protein coding gene - rad16 (SPCC970.01) - DNA repair endonuclease XPF

Gene summary

Standard name

rad16

Systematic ID

SPCC970.01

Product

DNA repair endonuclease XPF

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

rad10, rad20, swi9

UniProt ID

P36617

ORFeome ID

47/47F11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 514796..518097 reverse strand

Annotation

Protein features

Orthologs

• ERCC4 (HGNC:3436) Homo sapiens
• rad16 (SJAG_02556) Schizosaccharomyces japonicus
• RAD1 (YPL022W) Saccharomyces cerevisiae

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:24861625 - Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.

Mahyous Saeyd SA et al. Nucleic Acids Res 2014 Jul;42(12):7734-47

PMID:15654094 - A novel recombination pathway initiated by the Mre11/Rad50/Nbs1 complex eliminates palindromes during meiosis in Schizosaccharomyces pombe.

Farah JA et al. Genetics 2005 Mar;169(3):1261-74

PMID:27687866 - Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast.

Noguchi C et al. Cell Cycle 2017 Jan 02;16(1):45-58

PMID:8709952 - The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe.

Hegde V et al. Mol Gen Genet 1996 Jun 24;251(4):483-92

PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.

Chen JS et al. Yeast 2016 Sep;33(9):507-17

PMID:21670547 - Fission yeast homologs of human XPC and CSB, rhp41 and rhp26, are involved in transcription-coupled repair of methyl methanesulfonate-induced DNA damage.

Kanamitsu K et al. Genes Genet Syst 2011;86(2):83-91

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:32692737 - CRL4Cdt2 ubiquitin ligase regulates Dna2 and Rad16 (XPF) nucleases by targeting Pxd1 for degradation.

Zhang JM et al. PLoS Genet 2020 Jul;16(7):e1008933

PMID:23335786 - Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells.

Almeida H et al. Nucleic Acids Res 2013 Mar 01;41(5):3056-67

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.

Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595

PMID:19798055 - Failed gene conversion leads to extensive end processing and chromosomal rearrangements in fission yeast.

Tinline-Purvis H et al. EMBO J 2009 Nov 04;28(21):3400-12

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:22365419 - The Schizosaccharomyces pombe AlkB homolog Abh1 exhibits AP lyase activity but no demethylase activity.

Korvald H et al. DNA Repair (Amst) 2012 May 01;11(5):453-62

PMID:6587363 - Genes required for initiation and resolution steps of mating-type switching in fission yeast.

Egel R et al. Proc Natl Acad Sci U S A 1984 Jun;81(11):3481-5

PMID:23188080 - The fission yeast MRN complex tethers dysfunctional telomeres for NHEJ repair.

Reis CC et al. EMBO J 2012 Dec 12;31(24):4576-86

PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.

Maki T et al. PLoS Genet 2018 May;14(5):e1007424

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:7254221 - Spontaneous and UV-induced recombination in radiation-sensitive mutants of Schizosaccharomyces pombe.

Grossenbacher-Grunder AM et al. Mutat Res 1981 Mar;81(1):37-48

PMID:11719193 - Mus81-Eme1 are essential components of a Holliday junction resolvase.

Boddy MN et al. Cell 2001 Nov 16;107(4):537-48

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:24719968 - Switching genes in Schizosaccharomyces pombe.

Gutz H et al. Curr Genet 1985;9(5):325-31

PMID:24192486 - The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.

Fontebasso Y et al. DNA Repair (Amst) 2013 Dec;12(12):1011-23

PMID:9658208 - Sensitivity to cisplatin and platinum-containing compounds of Schizosaccharomyces pombe rad mutants.

Perego P et al. Mol Pharmacol 1998 Jul;54(1):213-9

PMID:25777942 - A novel protein, Rsf1/Pxd1, is critical for the single-strand annealing pathway of double-strand break repair in Schizosaccharomyces pombe.

Wang H et al. Mol Microbiol 2015 Jun;96(6):1211-25

PMID:25203555 - Fission yeast Pxd1 promotes proper DNA repair by activating Rad16XPF and inhibiting Dna2.

Zhang JM et al. PLoS Biol 2014 Sep;12(9):e1001946

PMID:19470480 - Ctp1 and Exonuclease 1, alternative nucleases regulated by the MRN complex, are required for efficient meiotic recombination.

Farah JA et al. Proc Natl Acad Sci U S A 2009 Jun 09;106(23):9356-61

PMID:25293972 - Increased meiotic crossovers and reduced genome stability in absence of Schizosaccharomyces pombe Rad16 (XPF).

Mastro TL et al. Genetics 2014 Dec;198(4):1457-72

PMID:15485909 - Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.

Morikawa H et al. Mol Cell Biol 2004 Nov;24(21):9401-13

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:18270439 - Involvement of 3-methyladenine DNA glycosylases Mag1p and Mag2p in base excision repair of methyl methanesulfonate-damaged DNA in the fission yeast Schizosaccharomyces pombe.

Kanamitsu K et al. Genes Genet Syst 2007 Dec;82(6):489-94

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:2598273 - Some of the swi genes of Schizosaccharomyces pombe also have a function in the repair of radiation damage.

Schmidt H et al. Curr Genet 1989 Aug;16(2):89-94

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:12628934 - Pathway utilization in response to a site-specific DNA double-strand break in fission yeast.

Prudden J et al. EMBO J 2003 Mar 17;22(6):1419-30

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:22064477 - The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast.

Groocock LM et al. Mol Cell Biol 2012 Jan;32(2):276-87

PMID:32034465 - Genetic investigation of formaldehyde-induced DNA damage response in Schizosaccharomyces pombe.

Anandarajan V et al. Curr Genet 2020 Jun;66(3):593-605

PMID:8114734 - The rad16 gene of Schizosaccharomyces pombe: a homolog of the RAD1 gene of Saccharomyces cerevisiae.

Carr AM et al. Mol Cell Biol 1994 Mar;14(3):2029-40

PMID:166019 - Genetic control of radiation sensitivity in Schizosaccharomyces pombe.

Nasim A et al. Genetics 1975 Apr;79(4):573-82

PMID:22665798 - Induction of a G1-S checkpoint in fission yeast.

Bøe CA et al. Proc Natl Acad Sci U S A 2012 Jun 19;109(25):9911-6

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81