protein coding gene - pop5 (SPCC830.09c) - RNase P and RNase MRP subunit Pop5

Gene summary

Standard name: pop5
Systematic ID: SPCC830.09c
Product: RNase P and RNase MRP subunit Pop5
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9UU90
ORFeome ID: 03/03D06
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome III: 2197726..2199855 reverse strand

Annotation

GO biological process

GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

References:

PMID:25401760

GO:0001682 - tRNA 5'-leader removal

References:

GO_REF:0000033

GO:0008033 - tRNA processing

References:

PMID:25401760

GO cellular component

GO:0005655 - nucleolar ribonuclease P complex

References:

GO_REF:0000024

GO:0000172 - ribonuclease MRP complex

References:

PMID:25401760

GO molecular function

GO:0000171 - ribonuclease MRP activity

References:

PMID:25401760

GO:0004526 - ribonuclease P activity

References:

GO_REF:0000003

GO:0033204 - ribonuclease P RNA binding

References:

GO_REF:0000033

Quantitative gene expression

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000951 - inviable small vegetative cell

References:

PMID:23697806

Genotypes:

pop5delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

pop5delta

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF01900	RNase_P_Rpp14	Pop5/Rpp14/Rnp2-like	Pfam
G3DSA:3.30.70.3250:FF:000004			CATH-FunFam
G3DSA:3.30.70.3250		Rnp2-like_sf	CATH-Gene3D
SSF160350		Rnp2-like_sf	SUPERFAMILY
PTHR15441			PANTHER
PIRSF023803	Ribonuclease_P_prd	RNase_P/MRP_POP5	PIRSF
MF_00755	RNase_P_2	Pop5/Rpp14/Rnp2-like	HAMAP

Orthologs

POP5 (HGNC:17689) Homo sapiens
pop5 (SJAG_03796) Schizosaccharomyces japonicus
POP5 (YAL033W) Saccharomyces cerevisiae

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:25401760 - RNase MRP cleaves pre-tRNASer-Met in the tRNA maturation pathway.: Saito Y et al. PLoS One 2014;9(11):e112488
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.: Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.: Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000003 - Gene Ontology annotation based on Enzyme Commission mapping
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:6262315 - Partial purification of RNase P from Schizosaccharomyces pombe.: Kline L et al. J Biol Chem 1981 May 25;256(10):5058-63