protein coding gene - dis1 (SPCC736.14) - TOG/XMAP215 microtubule plus end tracking polymerase Dis1

Gene summary

Standard name

dis1

Systematic ID

SPCC736.14

Product

TOG/XMAP215 microtubule plus end tracking polymerase Dis1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q09933

ORFeome ID

29/29G02

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 342865..346242 forward strand

Annotation

Protein features

Orthologs

• CKAP5 (HGNC:28959) Homo sapiens
• dis1 (SJAG_02624) Schizosaccharomyces japonicus
• STU2 (YLR045C) Saccharomyces cerevisiae

References / Literature

PMID:23166349 - Csi1 links centromeres to the nuclear envelope for centromere clustering.

Hou H et al. J Cell Biol 2012 Nov 26;199(5):735-44

PMID:16688222 - Histone H2B mutations in inner region affect ubiquitination, centromere function, silencing and chromosome segregation.

Maruyama T et al. EMBO J 2006 Jun 07;25(11):2420-31

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:26510788 - Escape from Mitotic Arrest: An Unexpected Connection Between Microtubule Dynamics and Epigenetic Regulation of Centromeric Chromatin in Schizosaccharomyces pombe.

George AA et al. Genetics 2015 Dec;201(4):1467-78

PMID:11432827 - Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint.

Garcia MA et al. EMBO J 2001 Jul 02;20(13):3389-401

PMID:12390246 - Cut1/separase C-terminus affects spindle pole body positioning in interphase of fission yeast: pointed nuclear formation.

Nakamura T et al. Genes Cells 2002 Nov;7(11):1113-24

PMID:22521786 - Phosphodependent recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 kinase maintains the spindle checkpoint.

Shepperd LA et al. Curr Biol 2012 May 22;22(10):891-9

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:28502666 - Purification and characterisation of the fission yeast Ndc80 complex.

Matsuo Y et al. Protein Expr Purif 2017 Jul;135:61-69

PMID:36435910 - Fission yeast Dis1 is an unconventional TOG/XMAP215 that induces microtubule catastrophe to drive chromosome pulling.

Murase Y et al. Commun Biol 2022 Nov 26;5(1):1298

PMID:26124291 - A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit.

Laporte D et al. J Cell Biol 2015 Jul 06;210(1):99-113

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:8485317 - A mitotic role for a novel fission yeast protein kinase dsk1 with cell cycle stage dependent phosphorylation and localization.

Takeuchi M et al. Mol Biol Cell 1993 Mar;4(3):247-60

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:25764183 - Condensin HEAT subunits required for DNA repair, kinetochore/centromere function and ploidy maintenance in fission yeast.

Xu X et al. PLoS One 2015;10(3):e0119347

PMID:12426374 - Spindle-kinetochore attachment requires the combined action of Kin I-like Klp5/6 and Alp14/Dis1-MAPs in fission yeast.

Garcia MA et al. EMBO J 2002 Nov 15;21(22):6015-24

PMID:12376568 - An evolutionarily conserved fission yeast protein, Ned1, implicated in normal nuclear morphology and chromosome stability, interacts with Dis3, Pim1/RCC1 and an essential nucleoporin.

Tange Y et al. J Cell Sci 2002 Nov 15;115(Pt 22):4375-85

PMID:23427262 - The internal loop of fission yeast Ndc80 binds Alp7/TACC-Alp14/TOG and ensures proper chromosome attachment.

Tang NH et al. Mol Biol Cell 2013 Apr;24(8):1122-33

PMID:14742702 - Interdependency of fission yeast Alp14/TOG and coiled coil protein Alp7 in microtubule localization and bipolar spindle formation.

Sato M et al. Mol Biol Cell 2004 Apr;15(4):1609-22

PMID:3409871 - Cold-sensitive and caffeine-supersensitive mutants of the Schizosaccharomyces pombe dis genes implicated in sister chromatid separation during mitosis.

Ohkura H et al. EMBO J 1988 May;7(5):1465-73

PMID:15507118 - An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.

Yuasa T et al. Genes Cells 2004 Nov;9(11):1069-82

PMID:11870212 - Kinesins klp5(+) and klp6(+) are required for normal chromosome movement in mitosis.

West RR et al. J Cell Sci 2002 Mar 01;115(Pt 5):931-40

PMID:25487150 - A PP1-PP2A phosphatase relay controls mitotic progression.

Grallert A et al. Nature 2015 Jan 01;517(7532):94-98

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16

PMID:34346498 - Loss of kinesin-8 improves the robustness of the self-assembled spindle in Schizosaccharomyces pombe.

Pineda-Santaella A et al. J Cell Sci 2021 Aug 15;134(16)

PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.

Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:24937146 - Targeting Alp7/TACC to the spindle pole body is essential for mitotic spindle assembly in fission yeast.

Tang NH et al. FEBS Lett 2014 Aug 25;588(17):2814-21

PMID:31427431 - Kinesin-8 and Dis1/TOG collaborate to limit spindle elongation from prophase to anaphase A for proper chromosome segregation in fission yeast.

Pinder C et al. J Cell Sci 2019 Sep 23;132(18)

PMID:15525536 - The S. pombe Cdc14-like phosphatase Clp1p regulates chromosome biorientation and interacts with Aurora kinase.

Trautmann S et al. Dev Cell 2004 Nov;7(5):755-62

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:21256022 - Ndc80 internal loop interacts with Dis1/TOG to ensure proper kinetochore-spindle attachment in fission yeast.

Hsu KS et al. Curr Biol 2011 Feb 08;21(3):214-20

PMID:11369198 - M phase-specific kinetochore proteins in fission yeast: microtubule-associating Dis1 and Mtc1 display rapid separation and segregation during anaphase.

Nakaseko Y et al. Curr Biol 2001 Apr 17;11(8):537-49

PMID:25375240 - The kinetochore protein Kis1/Eic1/Mis19 ensures the integrity of mitotic spindles through maintenance of kinetochore factors Mis6/CENP-I and CENP-A.

Hirai H et al. PLoS One 2014;9(11):e111905

PMID:18488015 - Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution.

Wilhelm BT et al. Nature 2008 Jun 26;453(7199):1239-43

PMID:18951025 - The SIN kinase Sid2 regulates cytoplasmic retention of the S. pombe Cdc14-like phosphatase Clp1.

Chen CT et al. Curr Biol 2008 Oct 28;18(20):1594-9

PMID:29021344 - A microtubule polymerase cooperates with the kinesin-6 motor and a microtubule cross-linker to promote bipolar spindle assembly in the absence of kinesin-5 and kinesin-14 in fission yeast.

Yukawa M et al. Mol Biol Cell 2017 Dec 01;28(25):3647-3659

PMID:17004072 - Chromosome segregation in fission yeast with mutations in the tubulin folding cofactor D.

Fedyanina OS et al. Curr Genet 2006 Nov;50(5):281-94

PMID:16085490 - Distinct nuclear and cytoplasmic functions of the S. pombe Cdc14-like phosphatase Clp1p/Flp1p and a role for nuclear shuttling in its regulation.

Trautmann S et al. Curr Biol 2005 Aug 09;15(15):1384-9

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:8389306 - Negative regulation of mitosis by the fission yeast protein phosphatase ppa2.

Kinoshita N et al. Genes Dev 1993 Jun;7(6):1059-71

PMID:36108046 - Recovery from spindle checkpoint-mediated arrest requires a novel Dnt1-dependent APC/C activation mechanism.

Bai S et al. PLoS Genet 2022 Sep;18(9):e1010397

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:1944266 - The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control.

Kinoshita N et al. Mol Cell Biol 1991 Dec;11(12):5839-47

PMID:12242294 - The mal2p protein is an essential component of the fission yeast centromere.

Jin QW et al. Mol Cell Biol 2002 Oct;22(20):7168-83

PMID:34080538 - Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth.

Krüger LK et al. Elife 2021 Jun 03;10

PMID:7628693 - p93dis1, which is required for sister chromatid separation, is a novel microtubule and spindle pole body-associating protein phosphorylated at the Cdc2 target sites.

Nabeshima K et al. Genes Dev 1995 Jul 01;9(13):1572-85

PMID:17442892 - The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast.

Kerres A et al. Mol Biol Cell 2007 Jul;18(7):2441-54

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:9078390 - Dissection of fission yeast microtubule associating protein p93Dis1: regions implicated in regulated localization and microtubule interaction.

Nakaseko Y et al. Genes Cells 1996 Jul;1(7):633-44

PMID:15280226 - Functional dissection of the gamma-tubulin complex by suppressor analysis of gtb1 and alp4 mutations in Schizosaccharomyces pombe.

Tange Y et al. Genetics 2004 Jul;167(3):1095-107

PMID:10398680 - Proper metaphase spindle length is determined by centromere proteins Mis12 and Mis6 required for faithful chromosome segregation.

Goshima G et al. Genes Dev 1999 Jul 01;13(13):1664-77

PMID:17352737 - The fission yeast DASH complex is essential for satisfying the spindle assembly checkpoint induced by defects in the inner-kinetochore proteins.

Kobayashi Y et al. Genes Cells 2007 Mar;12(3):311-28

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:21151990 - The fission yeast XMAP215 homolog Dis1p is involved in microtubule bundle organization.

Roque H et al. PLoS One 2010 Dec 02;5(12):e14201

PMID:16920624 - CDC2 phosphorylation of the fission yeast dis1 ensures accurate chromosome segregation.

Aoki K et al. Curr Biol 2006 Aug 22;16(16):1627-35

PMID:27872152 - An unconventional interaction between Dis1/TOG and Mal3/EB1 in fission yeast promotes the fidelity of chromosome segregation.

Matsuo Y et al. J Cell Sci 2016 Dec 15;129(24):4592-4606

PMID:30463883 - Suppressor Analysis Uncovers That MAPs and Microtubule Dynamics Balance with the Cut7/Kinesin-5 Motor for Mitotic Spindle Assembly in Schizosaccharomyces pombe .

Yukawa M et al. G3 (Bethesda) 2019 Jan 09;9(1):269-280

PMID:9802907 - Dynamics of centromeres during metaphase-anaphase transition in fission yeast: Dis1 is implicated in force balance in metaphase bipolar spindle.

Nabeshima K et al. Mol Biol Cell 1998 Nov;9(11):3211-25

PMID:20858896 - Activity of a C-terminal plant homeodomain (PHD) of Msc1 is essential for function.

Qiu X et al. J Biol Chem 2010 Nov 19;285(47):36828-35

PMID:31618856 - Two XMAP215/TOG Microtubule Polymerases, Alp14 and Dis1, Play Non-Exchangeable, Distinct Roles in Microtubule Organisation in Fission Yeast.

Yukawa M et al. Int J Mol Sci 2019 Oct 15;20(20)

PMID:11683390 - In vivo localisation of fission yeast cyclin-dependent kinase cdc2p and cyclin B cdc13p during mitosis and meiosis.

Decottignies A et al. J Cell Sci 2001 Jul;114(Pt 14):2627-40

PMID:23770679 - Microtubules and Alp7-Alp14 (TACC-TOG) reposition chromosomes before meiotic segregation.

Kakui Y et al. Nat Cell Biol 2013 Jul;15(7):786-96

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83