orthologs

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:42130072 - Enzyme structure and kinetics produce tRNA and nucleotide specificity of Schizosaccharomyces pombe CC- and A-adding enzymes.
Sikkema AP et al. Nucleic Acids Res 2026 May 05;54(9)
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:30528393 - Schizosaccharomyces pombe contains separate CC- and A-adding tRNA nucleotidyltransferases.
Reid NE et al. Biochem Biophys Res Commun 2019 Jan 15;508(3):785-790
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36