protein coding gene - cnb1 (SPCC830.06) - serine/threonine protein phosphatase PP2B (calcineurin B) regulatory subunit

Gene summary

Standard name

cnb1

Systematic ID

SPCC830.06

Product

serine/threonine protein phosphatase PP2B (calcineurin B) regulatory subunit

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q9UU93

ORFeome ID

10/10G10

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 2192091..2193378 forward strand

Annotation

Protein features

Orthologs

• PPP3R1 (HGNC:9317) Homo sapiens
• PPP3R2 (HGNC:9318) Homo sapiens
• cnb1 (SJAG_03793) Schizosaccharomyces japonicus
• CNB1 (YKL190W) Saccharomyces cerevisiae

References / Literature

PMID:22806344 - Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.

Ryuko S et al. Mol Genet Genomics 2012 Aug;287(8):651-62

PMID:25081204 - Negative feedback regulation of calcineurin-dependent Prz1 transcription factor by the CaMKK-CaMK1 axis in fission yeast.

Cisneros-Barroso E et al. Nucleic Acids Res 2014 Sep;42(15):9573-87

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:27053105 - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.

Burr R et al. J Biol Chem 2016 Jun 03;291(23):12171-83

PMID:30332655 - Paxillin-Mediated Recruitment of Calcineurin to the Contractile Ring Is Required for the Correct Progression of Cytokinesis in Fission Yeast.

Martín-García R et al. Cell Rep 2018 Oct 16;25(3):772-783.e4

PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Pan X et al. BMC Genomics 2012 Nov 23;13:662

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:19672306 - Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Calvo IA et al. PLoS One 2009 Aug 12;4(8):e6619

GO_REF:0000002 - Comments

PMID:23934882 - Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast.

Viana RA et al. Genetics 2013 Oct;195(2):421-32

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:26628015 - Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism.

Zhang X et al. Kobe J Med Sci 2015 Oct 09;61(2):E54-63

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:15657058 - The role of the regulatory subunit of fission yeast calcineurin for in vivo activity and its relevance to FK506 sensitivity.

Sio SO et al. J Biol Chem 2005 Apr 01;280(13):12231-8

PMID:34133210 - Cdk1 phosphorylation of fission yeast paxillin inhibits its cytokinetic ring localization.

Mangione MC et al. Mol Biol Cell 2021 Aug 15;32(17):1534-1544

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:23956092 - [Cnb1 involved in cytokinesis in Schizosaccharomyces pombe].

Fan JQ et al. Yi Chuan 2013 Aug;35(8):1030-9

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

Sun LL et al. PLoS Genet 2013;9(8):e1003715