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protein coding gene - msf1 (SPCC736.03c) - mitochondrial phenylalanyl-tRNA synthetase Msf1

Gene summary

Standard name
msf1
Systematic ID
SPCC736.03c
Product
mitochondrial phenylalanyl-tRNA synthetase Msf1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74952
ORFeome ID
22/22D04
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 314077..315844 reverse strand

Annotation

PBO:0001916 - 6.1.1.20

Disease association

MONDO:0013986 - combined oxidative phosphorylation defect type 14

References:

MONDO:0014882 - hereditary spastic paraplegia 77

References:

GO biological process

GO:0032543 - mitochondrial translation

References:

GO:0006418 - tRNA aminoacylation for protein translation

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0004826 - phenylalanine-tRNA ligase activity

References:

GO:0000049 - tRNA binding

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01409tRNA-synt_2dPhenylalanyl-tRNA_SynthasePfam
PF03147FDX-ACBFdx_antiC-bdPfam
cd00496PheRS_alpha_coreCDD
PS50862AA_TRNA_LIGASE_IIaa-tRNA-synth_IIPROSITE profiles
PS51447FDX_ACBFdx_antiC-bdPROSITE profiles
SM00896FDX-ACBFdx_antiC-bdSMART
G3DSA:3.30.70.380:FF:000003CATH-FunFam
G3DSA:3.30.930.10:FF:000053CATH-FunFam
G3DSA:3.30.70.380Fdx_antiC-bd_sfCATH-Gene3D
G3DSA:3.30.930.10aa-tRNA-synth_II/BPL/LPLCATH-Gene3D
SSF54991Fdx_antiC-bd_sfSUPERFAMILY
SSF55681aa-tRNA-synth_II/BPL/LPLSUPERFAMILY
PTHR11538PANTHER
TIGR00469pheS_mitoPhe-tRNA-synth_IIc_mitoNCBIFAM

Orthologs

References / Literature

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000002 - Comments
GO_REF:0000051 - S. pombe keyword mapping
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643