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protein coding gene - tmp1 (SPCC70.07c) - thymidylate kinase Tmp1

Gene summary

Standard name
tmp1
Systematic ID
SPCC70.07c
Product
thymidylate kinase Tmp1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
tmp
UniProt ID
P36590
ORFeome ID
09/09F11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 2365736..2367472 reverse strand

Annotation

PBO:0005842 - 2.7.4.9

Disease association

MONDO:0859241 - neurodegeneration, childhood-onset, with progressive microcephaly

References:

GO biological process

GO:0006233 - dTDP biosynthetic process

References:

GO:0006235 - dTTP biosynthetic process

References:

GO:0006227 - dUDP biosynthetic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0004798 - dTMP kinase activity

References:

GO:0120136 - dUMP kinase activity

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0003529 - inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02223Thymidylate_kinThymidylate_kin-like_domPfam
cd01672TMPKCDD
PS01331THYMIDYLATE_KINASEThymidylate_kin_CSPROSITE patterns
G3DSA:3.40.50.300:FF:000679CATH-FunFam
G3DSA:3.40.50.300P-loop_NTPaseCATH-Gene3D
SSF52540P-loop_NTPaseSUPERFAMILY
PTHR10344PANTHER
TIGR00041DTMP_kinaseThymidylate_kinaseNCBIFAM
CoilCOILS
MF_00165Thymidylate_kinaseThymidylate_kinaseHAMAP

Orthologs

References / Literature

PMID:9716495 - Isolation and characterization of a processive DNA helicase from the fission yeast Schizosaccharomyces pombe that translocates in a 5'-to-3' direction.
Lee C et al. Biochem J 1998 Sep 01;334 ( Pt 2)(Pt 2):377-86
GO_REF:0000002 - Comments
PMID:9658169 - Identification of novel temperature-sensitive lethal alleles in essential beta-tubulin and nonessential alpha 2-tubulin genes as fission yeast polarity mutants.
Radcliffe P et al. Mol Biol Cell 1998 Jul;9(7):1757-71
PMID:11279180 - A chaperone for ribosome maturation.
Lalev AI et al. J Biol Chem 2001 May 18;276(20):16655-9
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:12360293 - Astral microtubules monitor metaphase spindle alignment in fission yeast.
Oliferenko S et al. Nat Cell Biol 2002 Oct;4(10):816-20
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:25040903 - Eng2 is a component of a dynamic protein complex required for endocytic uptake in fission yeast.
Encinar del Dedo J et al. Traffic 2014 Oct;15(10):1122-42
PMID:1327149 - Functional and structural conservation of Schizosaccharomyces pombe dTMP kinase gene.
Abaigar LT et al. Biochim Biophys Acta 1992 Sep 24;1132(2):222-4
PMID:6308018 - Nucleoside diphosphokinase and cell cycle control in the fission yeast Schizosaccharomyces pombe.
Dickinson JR J Cell Sci 1983 Mar;60:355-65
PMID:1316996 - Cold-sensitive mutants of p34cdc2 that suppress a mitotic catastrophe phenotype in fission yeast.
Ayscough K et al. Mol Gen Genet 1992 Apr;232(3):344-50
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323