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protein coding gene - alr1 (SPCC965.08c) - alanine racemase Alr1

Gene summary

Standard name
alr1
Systematic ID
SPCC965.08c
Product
alanine racemase Alr1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O59828
ORFeome ID
17/17G03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 2297387..2299231 reverse strand

Annotation

PBO:0005824 - 5.1.1.1

GO biological process

GO:0055130 - D-alanine catabolic process

References:

GO:0036088 - D-serine catabolic process

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GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

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GO molecular function

GO:0008784 - alanine racemase activity

References:

GO:0030170 - pyridoxal phosphate binding

References:

Modification

MOD:00128 - N6-pyridoxal phosphate-L-lysine

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Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000121 - abnormal sporulation

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0000095 - sensitive to bleomycin

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000022 - shmoo with long tip

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0000055 - no apparent S. cerevisiae ortholog

Warnings

PBO:0000085 - possible horizontal transfer

References:

Protein features

IDNameInterPro nameDB name
PF00842Ala_racemase_CAla_racemase_CPFAM
PF01168Ala_racemase_NAla_racemase_NPFAM
cd06827PLPDE_III_AR_proteobactCDD
PS00395ALANINE_RACEMASEAla_racemase_pyridoxalP-BSPROSITE_PATTERNS
SM01005Ala_racemase_C_2Ala_racemase_CSMART
PR00992ALARACEMASEAla_racemasePRINTS
G3DSA:2.40.37.10:FF:000002FUNFAM
G3DSA:3.20.20.10:FF:000002FUNFAM
SSF51419PLP-binding barrelPLP-binding_barrelSUPERFAMILY
SSF50621Alanine racemase C-terminal domain-likeAla_racemase/Decarboxylase_CSUPERFAMILY
G3DSA:3.20.20.10Alanine racemasePLP-binding_barrelGENE3D
G3DSA:2.40.37.10Lyase, Ornithine Decarboxylase; Chain A, domain 1Ala_racemase/Decarboxylase_CGENE3D
PTHR30511ALANINE RACEMASEAla_racemasePANTHER
MF_01201Ala_racemaseAla_racemaseHAMAP
TIGR00492alrAla_racemaseNCBIFAM

References / Literature

PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.
Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:11244061 - Functional characterization of alanine racemase from Schizosaccharomyces pombe: a eucaryotic counterpart to bacterial alanine racemase.
Uo T et al. J Bacteriol 2001 Apr;183(7):2226-33
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83