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protein coding gene - var1 (SPMIT.08) - mitochondrial ribosomal protein subunit S3

Gene summary

Standard name
var1
Systematic ID
SPMIT.08
Product
mitochondrial ribosomal protein subunit S3
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
rps3, urfa
UniProt ID
P21547
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome Mitochondrial: 15956..16639 forward strand

Annotation

GO biological process

GO:0032543 - mitochondrial translation

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GO cellular component

GO:0005763 - mitochondrial small ribosomal subunit

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GO molecular function

GO:0003735 - structural constituent of ribosome

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Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000684 - decreased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0001938 - decreased cytochrome-c oxidase activity

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Genotypes:

FYPO:0003394 - decreased mitochondrial electron transport, NADH to ubiquinone

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Genotypes:

FYPO:0004020 - decreased mitochondrial electron transport, succinate to ubiquinone

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Genotypes:

FYPO:0004015 - mitochondria present in normal numbers

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Genotypes:

FYPO:0004016 - normal cellular mtDNA level

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Genotypes:

FYPO:0004017 - normal cytochrome-c oxidase activity

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Genotypes:

FYPO:0004018 - normal mitochondrial electron transport, NADH to ubiquinone

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Genotypes:

FYPO:0004019 - normal mitochondrial electron transport, succinate to ubiquinone

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Genotypes:

FYPO:0000441 - resistance to antimycin A

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Genotypes:

Taxonomic conservation

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF05316VAR1Ribosomal_uS3m_funPFAM

Orthologs

References / Literature

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:39289458 - Characterization of Shy1, the Schizosaccharomyces pombe homolog of human SURF1.
Luo Y et al. Sci Rep 2024 Sep 17;14(1):21678
PMID:31364709 - Intraspecific Diversity of Fission Yeast Mitochondrial Genomes.
Tao YT et al. Genome Biol Evol 2019 Aug 01;11(8):2312-2329
PMID:2065367 - Characterization of a novel open reading frame, urf a, in the mitochondrial genome of fission yeast: correlation of urf a mutations with a mitochondrial mutator phenotype and a possible role of frameshifting in urf a expression.
Zimmer M et al. Curr Genet 1991 Feb;19(2):95-102
GO_REF:0000002 - Comments
PMID:38499152 - Sls1 and Mtf2 mediate the assembly of the Mrh5C complex required for activation of cox1 mRNA translation.
Wang Y et al. J Biol Chem 2024 Mar 16;:107176
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:40427588 - The Insertion Domain of Mti2 Facilitates the Association of Mitochondrial Initiation Factors with Mitoribosomes in Schizosaccharomyces pombe .
Luo Y et al. Biomolecules 2025 May 10;15(5)
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:33049028 - Schizosaccharomyces pombe Ppr10 is required for mitochondrial translation.
Liu Z et al. FEMS Microbiol Lett 2020 Oct 21;367(19)
PMID:28334955 - The Schizosaccharomyces pombe PPR protein Ppr10 associates with a novel protein Mpa1 and acts as a mitochondrial translational activator.
Wang Y et al. Nucleic Acids Res 2017 Apr 07;45(6):3323-3340