protein coding gene - wtf5 (SPCC794.02) - wtf antidote-like meiotic drive suppressor Wtf5

Gene summary

Standard name

wtf5

Systematic ID

SPCC794.02

Product

wtf antidote-like meiotic drive suppressor Wtf5

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

wts5, wtf4

UniProt ID

Q8TF80

ORFeome ID

51/51C12

Characterisation status

meiotic driver

Feature type

mRNA gene

Genomic location

chromosome III: 243855..245622 forward strand

Annotation

Protein features

References / Literature

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:38097609 - Ubiquitination-mediated Golgi-to-endosome sorting determines the toxin-antidote duality of fission yeast wtf meiotic drivers.

Zheng JX et al. Nat Commun 2023 Dec 14;14(1):8334

GO_REF:0000002 - Comments

PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.

Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:12952871 - Retrotransposons and their recognition of pol II promoters: a comprehensive survey of the transposable elements from the complete genome sequence of Schizosaccharomyces pombe.

Bowen NJ et al. Genome Res 2003 Sep;13(9):1984-97

PMID:32032353 - Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all display high gamete-killing efficiency.

Bravo Núñez MA et al. PLoS Genet 2020 Feb;16(2):e1008350

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:28631610 - A large gene family in fission yeast encodes spore killers that subvert Mendel's law.

Hu W et al. Elife 2017 Jun 20;6

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:30991417 - Killer Meiotic Drive and Dynamic Evolution of the wtf Gene Family.

Eickbush MT et al. Mol Biol Evol 2019 Jun 01;36(6):1201-1214

PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Anver S et al. EMBO Rep 2014 Aug;15(8):894-902

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12