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protein coding gene - aah1 (SPCC757.12) - cell wall (1->3)-alpha-glucan biosynthesis protein Aah1

Gene summary

Standard name
aah1
Systematic ID
SPCC757.12
Product
cell wall (1->3)-alpha-glucan biosynthesis protein Aah1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74922
ORFeome ID
26/26D05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 72876..75522 forward strand

Annotation

PBO:0001601 - 3.2.1.1

GO biological process

GO:0070600 - fungal-type cell wall (1->3)-alpha-glucan biosynthetic process

References:

GO:0071940 - fungal-type cell wall assembly

References:

GO cellular component

GO:0009897 - external side of plasma membrane

References:

GO:0009277 - fungal-type cell wall

References:

GO molecular function

GO:0004134 - 4-alpha-glucanotransferase activity

References:

Modification

MOD:00689 - disulfide crosslinked residues

References:

MOD:00818 - glycosylphosphatidylinositolated residue

References:

MOD:00006 - N-glycosylated residue

References:

MOD:00171 - N-seryl-glycosylphosphatidylinositolethanolamine

References:

Multi-locus phenotype

FYPO:0001971 - abnormal cell separation after cytokinesis resulting in chained cells

References:

Genotypes:

FYPO:0002946 - abnormal cell wall

References:

Genotypes:

FYPO:0001081 - decreased cell wall alpha-glucan level

References:

Genotypes:

FYPO:0002265 - decreased cell wall galactomannan level

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0001036 - delaminated cell wall during vegetative growth

References:

Genotypes:

FYPO:0003133 - galactomannan absent from cell wall

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Genotypes:

FYPO:0004860 - increased cell wall beta-glucan level

References:

Genotypes:

FYPO:0001035 - increased cell wall thickness during vegetative growth

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0006117 - multiseptate spheroid vegetative cell

References:

Genotypes:

FYPO:0000673 - normal septum assembly

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0004103 - viable spherical vegetative cell

References:

Genotypes:

Protein sequence feature

SO:0000418 - signal_peptide

References:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0009036 - resistance to benzamidine

References:

Genotypes:

FYPO:0000073 - resistance to caffeine

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

References:

Genotypes:

FYPO:0002693 - resistance to diamide

References:

Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0005193 - resistance to torin1

References:

Genotypes:

FYPO:0000830 - resistance to vanadate

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

References:

Genotypes:

FYPO:0002328 - sensitive to terbinafine

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

FYPO:0002104 - viable vegetative cell with normal cell shape

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0000110 - orthologs cannot be distinguished

Protein features

IDNameInterPro nameDB name
PF00128Alpha-amylaseGH13_cat_domPFAM
PF09260A_amylase_dom_CA_amylase_C_domPFAM
cd11319AmyAc_euk_AmyACDD
SM00642aamyGH13_cat_domSMART
G3DSA:2.60.40.1180:FF:000037FUNFAM
G3DSA:3.20.20.80:FF:000120FUNFAM
SSF51445(Trans)glycosidasesGH_hydrolase_sfSUPERFAMILY
SSF51011Glycosyl hydrolase domainSUPERFAMILY
G3DSA:3.20.20.80GlycosidasesGENE3D
G3DSA:2.60.40.1180Glyco_hydro_bGENE3D
PTHR10357ALPHA-AMYLASE FAMILY MEMBERPANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder

Orthologs

References / Literature

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:12845604 - Genome-wide identification of fungal GPI proteins.
De Groot PW et al. Yeast 2003 Jul 15;20(9):781-96
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
GO_REF:0000117 - Electronic Gene Ontology annotations created by ARBA machine learning models
PMID:40668835 - α-glucan remodeling by GH13-domain enzymes shapes fungal cell wall architecture.
Jacob A et al. Proc Natl Acad Sci U S A 2025 Jul 22;122(29):e2505509122
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PB_REF:0000007 - Prediction of GPI-anchored proteins with pointer neural networks
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:16751704 - An alpha-amylase homologue, aah3, encodes a GPI-anchored membrane protein required for cell wall integrity and morphogenesis in Schizosaccharomyces pombe.
Morita T et al. Biosci Biotechnol Biochem 2006 Jun;70(6):1454-63