protein coding gene - cut15 (SPCC962.03c) - importin alpha family nuclear import signal receptor adaptor Cut15

Gene summary

Standard name

cut15

Systematic ID

SPCC962.03c

Product

importin alpha family nuclear import signal receptor adaptor Cut15

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O14063

ORFeome ID

26/26A09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 549555..552147 reverse strand

Annotation

Protein features

Orthologs

• KPNA1 (HGNC:6394) Homo sapiens
• KPNA5 (HGNC:6398) Homo sapiens
• KPNA6 (HGNC:6399) Homo sapiens
• cut15 (SJAG_04411) Schizosaccharomyces japonicus
• SRP1 (YNL189W) Saccharomyces cerevisiae

References / Literature

PMID:38780300 - Nitrogen availability is important for preventing catastrophic mitosis in fission yeast.

Zemlianski V et al. J Cell Sci 2024 May 23;

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:9649518 - A screen for genes involved in the anaphase proteolytic pathway identifies tsm1(+), a novel Schizosaccharomyces pombe gene important for microtubule integrity.

Grishchuk EL et al. Genetics 1998 Jul;149(3):1251-64

PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99

PMID:15937127 - The fission yeast Schizosaccharomyces pombe has two importin-alpha proteins, Imp1p and Cut15p, which have common and unique functions in nucleocytoplasmic transport and cell cycle progression.

Umeda M et al. Genetics 2005 Sep;171(1):7-21

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:7622450 - Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes.

Enenkel C et al. J Biol Chem 1995 Jul 14;270(28):16499-502

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:17615301 - Multiple conserved domains of the nucleoporin Nup124p and its orthologs Nup1p and Nup153 are critical for nuclear import and activity of the fission yeast Tf1 retrotransposon.

Sistla S et al. Mol Biol Cell 2007 Sep;18(9):3692-708

PMID:18362178 - Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis.

Nakazawa N et al. J Cell Biol 2008 Mar 24;180(6):1115-31

PMID:36799444 - Inner nuclear membrane proteins Lem2 and Bqt4 interact with different lipid synthesis enzymes in fission yeast.

Hirano Y et al. J Biochem 2023 Jun 30;174(1):33-46

PMID:9740803 - Mutations in fission yeast Cut15, an importin alpha homolog, lead to mitotic progression without chromosome condensation.

Matsusaka T et al. Curr Biol 1998 Sep 10;8(18):1031-4

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:15161942 - The nucleolus is involved in mRNA export from the nucleus in fission yeast.

Ideue T et al. J Cell Sci 2004 Jun 15;117(Pt 14):2887-95

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:8395535 - Identification of seven new cut genes involved in Schizosaccharomyces pombe mitosis.

Samejima I et al. J Cell Sci 1993 May;105 ( Pt 1):135-43

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:11927555 - The fission yeast NIMA kinase Fin1p is required for spindle function and nuclear envelope integrity.

Krien MJ et al. EMBO J 2002 Apr 02;21(7):1713-22

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:24790093 - CDK-dependent phosphorylation of Alp7-Alp14 (TACC-TOG) promotes its nuclear accumulation and spindle microtubule assembly.

Okada N et al. Mol Biol Cell 2014 Jul 01;25(13):1969-82

PMID:25330182 - Characterization of the nuclear import mechanism of the CCAAT-regulatory subunit Php4.

Khan MG et al. PLoS One 2014;9(10):e110721

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323