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protein coding gene - sua5 (SPCC895.03c) - mitochondrial tRNA N6-threonyl-carbamoyl-adenosine (t6A) Sua5

Gene summary

Standard name
sua5
Systematic ID
SPCC895.03c
Product
mitochondrial tRNA N6-threonyl-carbamoyl-adenosine (t6A) Sua5
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94530
ORFeome ID
19/19E08
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 998797..1000311 reverse strand

Annotation

Disease association

MONDO:0030476 - Galloway-Mowat syndrome 10

References:

GO biological process

GO:0072670 - mitochondrial tRNA threonylcarbamoyladenosine modification

References:

GO:0006450 - regulation of translational fidelity

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO molecular function

GO:0003725 - double-stranded RNA binding

References:

GO:0061710 - L-threonylcarbamoyladenylate synthase activity

References:

GO:0000049 - tRNA binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

Multi-locus phenotype

FYPO:0000284 - large and small daughter nuclei, with unequal mitotic sister chromatid segregation

References:

Genotypes:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002113 - inviable curved vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002273 - inviable vegetative cell with abnormal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01300Sua5_yciO_yrdCSua5-like_domPfam
PF03481Sua5_CSua5_CPfam
PS51163YRDCSua5-like_domPROSITE profiles
G3DSA:3.90.870.10:FF:000008CATH-FunFam
G3DSA:3.40.50.11030Sua5/YwlC_CCATH-Gene3D
G3DSA:3.90.870.10CATH-Gene3D
SSF55821DHBP_synth_RibB-like_a/b_domSUPERFAMILY
PTHR17490TC-AMP_synthase_SUA5PANTHER
PIRSF004930Tln_factor_SUA5T(6)A37_SUA5PIRSF
TIGR00057Sua5-like_domNCBIFAM

Orthologs

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000002 - Comments
PMID:30967422 - Negative Regulation of the Mis17-Mis6 Centromere Complex by mRNA Decay Pathway and EKC/KEOPS Complex in Schizosaccharomyces pombe .
Xu X et al. G3 (Bethesda) 2019 Jun 05;9(6):1815-1823
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25038083 - Cross kingdom functional conservation of the core universally conserved threonylcarbamoyladenosine tRNA synthesis enzymes.
Thiaville PC et al. Eukaryot Cell 2014 Sep;13(9):1222-31
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000116 - Automatic Gene Ontology annotation based on Rhea mapping.
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs