protein coding gene - mis18 (SPCC970.12) - kinetochore protein Mis18

Gene summary

Standard name

mis18

Systematic ID

SPCC970.12

Product

kinetochore protein Mis18

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q9P802

ORFeome ID

07/07E03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 513931..514807 reverse strand

Annotation

Protein features

Orthologs

• MIS18A (HGNC:1286) Homo sapiens
• OIP5 (HGNC:20300) Homo sapiens
• mis18 (SJAG_05273) Schizosaccharomyces japonicus

References / Literature

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:31371524 - Subunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex.

Korntner-Vetter M et al. Life Sci Alliance 2019 Aug;2(4)

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:28827290 - Kinetochore Components Required for Centromeric Chromatin Assembly Are Impacted by Msc1 in Schizosaccharomyces pombe .

Gao C et al. Genetics 2017 Oct;207(2):559-569

PMID:28904333 - The Ino80 complex mediates epigenetic centromere propagation via active removal of histone H3.

Choi ES et al. Nat Commun 2017 Sep 13;8(1):529

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:19217404 - Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin.

Pidoux AL et al. Mol Cell 2009 Feb 13;33(3):299-311

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:24774534 - Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex.

Hayashi T et al. Genes Cells 2014 Jul;19(7):541-54

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:17352737 - The fission yeast DASH complex is essential for satisfying the spindle assembly checkpoint induced by defects in the inner-kinetochore proteins.

Kobayashi Y et al. Genes Cells 2007 Mar;12(3):311-28

PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.

Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608

PMID:26942680 - Licensing of Centromeric Chromatin Assembly through the Mis18α-Mis18β Heterotetramer.

Nardi IK et al. Mol Cell 2016 Mar 03;61(5):774-787

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:28977643 - Regulation of mitotic recombination between DNA repeats in centromeres.

Zafar F et al. Nucleic Acids Res 2017 Nov 02;45(19):11222-11235

PMID:23028377 - Factors that promote H3 chromatin integrity during transcription prevent promiscuous deposition of CENP-A(Cnp1) in fission yeast.

Choi ES et al. PLoS Genet 2012 Sep;8(9):e1002985

PMID:19217403 - Fission yeast Scm3 mediates stable assembly of Cnp1/CENP-A into centromeric chromatin.

Williams JS et al. Mol Cell 2009 Feb 13;33(3):287-98

PMID:18362178 - Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis.

Nakazawa N et al. J Cell Biol 2008 Mar 24;180(6):1115-31

PMID:15369671 - Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.

Hayashi T et al. Cell 2004 Sep 17;118(6):715-29

PMID:36200823 - The chromatin remodeler RSC prevents ectopic CENP-A propagation into pericentromeric heterochromatin at the chromatin boundary.

Tsunemine S et al. Nucleic Acids Res 2022 Oct 28;50(19):10914-10928

PMID:24789708 - Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly.

Subramanian L et al. Open Biol 2014 Apr 30;4(4):140043

PMID:37714149 - Direct recruitment of Mis18 to interphase spindle pole bodies promotes CENP-A chromatin assembly.

London N et al. Curr Biol 2023 Oct 09;33(19):4187-4201.e6

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:29925533 - Fission Yeast CENP-C (Cnp3) Plays a Role in Restricting the Site of CENP-A Accumulation.

Suma M et al. G3 (Bethesda) 2018 Jul 31;8(8):2723-2733

PMID:25375240 - The kinetochore protein Kis1/Eic1/Mis19 ensures the integrity of mitotic spindles through maintenance of kinetochore factors Mis6/CENP-I and CENP-A.

Hirai H et al. PLoS One 2014;9(11):e111905

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:26921242 - Centromere localization and function of Mis18 requires Yippee-like domain-mediated oligomerization.

Subramanian L et al. EMBO Rep 2016 Apr;17(4):496-507

PMID:29804820 - Mis16 Switches Function from a Histone H4 Chaperone to a CENP-A Cnp1 -Specific Assembly Factor through Eic1 Interaction.

An S et al. Structure 2018 Jul 03;26(7):960-971.e4

PMID:32318758 - Centromere targeting of Mis18 requires the interaction with DNA and H2A-H2B in fission yeast.

Zhang M et al. Cell Mol Life Sci 2021 Jan;78(1):373-384

PMID:34460892 - Transcriptome sequencing and screening of genes related to glucose availability in Schizosaccharomyces pombe by RNA-seq analysis.

Tarhan Ç et al. Genet Mol Biol 2021;44(3):e20200245