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protein coding gene - cox2 (SPMIT.11) - cytochrome c oxidase subunit 2

Gene summary

Standard name
cox2
Systematic ID
SPMIT.11
Product
cytochrome c oxidase subunit 2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P21534
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome Mitochondrial: 18475..19309 forward strand

Annotation

Disease association

MONDO:0044970 - mitochondrial disease

References:

GO biological process

GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen

References:

GO:1902600 - proton transmembrane transport

References:

GO cellular component

GO:0005743 - mitochondrial inner membrane

References:

GO:0031966 - mitochondrial membrane

References:

GO:0045277 - respiratory chain complex IV

References:

GO molecular function

GO:0005507 - copper ion binding

References:

GO:0004129 - cytochrome-c oxidase activity

References:

Modification

MOD:00047 - O-phospho-L-threonine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00116COX2CcO_II-like_CPfam
PF02790COX2_TMCyt_c_oxidase_su2_TM_domPfam
cd13912CcO_II_CCcO_II_CCDD
PS00078COX2Copper_CuAPROSITE patterns
PS50857COX2_CUACcO_II-like_CPROSITE profiles
PS50999COX2_TMCyt_c_oxidase_su2_TM_domPROSITE profiles
PR01166CYCOXIDASEIIPRINTS
G3DSA:1.10.287.90:FF:000004CATH-FunFam
G3DSA:2.60.40.420:FF:000001CATH-FunFam
G3DSA:1.10.287.90Cyt_c_oxidase_su2_TM_sfCATH-Gene3D
G3DSA:2.60.40.420CupredoxinCATH-Gene3D
SSF49503CupredoxinSUPERFAMILY
SSF81464Cyt_c_oxidase_su2_TM_sfSUPERFAMILY
PTHR22888CcO_IIPANTHER
TIGR02866CoxBCyt_c_oxidase_su2NCBIFAM
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:29458562 - The fission yeast Schizosaccharomyces pombe Mtf2 is required for mitochondrial cox1 gene expression.
Liu J et al. Microbiology (Reading) 2018 Mar;164(3):400-409
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:39289458 - Characterization of Shy1, the Schizosaccharomyces pombe homolog of human SURF1.
Luo Y et al. Sci Rep 2024 Sep 17;14(1):21678
PMID:21727087 - A genome wide study in fission yeast reveals nine PPR proteins that regulate mitochondrial gene expression.
Kühl I et al. Nucleic Acids Res 2011 Oct;39(18):8029-41
PMID:37939086 - Structure and function of the S. pombe III-IV-cyt c supercomplex.
Moe A et al. Proc Natl Acad Sci U S A 2023 Nov 14;120(46):e2307697120
PMID:16911509 - The COX18 gene, involved in mitochondrial biogenesis, is functionally conserved and tightly regulated in humans and fission yeast.
Gaisne M et al. FEMS Yeast Res 2006 Sep;6(6):869-82
PMID:22139357 - H₂O₂ stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4.
Di Y et al. EMBO J 2012 Feb 01;31(3):563-75
PMID:33049028 - Schizosaccharomyces pombe Ppr10 is required for mitochondrial translation.
Liu Z et al. FEMS Microbiol Lett 2020 Oct 21;367(19)
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:40427588 - The Insertion Domain of Mti2 Facilitates the Association of Mitochondrial Initiation Factors with Mitoribosomes in Schizosaccharomyces pombe .
Luo Y et al. Biomolecules 2025 May 10;15(5)
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:20133687 - Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.
Takeda K et al. Proc Natl Acad Sci U S A 2010 Feb 23;107(8):3540-5
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28334955 - The Schizosaccharomyces pombe PPR protein Ppr10 associates with a novel protein Mpa1 and acts as a mitochondrial translational activator.
Wang Y et al. Nucleic Acids Res 2017 Apr 07;45(6):3323-3340
PMID:36797353 - Cryo-EM structure and function of S. pombe complex IV with bound respiratory supercomplex factor.
Moe A et al. Commun Chem 2023 Feb 16;6(1):32
PMID:34119521 - Schizosaccharomyces pombe Ppr10 and Mpa1 together mediate mitochondrial translational initiation.
Luo Y et al. J Biol Chem 2021 Jul;297(1):100869
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:31364709 - Intraspecific Diversity of Fission Yeast Mitochondrial Genomes.
Tao YT et al. Genome Biol Evol 2019 Aug 01;11(8):2312-2329
PMID:23892058 - Interactions between peptidyl tRNA hydrolase homologs and the ribosomal release factor Mrf1 in S. pombe mitochondria.
Dujeancourt L et al. Mitochondrion 2013 Nov;13(6):871-80
PMID:22349564 - Schizosaccharomyces pombe homologs of the Saccharomyces cerevisiae mitochondrial proteins Cbp6 and Mss51 function at a post-translational step of respiratory complex biogenesis.
Kühl I et al. Mitochondrion 2012 May;12(3):381-90
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
PMID:39932033 - Saccharomyces cerevisiae Dmo2p is required for the stability and maturation of newly translated Cox2p.
Soares MAKM et al. FEBS J 2025 Feb 11;
PMID:30715423 - Queuine links translational control in eukaryotes to a micronutrient from bacteria.
Müller M et al. Nucleic Acids Res 2019 Apr 23;47(7):3711-3727
PMID:24403053 - Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase.
Bourens M et al. Hum Mol Genet 2014 Jun 01;23(11):2901-13
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:24177952 - The mitochondrial genome of the fission yeast Schizosaccharomyces pombe : 5. Characterization of mitochondrial deletion mutants.
Ahne F et al. Curr Genet 1984 Sep;8(7):517-24
GO_REF:0000002 - Comments
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:18782833 - The human mitochondrial ribosome recycling factor is essential for cell viability.
Rorbach J et al. Nucleic Acids Res 2008 Oct;36(18):5787-99
PMID:34634819 - Translational activators and mitoribosomal isoforms cooperate to mediate mRNA-specific translation in Schizosaccharomyces pombe mitochondria.
Herbert CJ et al. Nucleic Acids Res 2021 Nov 08;49(19):11145-11166
PMID:38499152 - Sls1 and Mtf2 mediate the assembly of the Mrh5C complex required for activation of cox1 mRNA translation.
Wang Y et al. J Biol Chem 2024 Mar 16;:107176