protein coding gene - tfx1 (SPCC736.09c) - TRAX

Gene summary

Standard name

tfx1

Systematic ID

SPCC736.09c

Product

TRAX

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O74955

ORFeome ID

08/08B07

Characterisation status

biological role inferred

Feature type

mRNA gene

Genomic location

chromosome III: 329570..330603 reverse strand

Annotation

Protein features

Orthologs

• TSNAX (HGNC:12380) Homo sapiens
• tfx1 (SJAG_04091) Schizosaccharomyces japonicus

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:16043634 - Cloning and characterization of the Schizosaccharomyces pombe homologs of the human protein Translin and the Translin-associated protein TRAX.

Laufman O et al. Nucleic Acids Res 2005;33(13):4128-39

PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:22252817 - A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.

Fang Y et al. Antimicrob Agents Chemother 2012 Apr;56(4):1949-59

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:36098897 - Biochemical characterization of clinically relevant mutations of human Translin.

Pillai V et al. Mol Cell Biochem 2023 Apr;478(4):821-834

PMID:24382491 - Identification of proteins that form specific complexes with the highly conserved protein Translin in Schizosaccharomyces pombe.

Eliahoo E et al. Biochim Biophys Acta 2014 Apr;1844(4):767-77

PMID:20081200 - Mapping of interaction sites of the Schizosaccharomyces pombe protein Translin with nucleic acids and proteins: a combined molecular genetics and bioinformatics study.

Eliahoo E et al. Nucleic Acids Res 2010 May;38(9):2975-89

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:12618370 - Schizosaccharomyces pombe essential genes: a pilot study.

Decottignies A et al. Genome Res 2003 Mar;13(3):399-406

GO_REF:0000002 - Comments

PMID:18062930 - Functional characterisation of the Schizosaccharomyces pombe homologue of the leukaemia-associated translocation breakpoint binding protein translin and its binding partner, TRAX.

Jaendling A et al. Biochim Biophys Acta 2008 Feb;1783(2):203-13

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:27183912 - Translin and Trax differentially regulate telomere-associated transcript homeostasis.

Gomez-Escobar N et al. Oncotarget 2016 Jun 07;7(23):33809-20

PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.

Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480