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protein coding gene - cox1-I1b (SPMIT.02) - mitochondrial DNA binding endonuclease Cox1-I1b (intron-encoded)

Gene summary

Standard name
cox1-I1b
Systematic ID
SPMIT.02
Product
mitochondrial DNA binding endonuclease Cox1-I1b (intron-encoded)
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P22191
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome Mitochondrial: 5290..6444 forward strand

Annotation

GO biological process

GO:0006314 - intron homing

References:

GO cellular component

GO:0000262 - mitochondrial chromosome

References:

GO molecular function

GO:0003677 - DNA binding

References:

GO:0004519 - endonuclease activity

References:

Genome organisation

PBO:0005879 - protein in cox1 intron-1

Modification

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0005880 - intronic ORF

Protein features

IDNameInterPro nameDB name
PF00961LAGLIDADG_1LAGLIDADG_domPfam
G3DSA:3.10.28.10:FF:000033CATH-FunFam
G3DSA:3.10.28.10Homing_endonuclCATH-Gene3D
SSF55608Homing_endonuclSUPERFAMILY
PTHR36181LAGLIDADG_EndonucleasePANTHER

Orthologs

References / Literature

PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
GO_REF:0000002 - Comments
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:31364709 - Intraspecific Diversity of Fission Yeast Mitochondrial Genomes.
Tao YT et al. Genome Biol Evol 2019 Aug 01;11(8):2312-2329