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protein coding gene - ecl1 (SPCC70.12c) - TORC1 inhibitor, Ecl1

Gene summary

Standard name
ecl1
Systematic ID
SPCC70.12c
Product
TORC1 inhibitor, Ecl1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPNG2611, SPNCRNA.518
UniProt ID
C6Y4D3
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 2354968..2355787 reverse strand

Annotation

Comment

PBO:0091996 - promoter located -692--679

References:

GO biological process

GO:1904262 - negative regulation of TORC1 signaling

References:

GO:0031137 - regulation of conjugation with cellular fusion

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0004860 - protein kinase inhibitor activity

References:

GO:0030291 - protein serine/threonine kinase inhibitor activity

References:

GO:0008270 - zinc ion binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

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Multi-locus phenotype

FYPO:0008320 - abnormal cell morphology during sulphur deprivation

References:

Genotypes:

FYPO:0007120 - abolished cell cycle arrest in mitotic G1 phase in response to leucine starvation

References:

Genotypes:

FYPO:0008066 - abolished cell cycle arrest in mitotic G1 phase in response to phosphate starvation

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Genotypes:

FYPO:0007500 - abolished macroautophagy during sulfur starvation

References:

Genotypes:

FYPO:0007087 - abolished sporulation during sulfur starvation

References:

Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0008064 - decreased mating efficiency during phosphate starvation

References:

Genotypes:

FYPO:0006331 - decreased mating efficiency during stationary phase

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Genotypes:

FYPO:0001838 - decreased protein phosphorylation during vegetative growth

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Genotypes:

FYPO:0007084 - decreased RNA level during cellular response to sulfur starvation

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Genotypes:

FYPO:0006334 - decreased RNA level during cellular response to zinc ion starvation

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Genotypes:

FYPO:0002944 - decreased RNA level during G0

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Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

References:

Genotypes:

FYPO:0000584 - decreased sporulation frequency

References:

Genotypes:

FYPO:0008065 - decreased sporulation frequency during phosphate starvation

References:

Genotypes:

FYPO:0000712 - delayed onset of cell cycle arrest in mitotic G1 phase in response to nitrogen starvation

References:

Genotypes:

FYPO:0007086 - elongated vegetative cell during sulfur starvation

References:

Genotypes:

FYPO:0007093 - increased level of ribosomal protein gene mRNA during vegetative growth

References:

Genotypes:

FYPO:0008427 - increased protein level during cellular response to sulfur starvation

References:

Genotypes:

FYPO:0008428 - increased protein phosphorylation during sulfur starvation

References:

Genotypes:

FYPO:0007085 - increased RNA level during cellular response to sulfur starvation

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0007119 - loss of viability upon amino acid starvation

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Genotypes:

FYPO:0007792 - loss of viability upon magnesium starvation

References:

Genotypes:

FYPO:0001178 - loss of viability upon nitrogen starvation

References:

Genotypes:

FYPO:0007088 - loss of viability upon sulfur starvation

References:

Genotypes:

FYPO:0007089 - normal cell cycle arrest at mitotic G2/M phase transition during sulfur starvation

References:

Genotypes:

FYPO:0002048 - normal cell morphology during nitrogen starvation

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Genotypes:

FYPO:0001147 - normal mating efficiency

References:

Genotypes:

FYPO:0004993 - normal spore germination frequency

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Genotypes:

FYPO:0002052 - normal sporulation frequency

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Genotypes:

FYPO:0005549 - normal viability upon nitrogen starvation

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Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0000271 - sensitive to salt stress

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Genotypes:

FYPO:0000112 - sensitive to sorbitol

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Genotypes:

FYPO:0000280 - sterile

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

Qualitative gene expression

PomGeneEx:0000023 - protein level constant

References:

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000021 - protein present

References:

PomGeneEx:0000011 - RNA level increased

References:

PomGeneEx:0000013 - RNA level unchanged

References:

PomGeneEx:0000014 - RNA present

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0005097 - abnormal cell cycle arrest in mitotic G1 phase

References:

Genotypes:

FYPO:0002780 - decreased cellular reactive oxygen species level during vegetative growth

References:

Genotypes:

FYPO:0002143 - decreased cellular reactive oxygen species level in stationary phase

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0006331 - decreased mating efficiency during stationary phase

References:

Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

References:

Genotypes:

FYPO:0004085 - decreased vegetative cell growth

References:

Genotypes:

FYPO:0006333 - decreased zinc ion binding

References:

Genotypes:

FYPO:0007086 - elongated vegetative cell during sulfur starvation

References:

Genotypes:

FYPO:0002173 - increased level of meiotic gene mRNA during vegetative growth

References:

Genotypes:

FYPO:0002172 - increased level of nitrogen starvation gene mRNA during vegetative growth

References:

Genotypes:

FYPO:0002664 - increased level of stress responsive gene mRNA during vegetative growth

References:

Genotypes:

FYPO:0002989 - increased level of transmembrane transport gene mRNA during vegetative growth

References:

Genotypes:

FYPO:0001043 - increased mating efficiency

References:

Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

References:

Genotypes:

FYPO:0000588 - increased sporulation frequency

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

References:

Genotypes:

FYPO:0002141 - normal cell population growth at low temperature

References:

Genotypes:

FYPO:0001037 - normal growth during cellular response to salt stress

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0000961 - normal growth on sorbitol

References:

Genotypes:

FYPO:0001147 - normal mating efficiency

References:

Genotypes:

FYPO:0000644 - normal protein localization during vegetative growth

References:

Genotypes:

FYPO:0000776 - normal protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0001310 - normal viability in stationary phase

References:

Genotypes:

FYPO:0004168 - normal viability in stationary phase during glucose starvation

References:

Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0000280 - sterile

References:

Genotypes:

Taxonomic conservation

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

Warnings

PBO:0000082 - new gene

References:

PBO:0000406 - previously annotated as ncRNA

Protein features

IDNameInterPro nameDB name
PF12855Ecl1Ecl1/2/3PFAM

Orthologs

References / Literature

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:28388826 - Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome.
Ohtsuka H et al. Mol Microbiol 2017 Jul;105(1):84-97
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:39910760 - Novel TORC1 inhibitor Ecl1 is regulated by phosphorylation in fission yeast.
Ohtsuka H et al. Aging Cell 2025 Feb 05;:e14450
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39105351 - A novel transcription factor Sdr1 involving sulfur depletion response in fission yeast.
Ohtsuka H et al. Genes Cells 2024 Aug;29(8):667-680
PMID:31456006 - Leucine depletion extends the lifespans of leucine-auxotrophic fission yeast by inducing Ecl1 family genes via the transcription factor Fil1.
Ohtsuka H et al. Mol Genet Genomics 2019 Dec;294(6):1499-1509
PMID:19352039 - Identification of Ecl family genes that extend chronological lifespan in fission yeast.
Ohtsuka H et al. Biosci Biotechnol Biochem 2009 Apr 23;73(4):885-9
PMID:21072667 - hsf1 (+) extends chronological lifespan through Ecl1 family genes in fission yeast.
Ohtsuka H et al. Mol Genet Genomics 2011 Jan;285(1):67-77
PMID:40395999 - Cdc13 (cyclin B) is degraded by autophagy under sulfur depletion in fission yeast.
Ohtsuka H et al. Autophagy Rep 2022;1(1):51-64
PMID:18422613 - A novel gene, ecl1(+), extends the chronological lifespan in fission yeast.
Ohtsuka H et al. FEMS Yeast Res 2008 Jun;8(4):520-30
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:33064910 - Sulfur depletion induces autophagy through Ecl1 family genes in fission yeast.
Shimasaki T et al. Genes Cells 2020 Dec;25(12):825-830
PMID:28934413 - Factors extending the chronological lifespan of yeast: Ecl1 family genes.
Ohtsuka H et al. FEMS Yeast Res 2017 Nov 01;17(7)
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:24696293 - Ecl1 is activated by the transcription factor Atf1 in response to H2O2 stress in Schizosaccharomyces pombe.
Shimasaki T et al. Mol Genet Genomics 2014 Aug;289(4):685-93
PMID:36882296 - Duf89 abets lncRNA control of fission yeast phosphate homeostasis via its antagonism of precocious lncRNA transcription termination.
Sanchez AM et al. RNA 2023 Jun;29(6):808-825
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:21307597 - Ecl1, a regulator of the chronological lifespan of Schizosaccharomyces pombe, is induced upon nitrogen starvation.
Miwa Y et al. Biosci Biotechnol Biochem 2011;75(2):279-83
PMID:28160081 - Ecl1 is a zinc-binding protein involved in the zinc-limitation-dependent extension of chronological life span in fission yeast.
Shimasaki T et al. Mol Genet Genomics 2017 Apr;292(2):475-481
PMID:22212525 - Chronological lifespan extension by Ecl1 family proteins depends on Prr1 response regulator in fission yeast.
Ohtsuka H et al. Genes Cells 2012 Jan;17(1):39-52
PMID:36779416 - The ecl family gene ecl3+ is induced by phosphate starvation and contributes to sexual differentiation in fission yeast.
Ohtsuka H et al. J Cell Sci 2023 Mar 15;136(6)
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:25204792 - Sexual development of Schizosaccharomyces pombe is induced by zinc or iron limitation through Ecl1 family genes.
Ohtsuka H et al. Mol Genet Genomics 2015 Feb;290(1):173-85
PMID:33970532 - Magnesium depletion extends fission yeast lifespan via general amino acid control activation.
Ohtsuka H et al. Microbiologyopen 2021 Mar;10(2):e1176
PMID:18488015 - Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution.
Wilhelm BT et al. Nature 2008 Jun 26;453(7199):1239-43