PomBase home

protein coding gene - med31 (SPCP31B10.03c) - mediator complex subunit Med31

Gene summary

Standard name
med31
Systematic ID
SPCP31B10.03c
Product
mediator complex subunit Med31
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
soh1, sep10
UniProt ID
Q9USH1
ORFeome ID
03/03D03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 525859..526748 reverse strand

Annotation

Comment

PBO:0000206 - deletion mutant expression profiling

References:

GO biological process

GO:0060261 - positive regulation of transcription initiation by RNA polymerase II

References:

GO cellular component

GO:0070847 - core mediator complex

References:

GO:0016592 - mediator complex

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0003713 - transcription coactivator activity

References:

Multi-locus phenotype

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0007639 - increased DNA damage at rDNA during G0

References:

Genotypes:

FYPO:0004032 - increased protein localization to chromatin at rDNA

References:

Genotypes:

FYPO:0002430 - inviable after spore germination, multiple cell divisions

References:

Genotypes:

FYPO:0004495 - inviable branched, swollen, elongated, multiseptate vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0007553 - normal G1 to G0 transition

References:

Genotypes:

FYPO:0007629 - normal viability during G0

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0002023 - abnormal septum morphology during vegetative growth

References:

Genotypes:

FYPO:0005853 - aggregated filamentous actin in cytoplasm

References:

Genotypes:

FYPO:0000134 - branched, elongated, multiseptate cell

References:

Genotypes:

FYPO:0007642 - decreased histone H3-K9 dimethylation at rDNA during G0

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0000584 - decreased sporulation frequency

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0001886 - meiotic cell cycle entry and sporulation in haploid

References:

Genotypes:

FYPO:0003717 - normal actin cytoskeleton morphology during vegetative growth

References:

Genotypes:

FYPO:0007553 - normal G1 to G0 transition

References:

Genotypes:

FYPO:0000962 - normal growth on hydrogen peroxide

References:

Genotypes:

FYPO:0000961 - normal growth on sorbitol

References:

Genotypes:

FYPO:0006213 - normal septum morphology

References:

Genotypes:

FYPO:0007629 - normal viability during G0

References:

Genotypes:

FYPO:0004263 - normal viability in stationary phase during nitrogen limitation

References:

Genotypes:

FYPO:0002047 - resistance to heat shock during nitrogen starvation

References:

Genotypes:

FYPO:0001408 - sensitive to heat shock

References:

Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

FYPO:0005889 - sensitive to sodium chloride

References:

Genotypes:

FYPO:0000280 - sterile

References:

Genotypes:

FYPO:0002457 - viable curved elongated vegetative cell with abnormal septum

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF05669Med31Mediator_Med31PFAM
G3DSA:1.10.10.1340:FF:000001FUNFAM
G3DSA:1.10.10.1340Mediator of RNA polymerase II, submodule Med31 (Soh1)Med31_sfGENE3D
PTHR13186MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31Mediator_Med31PANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Polyampholytedisorder_predictionMOBIDB-Polyampholyte

Orthologs

References / Literature

PMID:28467824 - Core Mediator structure at 3.4 Å extends model of transcription initiation complex.
Nozawa K et al. Nature 2017 May 11;545(7653):248-251
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:15829570 - Impairment of the TFIIH-associated CDK-activating kinase selectively affects cell cycle-regulated gene expression in fission yeast.
Lee KM et al. Mol Biol Cell 2005 Jun;16(6):2734-45
PMID:19473263 - The involvement of the Schizosaccharomyces pombe sep9/spt8 gene in the regulation of septum cleavage.
Batta G et al. FEMS Yeast Res 2009 Aug;9(5):757-67
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:10392445 - Eleven novel sep genes of Schizosaccharomyces pombe required for efficient cell separation and sexual differentiation.
Grallert A et al. Yeast 1999 Jun 15;15(8):669-86
PMID:15356001 - The Soh1/MED31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae Mediator.
Linder T et al. J Biol Chem 2004 Nov 19;279(47):49455-9
PMID:18310102 - Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways.
Linder T et al. Nucleic Acids Res 2008 May;36(8):2489-504
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:17922236 - Genomic expression patterns in cell separation mutants of Schizosaccharomyces pombe defective in the genes sep10 ( + ) and sep15 ( + ) coding for the Mediator subunits Med31 and Med8.
Miklos I et al. Mol Genet Genomics 2008 Mar;279(3):225-38
PMID:28241144 - Mediator structure and rearrangements required for holoenzyme formation.
Tsai KL et al. Nature 2017 Apr 13;544(7649):196-201
PMID:12471453 - The Schizosaccharomyces pombe genes sep10 and sep11 encode putative general transcriptional regulators involved in multiple cellular processes.
Szilagyi Z et al. Mol Genet Genomics 2002 Dec;268(4):553-62
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:27738016 - RNA interference is essential for cellular quiescence.
Roche B et al. Science 2016 Nov 11;354(6313)
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623