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protein coding gene - cox1 (SPMIT.01) - cytochrome c oxidase subunit 1

Gene summary

Standard name
cox1
Systematic ID
SPMIT.01
Product
cytochrome c oxidase subunit 1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P07657
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome Mitochondrial: 4885..8817 forward strand

Annotation

Disease association

MONDO:0044970 - mitochondrial disease

References:

GO biological process

GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen

References:

GO:1902600 - proton transmembrane transport

References:

GO cellular component

GO:0005743 - mitochondrial inner membrane

References:

GO:0045277 - respiratory chain complex IV

References:

GO molecular function

GO:0005507 - copper ion binding

References:

GO:0004129 - cytochrome-c oxidase activity

References:

GO:0020037 - heme binding

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00115COX1Cyt_C_Oxase_1Pfam
cd01663Cyt_c_Oxidase_ICyt_c_oxase_su1_domCDD
PS00077COX1_CUBCyt_c_Oxase_su1_BSPROSITE patterns
PS50855COX1Cyt_c_oxase-like_su1_domPROSITE profiles
PR01165CYCOXIDASEICyt_C_Oxase_1PRINTS
G3DSA:1.20.210.10:FF:000004CATH-FunFam
G3DSA:1.20.210.10Cyt_c_oxase-like_su1_sfCATH-Gene3D
SSF81442Cyt_c_oxase-like_su1_sfSUPERFAMILY
PTHR10422Cyt_C_Oxase_1PANTHER
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:39289458 - Characterization of Shy1, the Schizosaccharomyces pombe homolog of human SURF1.
Luo Y et al. Sci Rep 2024 Sep 17;14(1):21678
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:31364709 - Intraspecific Diversity of Fission Yeast Mitochondrial Genomes.
Tao YT et al. Genome Biol Evol 2019 Aug 01;11(8):2312-2329
PMID:17614284 - The chromatin-remodeling factor FACT contributes to centromeric heterochromatin independently of RNAi.
Lejeune E et al. Curr Biol 2007 Jul 17;17(14):1219-24
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:38499152 - Sls1 and Mtf2 mediate the assembly of the Mrh5C complex required for activation of cox1 mRNA translation.
Wang Y et al. J Biol Chem 2024 Mar 16;:107176
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:38604460 - The Schizosaccharomyces pombe DEAD-box protein Mss116 is required for mitoribosome assembly and mitochondrial translation.
Wang Y et al. Mitochondrion 2024 Apr 09;76:101881
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:31053642 - The yeast protein Mam33 functions in the assembly of the mitochondrial ribosome.
Hillman GA et al. J Biol Chem 2019 Jun 21;294(25):9813-9829
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:37939086 - Structure and function of the S. pombe III-IV-cyt c supercomplex.
Moe A et al. Proc Natl Acad Sci U S A 2023 Nov 14;120(46):e2307697120
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:36797353 - Cryo-EM structure and function of S. pombe complex IV with bound respiratory supercomplex factor.
Moe A et al. Commun Chem 2023 Feb 16;6(1):32
PMID:33049028 - Schizosaccharomyces pombe Ppr10 is required for mitochondrial translation.
Liu Z et al. FEMS Microbiol Lett 2020 Oct 21;367(19)
PMID:36089751 - Schizosaccharomyces pombe Sls1 is primarily required for cox1 mRNA translation.
Wang Y et al. Yeast 2022 Oct;39(10):521-534
PMID:22349564 - Schizosaccharomyces pombe homologs of the Saccharomyces cerevisiae mitochondrial proteins Cbp6 and Mss51 function at a post-translational step of respiratory complex biogenesis.
Kühl I et al. Mitochondrion 2012 May;12(3):381-90
PMID:29458562 - The fission yeast Schizosaccharomyces pombe Mtf2 is required for mitochondrial cox1 gene expression.
Liu J et al. Microbiology (Reading) 2018 Mar;164(3):400-409
PMID:34119521 - Schizosaccharomyces pombe Ppr10 and Mpa1 together mediate mitochondrial translational initiation.
Luo Y et al. J Biol Chem 2021 Jul;297(1):100869
PMID:30715423 - Queuine links translational control in eukaryotes to a micronutrient from bacteria.
Müller M et al. Nucleic Acids Res 2019 Apr 23;47(7):3711-3727
PMID:35666203 - A yeast suppressor screen links Coa4 to the mitochondrial copper delivery pathway for cytochrome c oxidase.
Swaminathan AB et al. Genetics 2022 Jul 30;221(4)
PMID:34634819 - Translational activators and mitoribosomal isoforms cooperate to mediate mRNA-specific translation in Schizosaccharomyces pombe mitochondria.
Herbert CJ et al. Nucleic Acids Res 2021 Nov 08;49(19):11145-11166
PMID:28334955 - The Schizosaccharomyces pombe PPR protein Ppr10 associates with a novel protein Mpa1 and acts as a mitochondrial translational activator.
Wang Y et al. Nucleic Acids Res 2017 Apr 07;45(6):3323-3340
PMID:40427588 - The Insertion Domain of Mti2 Facilitates the Association of Mitochondrial Initiation Factors with Mitoribosomes in Schizosaccharomyces pombe .
Luo Y et al. Biomolecules 2025 May 10;15(5)
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:28082314 - A CMC1 -knockout reveals translation-independent control of human mitochondrial complex IV biogenesis.
Bourens M et al. EMBO Rep 2017 Mar;18(3):477-494
GO_REF:0000002 - Comments
PMID:11250894 - Oxa1p acts as a general membrane insertion machinery for proteins encoded by mitochondrial DNA.
Hell K et al. EMBO J 2001 Mar 15;20(6):1281-8