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protein coding gene - cob1 (SPMIT.05) - cytochrome b, Cob1

Gene summary

Standard name
cob1
Systematic ID
SPMIT.05
Product
cytochrome b, Cob1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
cob, cytb
UniProt ID
P05501
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome Mitochondrial: 10175..13877 forward strand

Annotation

Disease association

MONDO:0004069 - inborn mitochondrial metabolism disorder

References:

MONDO:0005066 - metabolic disease

References:

MONDO:0015448 - mitochondrial complex III deficiency

References:

MONDO:0044970 - mitochondrial disease

References:

GO biological process

GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c

References:

GO:1902600 - proton transmembrane transport

References:

GO cellular component

GO:0005743 - mitochondrial inner membrane

References:

GO:0045275 - respiratory chain complex III

References:

GO molecular function

GO:0020037 - heme binding

References:

GO:0008121 - quinol-cytochrome-c reductase activity

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0007122 - decreased mitochondrial respiratory chain complex assembly

References:

Genotypes:

FYPO:0007623 - decreased mitochondrial respiratory chain complex III assembly

References:

Genotypes:

FYPO:0007624 - decreased mitochondrial respiratory chain complex IV assembly

References:

Genotypes:

FYPO:0000441 - resistance to antimycin A

References:

Genotypes:

FYPO:0000440 - sensitive to antimycin A

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00032Cytochrom_B_CCyt_b/b6_CPfam
PF00033Cytochrome_BCyt_b/b6_NPfam
cd00284Cytochrome_b_NCytochrome_b_N_euk/bacCDD
PS51002CYTB_NTERCyt_b/b6_NPROSITE profiles
PS51003CYTB_CTERCyt_b/b6_CPROSITE profiles
G3DSA:1.20.810.10Cytb/b6-like_sfCATH-Gene3D
SSF81342Di-haem_cyt_TMSUPERFAMILY
SSF81648Cyt_b/b6_C_sfSUPERFAMILY
PTHR19271PANTHER
PIRSF038885COBCytochrome_bPIRSF
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:34119521 - Schizosaccharomyces pombe Ppr10 and Mpa1 together mediate mitochondrial translational initiation.
Luo Y et al. J Biol Chem 2021 Jul;297(1):100869
PMID:33049028 - Schizosaccharomyces pombe Ppr10 is required for mitochondrial translation.
Liu Z et al. FEMS Microbiol Lett 2020 Oct 21;367(19)
PMID:28334955 - The Schizosaccharomyces pombe PPR protein Ppr10 associates with a novel protein Mpa1 and acts as a mitochondrial translational activator.
Wang Y et al. Nucleic Acids Res 2017 Apr 07;45(6):3323-3340
PMID:38499152 - Sls1 and Mtf2 mediate the assembly of the Mrh5C complex required for activation of cox1 mRNA translation.
Wang Y et al. J Biol Chem 2024 Mar 16;:107176
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:3169239 - Two changes of the same nucleotide confer resistance to diuron and antimycin in the mitochondrial cytochrome b gene of Schizosaccharomyces pombe.
Weber S et al. FEBS Lett 1988 Sep 12;237(1-2):31-4
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:34634819 - Translational activators and mitoribosomal isoforms cooperate to mediate mRNA-specific translation in Schizosaccharomyces pombe mitochondria.
Herbert CJ et al. Nucleic Acids Res 2021 Nov 08;49(19):11145-11166
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:40427588 - The Insertion Domain of Mti2 Facilitates the Association of Mitochondrial Initiation Factors with Mitoribosomes in Schizosaccharomyces pombe .
Luo Y et al. Biomolecules 2025 May 10;15(5)
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
PMID:1309808 - Identification of heme and copper ligands in subunit I of the cytochrome bo complex in Escherichia coli.
Minagawa J et al. J Biol Chem 1992 Jan 25;267(3):2096-104
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000003 - Disease Association Curation
PMID:21727087 - A genome wide study in fission yeast reveals nine PPR proteins that regulate mitochondrial gene expression.
Kühl I et al. Nucleic Acids Res 2011 Oct;39(18):8029-41
PMID:39289458 - Characterization of Shy1, the Schizosaccharomyces pombe homolog of human SURF1.
Luo Y et al. Sci Rep 2024 Sep 17;14(1):21678
PMID:22349564 - Schizosaccharomyces pombe homologs of the Saccharomyces cerevisiae mitochondrial proteins Cbp6 and Mss51 function at a post-translational step of respiratory complex biogenesis.
Kühl I et al. Mitochondrion 2012 May;12(3):381-90
PMID:29458562 - The fission yeast Schizosaccharomyces pombe Mtf2 is required for mitochondrial cox1 gene expression.
Liu J et al. Microbiology (Reading) 2018 Mar;164(3):400-409
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:31364709 - Intraspecific Diversity of Fission Yeast Mitochondrial Genomes.
Tao YT et al. Genome Biol Evol 2019 Aug 01;11(8):2312-2329
PMID:30715423 - Queuine links translational control in eukaryotes to a micronutrient from bacteria.
Müller M et al. Nucleic Acids Res 2019 Apr 23;47(7):3711-3727
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:37939086 - Structure and function of the S. pombe III-IV-cyt c supercomplex.
Moe A et al. Proc Natl Acad Sci U S A 2023 Nov 14;120(46):e2307697120
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105