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protein coding gene - wtf9 (SPCC970.11c) - wtf antidote-like meiotic drive suppressor Wtf9

Gene summary

Standard name
wtf9
Systematic ID
SPCC970.11c
Product
wtf antidote-like meiotic drive suppressor Wtf9
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
wts9, wtf2
UniProt ID
O74564
ORFeome ID
52/52B10
Characterisation status
meiotic driver
Feature type
mRNA gene
Genomic location
chromosome III: 487167..489016 forward strand

Annotation

GO biological process

GO:0110134 - meiotic drive

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0140549 - spore inner membrane

References:

GO:0005774 - vacuolar membrane

References:

Protein features

PBO:0111903 - wtf element

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001489 - inviable vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0016878 - Schizosaccharomyces pombe specific

Protein features

IDNameInterPro nameDB name
PF03303WTFWTFPfam
Transmembrane alpha helixDeepTMHMM
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:38097609 - Ubiquitination-mediated Golgi-to-endosome sorting determines the toxin-antidote duality of fission yeast wtf meiotic drivers.
Zheng JX et al. Nat Commun 2023 Dec 14;14(1):8334
PMID:32032353 - Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all display high gamete-killing efficiency.
Bravo Núñez MA et al. PLoS Genet 2020 Feb;16(2):e1008350
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000002 - Comments
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
PMID:12952871 - Retrotransposons and their recognition of pol II promoters: a comprehensive survey of the transposable elements from the complete genome sequence of Schizosaccharomyces pombe.
Bowen NJ et al. Genome Res 2003 Sep;13(9):1984-97