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protein coding gene - trm44 (SPCC663.10) - tRNA(Ser) Um(44) 2'-O-methyltransferase Trm44

Gene summary

Standard name
trm44
Systematic ID
SPCC663.10
Product
tRNA(Ser) Um(44) 2'-O-methyltransferase Trm44
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74516
ORFeome ID
40/40E12
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 1651222..1653177 forward strand

Annotation

GO biological process

GO:0030488 - tRNA methylation

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GO cellular component

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0141101 - tRNA(Ser) (uridine(44)-2'-O-ribose)-methyltransferase activity

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009096 - increased cell population growth on xylose carbon source

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0009071 - sensitive to itraconazole

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF07757AdoMet_MTasetRNA_uracil_MeTrfasePfam
PF28462Bet_v_1_TRM44_NBet_v_1_TRM44_NPfam
SSF53335SAM-dependent_MTases_sfSUPERFAMILY
PTHR21210tRNA_uracil_MeTrfasePANTHER

Orthologs

References / Literature

GO_REF:0000116 - Automatic Gene Ontology annotation based on Rhea mapping.
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12