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protein coding gene - yme1 (SPCC965.04c) - mitochondrial inner membrane i-AAA protease complex subunit Yme1

Gene summary

Standard name
yme1
Systematic ID
SPCC965.04c
Product
mitochondrial inner membrane i-AAA protease complex subunit Yme1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
ppp36
UniProt ID
O59824
ORFeome ID
46/46G05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 2286794..2289320 reverse strand

Annotation

Disease association

MONDO:0015011 - optic atrophy 11

References:

GO biological process

GO:0141164 - mitochondrial protein quality control

References:

GO:0051604 - protein maturation

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GO cellular component

GO:0031942 - i-AAA complex

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GO:0005739 - mitochondrion

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GO molecular function

GO:0005524 - ATP binding

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GO:0016887 - ATP hydrolysis activity

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GO:0004176 - ATP-dependent peptidase activity

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GO:0004222 - metalloendopeptidase activity

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Modification

MOD:00595 - mannosylated residue

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Multi-locus phenotype

FYPO:0001310 - normal viability in stationary phase

References:

Genotypes:

Protein features

PBO:0111792 - AAA family ATPase

Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003743 - decreased cell population growth during glucose starvation

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Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009099 - decreased cell population growth on mannitol carbon source

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Genotypes:

FYPO:0000565 - increased cellular respiration

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Genotypes:

FYPO:0007737 - increased mitochondrial membrane potential

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Genotypes:

FYPO:0008360 - increased mitophagy during stationary phase

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0009080 - sensitive to calcofluor and sodium dodecyl sulfate

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

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Genotypes:

FYPO:0001214 - sensitive to potassium chloride

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01434Peptidase_M41Peptidase_M41PFAM
PF17862AAA_lid_3AAA_lid_3PFAM
PF21232Yme1-like_NYme1-like_NPFAM
PF00004AAAATPase_AAA_corePFAM
cd19501RecA-like_FtsHCDD
SM00382AAA_5AAA+_ATPaseSMART
G3DSA:1.10.8.60:FF:000001FUNFAM
G3DSA:3.40.50.300:FF:000175FUNFAM
G3DSA:1.20.58.760:FF:000002FUNFAM
SSF140990FtsH protease domain-likePeptidase_M41-likeSUPERFAMILY
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
G3DSA:1.10.8.60GENE3D
G3DSA:1.20.58.760Peptidase M41Peptidase_M41-likeGENE3D
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
PTHR23076METALLOPROTEASE M41 FTSHPANTHER
MF_01458FtsHFtsHHAMAP
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMOBIDB-Low-complexity

Orthologs

References / Literature

PMID:38692277 - A dynamin superfamily-like pseudoenzyme coordinates with MICOS to promote cristae architecture.
Kumar A et al. Curr Biol 2024 Apr 24;
GO_REF:0000051 - S. pombe keyword mapping
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:26644575 - Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.
Halim A et al. Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15648-53
PMID:12524335 - Genetic and biochemical basis for viability of yeast lacking mitochondrial genomes.
Kominsky DJ et al. Genetics 2002 Dec;162(4):1595-604
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:26182355 - Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1.
Spiller MP et al. Biosci Rep 2015 Mar 17;35(3)
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
GO_REF:0000002 - Comments
PMID:38269097 - Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology.
Morozumi Y et al. iScience 2024 Jan 19;27(1):108777
PMID:16491466 - Construction of a protease-deficient strain set for the fission yeast Schizosaccharomyces pombe, useful for effective production of protease-sensitive heterologous proteins.
Idiris A et al. Yeast 2006 Jan 30;23(2):83-99