protein coding gene - ctt1 (SPCC757.07c) - catalase

Gene summary

Standard name

ctt1

Systematic ID

SPCC757.07c

Product

catalase

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

cta1

UniProt ID

P55306

ORFeome ID

24/24H11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 56654..58833 reverse strand

Annotation

Protein features

Orthologs

• CAT (HGNC:1516) Homo sapiens
• ctt1 (SJAG_04823) Schizosaccharomyces japonicus
• CTA1 (YDR256C) Saccharomyces cerevisiae
• CTT1 (YGR088W) Saccharomyces cerevisiae

References / Literature

PMID:9154834 - Discrete roles of the Spc1 kinase and the Atf1 transcription factor in the UV response of Schizosaccharomyces pombe.

Degols G et al. Mol Cell Biol 1997 Jun;17(6):3356-63

PMID:9585505 - Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1.

Toone WM et al. Genes Dev 1998 May 15;12(10):1453-63

PMID:29900664 - Tschimganine and its derivatives extend the chronological life span of yeast via activation of the Sty1 pathway.

Hibi T et al. Genes Cells 2018 Jun 14;

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:23874237 - Modification of tRNA(Lys) UUU by elongator is essential for efficient translation of stress mRNAs.

Fernández-Vázquez J et al. PLoS Genet 2013;9(7):e1003647

PMID:10731689 - Role of Atf1 and Pap1 in the induction of the catalase gene of fission yeast schizosaccharomyces pombe.

Nakagawa CW et al. J Biochem 2000 Feb;127(2):233-8

PMID:18758731 - The role and regulation of Trxl, a cytosolic thioredoxin in Schizosaccharomyces pombe.

Song JY et al. J Microbiol 2008 Aug;46(4):408-14

PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.

Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:27005325 - Diverse fission yeast genes required for responding to oxidative and metal stress: Comparative analysis of glutathione-related and other defense gene deletions.

Pluskal T et al. Genes Cells 2016 Jun;21(6):530-42

PMID:26567340 - Genome-wide Screening of Regulators of Catalase Expression: ROLE OF A TRANSCRIPTION COMPLEX AND HISTONE AND tRNA MODIFICATION COMPLEXES ON ADAPTATION TO STRESS.

García P et al. J Biol Chem 2016 Jan 08;291(2):790-9

PMID:35416247 - Tschimganine has different targets for chronological lifespan extension and growth inhibition in fission yeast.

Ohtsuka H et al. Biosci Biotechnol Biochem 2022 May 24;86(6):775-779

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:23231582 - Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe.

Carter-O'Connell I et al. BMC Genomics 2012 Dec 12;13:697

PMID:10455235 - Schizosaccharomyces pombe homologue of glutathione peroxidase, which does not contain selenocysteine, is induced by several stresses and works as an antioxidant.

Yamada K et al. Yeast 1999 Aug;15(11):1125-32

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:28652406 - Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation.

Salat-Canela C et al. J Biol Chem 2017 Aug 18;292(33):13635-13644

PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.

Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:11179424 - Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway.

Buck V et al. Mol Biol Cell 2001 Feb;12(2):407-19

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:15645504 - Pro-oxidant action of phloxine B on fission yeast Schizosaccharomyces pombe.

Mutoh N et al. Yeast 2005 Jan 30;22(2):91-7

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:33225241 - The Hsp40 Mas5 Connects Protein Quality Control and the General Stress Response through the Thermo-sensitive Pyp1.

Boronat S et al. iScience 2020 Nov 20;23(11):101725

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:9718372 - Evidence for a novel MAPKKK-independent pathway controlling the stress activated Sty1/Spc1 MAP kinase in fission yeast.

Shieh JC et al. J Cell Sci 1998 Sep;111 ( Pt 18):2799-807

PB_REF:0000003 - Disease Association Curation

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:36174923 - Schizosaccharomyces pombe MAP kinase Sty1 promotes survival of Δppr10 cells with defective mitochondrial protein synthesis.

Hu Y et al. Int J Biochem Cell Biol 2022 Nov;152:106308

PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.

Larochelle M et al. J Cell Sci 2019 May 31;132(11)

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.

Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29

PMID:24118096 - Methionine sulphoxide reductases revisited: free methionine as a primary target of H₂O₂stress in auxotrophic fission yeast.

García-Santamarina S et al. Mol Microbiol 2013 Dec;90(5):1113-24

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:10428959 - Sin1: an evolutionarily conserved component of the eukaryotic SAPK pathway.

Wilkinson MG et al. EMBO J 1999 Aug 02;18(15):4210-21

PMID:24696293 - Ecl1 is activated by the transcription factor Atf1 in response to H2O2 stress in Schizosaccharomyces pombe.

Shimasaki T et al. Mol Genet Genomics 2014 Aug;289(4):685-93

PMID:10749922 - Multistep phosphorelay proteins transmit oxidative stress signals to the fission yeast stress-activated protein kinase.

Nguyen AN et al. Mol Biol Cell 2000 Apr;11(4):1169-81

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:14695938 - Pleiotropic phenotypes of fission yeast defective in ubiquinone-10 production. A study from the abc1Sp (coq8Sp) mutant.

Saiki R et al. Biofactors 2003;18(1-4):229-35

PMID:20919928 - Two-component mediated peroxide sensing and signal transduction in fission yeast.

Quinn J et al. Antioxid Redox Signal 2011 Jul 01;15(1):153-65

PMID:27227887 - The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast.

Ma N et al. PLoS One 2016;11(5):e0156239

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:9450957 - The Win1 mitotic regulator is a component of the fission yeast stress-activated Sty1 MAPK pathway.

Shieh JC et al. Mol Biol Cell 1998 Feb;9(2):311-22

PMID:16428309 - Effects of four oxidants, menadione, 1-chloro-2,4-dinitrobenzene, hydrogen peroxide and cumene hydroperoxide, on fission yeast Schizosaccharmoyces pombe.

Mutoh N et al. J Biochem 2005 Dec;138(6):797-804

PMID:22344694 - The transcription factors Pap1 and Prr1 collaborate to activate antioxidant, but not drug tolerance, genes in response to H2O2.

Calvo IA et al. Nucleic Acids Res 2012 Jun;40(11):4816-24

PMID:12221110 - Role of fission yeast Tup1-like repressors and Prr1 transcription factor in response to salt stress.

Greenall A et al. Mol Biol Cell 2002 Sep;13(9):2977-89

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:10940030 - Spy1, a histidine-containing phosphotransfer signaling protein, regulates the fission yeast cell cycle through the Mcs4 response regulator.

Aoyama K et al. J Bacteriol 2000 Sep;182(17):4868-74

PMID:9821290 - Stability and refractoriness of the high catalase activity in the oxidative-stress-resistant fission yeast Schizosaccharomyces pombe.

Sigler K et al. Folia Microbiol (Praha) 1998;43(4):369-72

PMID:38899862 - Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast PHO regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1.

Schwer B et al. mBio 2024 Jun 20;:e0125224

PMID:37956308 - Topoisomerase 1 facilitates nucleosome reassembly at stress genes during recovery.

Vega M et al. Nucleic Acids Res 2023 Dec 11;51(22):12161-12173

PMID:9136929 - The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle.

Shieh JC et al. Genes Dev 1997 Apr 15;11(8):1008-22

PMID:8537298 - Transcriptional regulation of catalase gene in the fission yeast Schizosaccharomyces pombe: molecular cloning of the catalase gene and northern blot analyses of the transcript.

Nakagawa CW et al. J Biochem 1995 Jul;118(1):109-16

PMID:33410907 - The fission yeast Pin1 peptidyl-prolyl isomerase promotes dissociation of Sty1 MAPK from RNA polymerase II and recruits Ssu72 phosphatase to facilitate oxidative stress induced transcription.

Wang YT et al. Nucleic Acids Res 2021 Jan 25;49(2):805-817

PMID:24521463 - A genetic approach to study H2O2 scavenging in fission yeast--distinct roles of peroxiredoxin and catalase.

Paulo E et al. Mol Microbiol 2014 Apr;92(2):246-57

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:29859088 - Using in vivo oxidation status of one- and two-component redox relays to determine H 2 O 2 levels linked to signaling and toxicity.

Domènech A et al. BMC Biol 2018 Jun 01;16(1):61

PMID:10348908 - A fission yeast gene (prr1(+)) that encodes a response regulator implicated in oxidative stress response.

Ohmiya R et al. J Biochem 1999 Jun;125(6):1061-6

PMID:16914721 - Upf1, an RNA helicase required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast.

Rodríguez-Gabriel MA et al. Mol Cell Biol 2006 Sep;26(17):6347-56

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:25122751 - Binding of the transcription factor Atf1 to promoters serves as a barrier to phase nucleosome arrays and avoid cryptic transcription.

García P et al. Nucleic Acids Res 2014;42(16):10351-9

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:32957622 - Catalase T-Deficient Fission Yeast Meiocytes Show Resistance to Ionizing Radiation.

Muhtadi R et al. Antioxidants (Basel) 2020 Sep 17;9(9)

PMID:10380645 - The role of catalase in hydrogen peroxide resistance in fission yeast Schizosaccharomyces pombe.

Mutoh N et al. Can J Microbiol 1999 Feb;45(2):125-9

PMID:19625445 - Role for RACK1 orthologue Cpc2 in the modulation of stress response in fission yeast.

Núñez A et al. Mol Biol Cell 2009 Sep;20(18):3996-4009

PMID:20829365 - Pma1, a P-type proton ATPase, is a determinant of chronological life span in fission yeast.

Ito H et al. J Biol Chem 2010 Nov 05;285(45):34616-20

PMID:8824588 - The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast.

Wilkinson MG et al. Genes Dev 1996 Sep 15;10(18):2289-301

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:18223116 - Key function for the CCAAT-binding factor Php4 to regulate gene expression in response to iron deficiency in fission yeast.

Mercier A et al. Eukaryot Cell 2008 Mar;7(3):493-508

PMID:23525001 - Reversible thiol oxidation in the H2O2-dependent activation of the transcription factor Pap1.

Calvo IA et al. J Cell Sci 2013 May 15;126(Pt 10):2279-84

PMID:22212525 - Chronological lifespan extension by Ecl1 family proteins depends on Prr1 response regulator in fission yeast.

Ohtsuka H et al. Genes Cells 2012 Jan;17(1):39-52

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:8371123 - Response of catalase activity and membrane fluidity of aerobically grown Schizosaccharomyces pombe and Saccharomyces cerevisiae to aeration and the presence of substrates.

Gille G et al. J Gen Microbiol 1993 Jul;139(7):1627-34