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protein coding gene - mdn1 (SPCC737.08) - rixosome complex midasin subunit Mdn1

Gene summary

Standard name
mdn1
Systematic ID
SPCC737.08
Product
rixosome complex midasin subunit Mdn1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94248
ORFeome ID
50/50A03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1900482..1914833 forward strand

Annotation

GO biological process

GO:1902626 - assembly of large subunit precursor of preribosome

References:

GO cellular component

GO:0005634 - nucleus

References:

GO:0120330 - rixosome complex

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GO molecular function

GO:0005524 - ATP binding

References:

GO:0016887 - ATP hydrolysis activity

References:

GO:0005509 - calcium ion binding

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Modification

MOD:00595 - monomannosylated residue

References:

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00048 - O4'-phospho-L-tyrosine

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Multi-locus phenotype

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

Protein features

PBO:0111792 - AAA family ATPase

PBO:0111761 - EF hand

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001168 - decreased ATPase activity

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Genotypes:

FYPO:0001137 - decreased mature 25S rRNA level

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Genotypes:

FYPO:0006782 - decreased protein level in large ribosomal subunit precursor

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Genotypes:

FYPO:0001645 - decreased protein-protein interaction

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0001136 - increased 27S rRNA precursor level

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Genotypes:

FYPO:0001135 - increased 35S rRNA precursor level

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Genotypes:

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0004300 - normal ATPase activity

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0006781 - resistance to Rbin-1

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Genotypes:

FYPO:0006780 - sensitive to Rbin-1

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF07728AAA_5ATPase_dyneun-rel_AAAPfam
PF17865AAA_lid_5Midasin_AAA_lid_5Pfam
PF17867AAA_lid_7AAA_lid_7Pfam
PF21108MDN1_4thMDN1_AAA_lid_4Pfam
cd00009AAACDD
cd01460vWA_midasinCDD
PS50234VWFAVWF_APROSITE profiles
SM00382AAAAAA+_ATPaseSMART
G3DSA:3.40.50.300:FF:000142CATH-FunFam
G3DSA:3.40.50.300:FF:000712CATH-FunFam
G3DSA:3.40.50.300:FF:001368CATH-FunFam
G3DSA:3.40.50.300:FF:002705CATH-FunFam
G3DSA:3.40.50.410:FF:000119CATH-FunFam
G3DSA:3.40.50.300P-loop_NTPaseCATH-Gene3D
G3DSA:3.40.50.410vWFA_dom_sfCATH-Gene3D
SSF52540P-loop_NTPaseSUPERFAMILY
SSF53300vWFA_dom_sfSUPERFAMILY
PTHR48103PANTHER
PIRSF010340MidasinMidasinPIRSF
CoilCOILS
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Negative-Polyelectrolytedisorder_predictionMobiDB-Negative-Polyelectrolyte
mobidb-lite-Polardisorder_predictionMobiDB-Polar
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte

Orthologs

References / Literature

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:27667686 - Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis.
Kawashima SA et al. Cell 2016 Oct 06;167(2):512-524.e14
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000002 - Comments
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26644575 - Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.
Halim A et al. Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15648-53
PMID:41974504 - Nuclear basket subunits Nup211 and Rsm1 influence RNA 3'-processing and transcription termination in fission yeast.
Bednor L et al. RNA 2026 Apr 13;
PMID:30318141 - Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis.
Chen Z et al. Cell 2018 Oct 18;175(3):822-834.e18
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6