protein coding gene - ago1 (SPCC736.11) - argonaute

Gene summary

Standard name

ago1

Systematic ID

SPCC736.11

Product

argonaute

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

csp9

UniProt ID

O74957

ORFeome ID

29/29F08

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 334079..337070 forward strand

Annotation

Protein features

Orthologs

• PIWIL2 (HGNC:17644) Homo sapiens
• PIWIL3 (HGNC:18443) Homo sapiens
• PIWIL4 (HGNC:18444) Homo sapiens
• PIWIL1 (HGNC:9007) Homo sapiens
• ago1 (SJAG_02621) Schizosaccharomyces japonicus

References / Literature

PMID:26631744 - Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing.

Chalamcharla VR et al. Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15548-55

PMID:18345014 - Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin.

Zhang K et al. Nat Struct Mol Biol 2008 Apr;15(4):381-8

PMID:16931764 - Argonaute slicing is required for heterochromatic silencing and spreading.

Irvine DV et al. Science 2006 Aug 25;313(5790):1134-7

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:26518661 - The Paf1 complex factors Leo1 and Paf1 promote local histone turnover to modulate chromatin states in fission yeast.

Sadeghi L et al. EMBO Rep 2015 Dec;16(12):1673-87

PMID:17289569 - SHREC, an effector complex for heterochromatic transcriptional silencing.

Sugiyama T et al. Cell 2007 Feb 09;128(3):491-504

PMID:28784663 - The 19S proteasome is directly involved in the regulation of heterochromatin spreading in fission yeast.

Seo HD et al. J Biol Chem 2017 Oct 13;292(41):17144-17155

PMID:24493644 - lncRNA recruits RNAi and the exosome to dynamically regulate pho1 expression in response to phosphate levels in fission yeast.

Shah S et al. Genes Dev 2014 Feb 01;28(3):231-44

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:19693008 - Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAs.

Zofall M et al. Nature 2009 Sep 17;461(7262):419-22

PMID:24095277 - Argonaute and Triman generate dicer-independent priRNAs and mature siRNAs to initiate heterochromatin formation.

Marasovic M et al. Mol Cell 2013 Oct 24;52(2):173-83

PMID:22768388 - Translational control of cell division by Elongator.

Bauer F et al. Cell Rep 2012 May 31;1(5):424-33

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:30652128 - Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription.

Okita AK et al. Commun Biol 2019;2:17

PMID:28541282 - Tailing and degradation of Argonaute-bound small RNAs protect the genome from uncontrolled RNAi.

Pisacane P et al. Nat Commun 2017 May 25;8:15332

PMID:27738016 - RNA interference is essential for cellular quiescence.

Roche B et al. Science 2016 Nov 11;354(6313)

PMID:17310250 - Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast.

Buker SM et al. Nat Struct Mol Biol 2007 Mar;14(3):200-7

PMID:12193640 - Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi.

Volpe TA et al. Science 2002 Sep 13;297(5588):1833-7

PMID:28636937 - The Conserved RNA Binding Cyclophilin, Rct1, Regulates Small RNA Biogenesis and Splicing Independent of Heterochromatin Assembly.

Chang AY et al. Cell Rep 2017 Jun 20;19(12):2477-2489

PMID:22989756 - RNA interference regulates the cell cycle checkpoint through the RNA export factor, Ptr1, in fission yeast.

Iida T et al. Biochem Biophys Res Commun 2012 Oct 12;427(1):143-7

PMID:17043360 - Interactions between the RNA interference effector protein Ago1 and 14-3-3 proteins: consequences for cell cycle progression.

Stoica C et al. J Biol Chem 2006 Dec 08;281(49):37646-51

PMID:20211136 - Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity.

Bayne EH et al. Cell 2010 Mar 05;140(5):666-77

PMID:20404084 - Transcriptional activation of the general amino acid permease gene per1 by the histone deacetylase Clr6 Is regulated by Oca2 kinase.

Kaufmann I et al. Mol Cell Biol 2010 Jul;30(13):3396-410

PMID:36617881 - Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an antisilencing factor, Epe1, in fission yeast.

Asanuma T et al. Genes Dev 2022 Nov;36(21-24):1145-1159

PMID:39094570 - A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance.

Yu J et al. Cell 2024 Sep 05;187(18):5010-5028.e24

PMID:16762840 - Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeats.

Zofall M et al. Mol Cell 2006 Jun 09;22(5):681-92

PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.

Vega M et al. BMC Biol 2022 Jul 12;20(1):160

PMID:20062003 - Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast.

Simmer F et al. EMBO Rep 2010 Feb;11(2):112-8

PMID:23613586 - Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification.

He C et al. Proc Natl Acad Sci U S A 2013 May 21;110(21):E1879-88

PMID:26443059 - Sgf73, a subunit of SAGA complex, is required for the assembly of RITS complex in fission yeast.

Deng X et al. Sci Rep 2015 Oct 07;5:14707

PMID:15615848 - RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production.

Sugiyama T et al. Proc Natl Acad Sci U S A 2005 Jan 04;102(1):152-7

PMID:29136238 - Regulation of transcriptional silencing and chromodomain protein localization at centromeric heterochromatin by histone H3 tyrosine 41 phosphorylation in fission yeast.

Ren B et al. Nucleic Acids Res 2018 Jan 09;46(1):189-202

PMID:30051891 - Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability.

Iglesias N et al. Nature 2018 Aug;560(7719):504-508

PMID:27889481 - Mitotic Nuclear Envelope Breakdown and Spindle Nucleation Are Controlled by Interphase Contacts between Centromeres and the Nuclear Envelope.

Fernández-Álvarez A et al. Dev Cell 2016 Dec 05;39(5):544-559

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:40063661 - Fission yeast Caprin protein is required for efficient heterochromatin establishment.

Zhang H et al. PLoS Genet 2025 Mar 10;21(3):e1011620

PMID:28404620 - Accumulation of RNA on chromatin disrupts heterochromatic silencing.

Brönner C et al. Genome Res 2017 Jul;27(7):1174-1183

PMID:20705239 - The methyltransferase activity of Clr4Suv39h triggers RNAi independently of histone H3K9 methylation.

Gerace EL et al. Mol Cell 2010 Aug 13;39(3):360-72

PMID:15372076 - A chromodomain protein, Chp1, is required for the establishment of heterochromatin in fission yeast.

Sadaie M et al. EMBO J 2004 Oct 01;23(19):3825-35

PMID:19164572 - Msc1 links dynamic Swi6/HP1 binding to cell fate determination.

Lawrence RJ et al. Proc Natl Acad Sci U S A 2009 Jan 27;106(4):1163-8

PMID:35171902 - The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly.

Bao K et al. PLoS Genet 2022 Feb;18(2):e1010049

PMID:16797182 - Conserved ribonuclease, Eri1, negatively regulates heterochromatin assembly in fission yeast.

Iida T et al. Curr Biol 2006 Jul 25;16(14):1459-64

PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.

Malecki M et al. Genome Biol 2016 Nov 25;17(1):240

PMID:29654060 - RNAi drives nonreciprocal translocations at eroding chromosome ends to establish telomere-free linear chromosomes.

Begnis M et al. Genes Dev 2018 Apr 01;32(7-8):537-554

PMID:19883398 - The Kinesin motor protein Cut7 regulates biogenesis and function of Ago1-complexes.

Stoica C et al. Traffic 2010 Jan;11(1):25-36

PMID:23771057 - Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast.

Alper BJ et al. EMBO J 2013 Aug 28;32(17):2321-35

PMID:28228545 - Ablation of RNA interference and retrotransposons accompany acquisition and evolution of transposases to heterochromatin protein CENPB.

Upadhyay U et al. Mol Biol Cell 2017 Apr 15;28(8):1132-1146

PMID:20178743 - Dicer-independent primal RNAs trigger RNAi and heterochromatin formation.

Halic M et al. Cell 2010 Feb 19;140(4):504-16

PMID:39747188 - PhpC NF-Y transcription factor infiltrates heterochromatin to generate cryptic intron-containing transcripts crucial for small RNA production.

Srivastav MK et al. Nat Commun 2025 Jan 02;16(1):268

PMID:15475954 - RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing.

Noma K et al. Nat Genet 2004 Nov;36(11):1174-80

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:15218150 - RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins.

Jia S et al. Science 2004 Jun 25;304(5679):1971-6

PMID:28231281 - The intron in centromeric noncoding RNA facilitates RNAi-mediated formation of heterochromatin.

Mutazono M et al. PLoS Genet 2017 Feb;13(2):e1006606

PMID:14704433 - RNAi-mediated targeting of heterochromatin by the RITS complex.

Verdel A et al. Science 2004 Jan 30;303(5658):672-6

PMID:14699070 - ago1 and dcr1, two core components of the RNA interference pathway, functionally diverge from rdp1 in regulating cell cycle events in Schizosaccharomyces pombe.

Carmichael JB et al. Mol Biol Cell 2004 Mar;15(3):1425-35

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:29866182 - RNAi-dependent heterochromatin assembly in fission yeast Schizosaccharomyces pombe requires heat-shock molecular chaperones Hsp90 and Mas5.

Okazaki K et al. Epigenetics Chromatin 2018 Jun 04;11(1):26

PMID:28682306 - Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription.

Jih G et al. Nature 2017 Jul 27;547(7664):463-467

PMID:17512405 - RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing.

Bühler M et al. Cell 2007 May 18;129(4):707-21

PMID:39094565 - Mapping the dynamics of epigenetic adaptation in S. pombe during heterochromatin misregulation.

Larkin A et al. Dev Cell 2024 Jul 26;

PMID:22474355 - Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly.

Hayashi A et al. Proc Natl Acad Sci U S A 2012 Apr 17;109(16):6159-64

PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.

Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15

PMID:22002604 - RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II.

Zaratiegui M et al. Nature 2011 Oct 16;479(7371):135-8

PMID:31278118 - Cohesin Impedes Heterochromatin Assembly in Fission Yeast Cells Lacking Pds5.

Folco HD et al. Genetics 2019 Sep;213(1):127-141

PMID:25428589 - Long non-coding RNA-mediated transcriptional interference of a permease gene confers drug tolerance in fission yeast.

Ard R et al. Nat Commun 2014 Nov 27;5:5576

PMID:25831549 - Epigenetics. Epigenetic inheritance uncoupled from sequence-specific recruitment.

Ragunathan K et al. Science 2015 Apr 03;348(6230):1258699

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:25730778 - Small-RNA loading licenses Argonaute for assembly into a transcriptional silencing complex.

Holoch D et al. Nat Struct Mol Biol 2015 Apr;22(4):328-35

PMID:29237752 - Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi.

Kajitani T et al. Proc Natl Acad Sci U S A 2017 Dec 26;114(52):E11208-E11217

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:15743828 - RNA interference (RNAi)-dependent and RNAi-independent association of the Chp1 chromodomain protein with distinct heterochromatic loci in fission yeast.

Petrie VJ et al. Mol Cell Biol 2005 Mar;25(6):2331-46

PMID:24240238 - Elimination of shelterin components bypasses RNAi for pericentric heterochromatin assembly.

Tadeo X et al. Genes Dev 2013 Nov 15;27(22):2489-99

PMID:18948543 - Splicing factors facilitate RNAi-directed silencing in fission yeast.

Bayne EH et al. Science 2008 Oct 24;322(5901):602-6

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:40132111 - A fission yeast CENP-B homologue Abp1 prevents RNAi-mediated heterochromatin formation at ribosomal DNA repeats.

Tsunemine S et al. Genetics 2025 Mar 25;

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:32415063 - Conserved protein Pir2 ARS2 mediates gene repression through cryptic introns in lncRNAs.

Thillainadesan G et al. Nat Commun 2020 May 15;11(1):2412

PMID:34010645 - The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin.

Shan CM et al. Cell Rep 2021 May 18;35(7):109137

PMID:39358553 - Ageing-associated long non-coding RNA extends lifespan and reduces translation in non-dividing cells.

Anver S et al. EMBO Rep 2024 Oct 02;

PMID:22431512 - RNAi keeps Atf1-bound stress response genes in check at nuclear pores.

Woolcock KJ et al. Genes Dev 2012 Apr 01;26(7):683-92

PMID:27183912 - Translin and Trax differentially regulate telomere-associated transcript homeostasis.

Gomez-Escobar N et al. Oncotarget 2016 Jun 07;7(23):33809-20

PMID:31206516 - Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1.

Sorida M et al. PLoS Genet 2019 Jun;15(6):e1008129

PMID:37913773 - TOR inactivation triggers heterochromatin formation in rDNA during glucose starvation.

Hirai H et al. Cell Rep 2023 Nov 28;42(11):113320

PMID:27538348 - Set3 contributes to heterochromatin integrity by promoting transcription of subunits of Clr4-Rik1-Cul4 histone methyltransferase complex in fission yeast.

Yu Y et al. Sci Rep 2016 Aug 19;6:31752

PMID:22144463 - RNA elimination machinery targeting meiotic mRNAs promotes facultative heterochromatin formation.

Zofall M et al. Science 2012 Jan 06;335(6064):96-100

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:23151475 - RNAi triggered by specialized machinery silences developmental genes and retrotransposons.

Yamanaka S et al. Nature 2013 Jan 24;493(7433):557-60

PMID:15607976 - Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs.

Motamedi MR et al. Cell 2004 Dec 17;119(6):789-802

PMID:41316862 - Deletion of Elongator Protein 1 (Elp1) relieves heterochromatin defects in a Pol II mutant of Schizosaccharomyces pombe.

Nirmal MB et al. Genetics 2025 Nov 29;

PMID:18957202 - Lid2 is required for coordinating H3K4 and H3K9 methylation of heterochromatin and euchromatin.

Li F et al. Cell 2008 Oct 17;135(2):272-83

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:32101745 - Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.

Lee SY et al. Cell Rep 2020 Feb 25;30(8):2686-2698.e8

PMID:23604080 - HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin.

Aygün O et al. Nat Struct Mol Biol 2013 May;20(5):547-54

PMID:22268381 - The karyopherin Sal3 is required for nuclear import of the core RNA interference pathway protein Rdp1.

Park J et al. Traffic 2012 Apr;13(4):520-31

PMID:21289066 - Elimination of a specific histone H3K14 acetyltransferase complex bypasses the RNAi pathway to regulate pericentric heterochromatin functions.

Reddy BD et al. Genes Dev 2011 Feb 01;25(3):214-9

PMID:15632061 - Global effects on gene expression in fission yeast by silencing and RNA interference machineries.

Hansen KR et al. Mol Cell Biol 2005 Jan;25(2):590-601

PMID:38285941 - Specialized replication of heterochromatin domains ensures self-templated chromatin assembly and epigenetic inheritance.

Nathanailidou P et al. Proc Natl Acad Sci U S A 2024 Feb 06;121(6):e2315596121

PMID:31269446 - CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing.

Vo TV et al. Cell Rep 2019 Jul 02;28(1):267-281.e5

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:24766403 - Mudi, a web tool for identifying mutations by bioinformatics analysis of whole-genome sequence.

Iida N et al. Genes Cells 2014 Jun;19(6):517-27

PMID:24874881 - The proper splicing of RNAi factors is critical for pericentric heterochromatin assembly in fission yeast.

Kallgren SP et al. PLoS Genet 2014;10(5):e1004334

PMID:16734665 - RNA interference effector proteins localize to mobile cytoplasmic puncta in Schizosaccharomyces pombe.

Carmichael JB et al. Traffic 2006 Aug;7(8):1032-44

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:22895252 - A novel RNAi protein, Dsh1, assembles RNAi machinery on chromatin to amplify heterochromatic siRNA.

Kawakami K et al. Genes Dev 2012 Aug 15;26(16):1811-24

PMID:28648780 - The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

Flury V et al. Mol Cell 2017 Jul 20;67(2):294-307.e9

PMID:33378674 - The INO80 Complex Regulates Epigenetic Inheritance of Heterochromatin.

Shan CM et al. Cell Rep 2020 Dec 29;33(13):108561

PMID:37445861 - Resistance to Chemotherapeutic 5-Fluorouracil Conferred by Modulation of Heterochromatic Integrity through Ino80 Function in Fission Yeast.

Lim KK et al. Int J Mol Sci 2023 Jun 26;24(13)

PMID:19362535 - High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin.

Schalch T et al. Mol Cell 2009 Apr 10;34(1):36-46

PMID:20018856 - Involvement of the spliceosomal U4 small nuclear RNA in heterochromatic gene silencing at fission yeast centromeres.

Chinen M et al. J Biol Chem 2010 Feb 19;285(8):5630-8

PMID:29214404 - The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast.

Seo HD et al. Curr Genet 2018 Jun;64(3):741-752

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:17531816 - Functional separation of the requirements for establishment and maintenance of centromeric heterochromatin.

Partridge JF et al. Mol Cell 2007 May 25;26(4):593-602

PMID:25417108 - Dicer promotes transcription termination at sites of replication stress to maintain genome stability.

Castel SE et al. Cell 2014 Oct 23;159(3):572-83

PMID:30810475 - Early splicing functions of fission yeast Prp16 and its unexpected requirement for gene Silencing is governed by intronic features.

Vijayakumari D et al. RNA Biol 2019 Jun;16(6):754-769

PMID:17891150 - A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain.

Till S et al. Nat Struct Mol Biol 2007 Oct;14(10):897-903

PMID:29914874 - Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast.

Atkinson SR et al. RNA 2018 Sep;24(9):1195-1213

PMID:32295063 - The Catalytic-Dependent and -Independent Roles of Lsd1 and Lsd2 Lysine Demethylases in Heterochromatin Formation in Schizosaccharomyces pombe .

Marayati BF et al. Cells 2020 Apr 13;9(4)

PMID:26889830 - A Novel Epigenetic Silencing Pathway Involving the Highly Conserved 5'-3' Exoribonuclease Dhp1/Rat1/Xrn2 in Schizosaccharomyces pombe.

Tucker JF et al. PLoS Genet 2016 Feb;12(2):e1005873

PMID:21151114 - Dicer associates with chromatin to repress genome activity in Schizosaccharomyces pombe.

Woolcock KJ et al. Nat Struct Mol Biol 2011 Jan;18(1):94-9

PMID:21892171 - Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin.

Reyes-Turcu FE et al. Nat Struct Mol Biol 2011 Sep 04;18(10):1132-8

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:32499408 - The molecular chaperone Hsp90 regulates heterochromatin assembly through stabilizing multiple complexes in fission yeast.

Sun L et al. J Cell Sci 2020 Jul 07;133(13)

PMID:25245948 - Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length.

Wang J et al. Nucleic Acids Res 2014 Oct;42(18):11419-32