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protein coding gene - cox1-I2b (SPMIT.03) - mitochondrial DNA binding endonuclease (intron encoded)

Gene summary

Standard name
cox1-I2b
Systematic ID
SPMIT.03
Product
mitochondrial DNA binding endonuclease (intron encoded)
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P22190
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome Mitochondrial: 6965..7816 forward strand

Annotation

GO biological process

GO:0006314 - intron homing

References:

GO cellular component

GO:0000262 - mitochondrial chromosome

References:

GO molecular function

GO:0003677 - DNA binding

References:

GO:0004519 - endonuclease activity

References:

Genome organisation

PBO:0005881 - protein in cox1 intron-2

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0005880 - intronic ORF

Protein features

IDNameInterPro nameDB name
PF00961LAGLIDADG_1LAGLIDADG_domPfam
G3DSA:3.10.28.10Homing_endonuclCATH-Gene3D
SSF55608Homing_endonuclSUPERFAMILY
PTHR36181LAGLIDADG_EndonucleasePANTHER

Orthologs

References / Literature

PMID:38269097 - Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology.
Morozumi Y et al. iScience 2024 Jan 19;27(1):108777
PMID:31364709 - Intraspecific Diversity of Fission Yeast Mitochondrial Genomes.
Tao YT et al. Genome Biol Evol 2019 Aug 01;11(8):2312-2329
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
GO_REF:0000002 - Comments
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016