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protein coding gene - atp6 (SPMIT.07) - F1-FO ATP synthase membrane subunit, Atp6

Gene summary

Standard name
atp6
Systematic ID
SPMIT.07
Product
F1-FO ATP synthase membrane subunit, Atp6
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P21535
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome Mitochondrial: 14670..15531 forward strand

Annotation

Disease association

MONDO:0010080 - familial infantile bilateral striatal necrosis

References:

MONDO:0016814 - maternally-inherited Leigh syndrome

References:

MONDO:0044970 - mitochondrial disease

References:

MONDO:0010774 - striatonigral degeneration, infantile, mitochondrial

References:

GO biological process

GO:0042776 - proton motive force-driven mitochondrial ATP synthesis

References:

GO cellular component

GO:0099617 - matrix side of mitochondrial inner membrane

References:

GO:0045259 - proton-transporting ATP synthase complex

References:

GO molecular function

GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism

References:

GO:0005198 - structural molecule activity

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00119ATP-synt_AATP_synth_F0_asuPFAM
cd00310ATP-synt_Fo_a_6CDD
PS00449ATPASE_AATP_synth_F0_asu_ASPROSITE_PATTERNS
PR00123ATPASEAATP_synth_F0_asuPRINTS
G3DSA:1.20.120.220:FF:000003FUNFAM
SSF81336F1F0 ATP synthase subunit AF0_ATP_A_sfSUPERFAMILY
G3DSA:1.20.120.220ATP synthase, F0 complex, subunit AF0_ATP_A_sfGENE3D
PTHR11410ATP SYNTHASE SUBUNIT AATP_synth_F0_asu_bact/mtPANTHER
MF_01393ATP_synth_a_bactATP_synth_F0_asuHAMAP
TIGR01131ATP_synt_6_or_AATP_synth_F0_asuNCBIFAM

Orthologs

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:33049028 - Schizosaccharomyces pombe Ppr10 is required for mitochondrial translation.
Liu Z et al. FEMS Microbiol Lett 2020 Oct 21;367(19)
PMID:39289458 - Characterization of Shy1, the Schizosaccharomyces pombe homolog of human SURF1.
Luo Y et al. Sci Rep 2024 Sep 17;14(1):21678
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:38499152 - Sls1 and Mtf2 mediate the assembly of the Mrh5C complex required for activation of cox1 mRNA translation.
Wang Y et al. J Biol Chem 2024 Mar 16;:107176
PMID:31364709 - Intraspecific Diversity of Fission Yeast Mitochondrial Genomes.
Tao YT et al. Genome Biol Evol 2019 Aug 01;11(8):2312-2329
PMID:34119521 - Schizosaccharomyces pombe Ppr10 and Mpa1 together mediate mitochondrial translational initiation.
Luo Y et al. J Biol Chem 2021 Jul;297(1):100869
PB_REF:0000003 - Disease Association Curation
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21727087 - A genome wide study in fission yeast reveals nine PPR proteins that regulate mitochondrial gene expression.
Kühl I et al. Nucleic Acids Res 2011 Oct;39(18):8029-41
PMID:17135288 - Prohibitins interact genetically with Atp23, a novel processing peptidase and chaperone for the F1Fo-ATP synthase.
Osman C et al. Mol Biol Cell 2007 Feb;18(2):627-35
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:28334955 - The Schizosaccharomyces pombe PPR protein Ppr10 associates with a novel protein Mpa1 and acts as a mitochondrial translational activator.
Wang Y et al. Nucleic Acids Res 2017 Apr 07;45(6):3323-3340
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:40427588 - The Insertion Domain of Mti2 Facilitates the Association of Mitochondrial Initiation Factors with Mitoribosomes in Schizosaccharomyces pombe .
Luo Y et al. Biomolecules 2025 May 10;15(5)
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80