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protein coding gene - mat2-Pi (SPMTR.02) - silenced P-specific transcription factor Pi

Gene summary

Standard name
mat2-Pi
Systematic ID
SPMTR.02
Product
silenced P-specific transcription factor Pi
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
mat-Pi, matPi, mat-Pm, mat2-Pm, matPm, mei1
UniProt ID
P10842
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome Mating type region: 3861..4368 forward strand

Annotation

GO biological process

GO:0051728 - cell cycle switching, mitotic to meiotic cell cycle

References:

GO:0071444 - cellular response to pheromone

References:

GO:0007531 - mating type determination

References:

GO:0140538 - negative regulation of conjugation with zygote

References:

GO:0045944 - positive regulation of transcription by RNA polymerase II

References:

GO:0034504 - protein localization to nucleus

References:

GO:0110044 - regulation of cell cycle switching, mitotic to meiotic cell cycle

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0005634 - nucleus

References:

GO:0062071 - Pi Mi complex

References:

GO molecular function

GO:0003677 - DNA binding

References:

GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

References:

GO:0005515 - protein binding

References:

Multi-locus phenotype

FYPO:0001043 - increased mating efficiency

References:

Genotypes:

FYPO:0001890 - increased RNA level

References:

Genotypes:

FYPO:0001886 - meiotic cell cycle entry and sporulation in haploid

References:

Genotypes:

FYPO:0000590 - normal sporulation

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000015 - RNA absent

References:

PomGeneEx:0000011 - RNA level increased

References:

PBO:0125049 - RNA level increased

References:

PomGeneEx:0000014 - RNA present

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000475 - abnormally arrested meiosis

References:

Genotypes:

FYPO:0002224 - abnormally arrested meiotic cell cycle

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Genotypes:

FYPO:0000927 - abolished horsetail movement

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Genotypes:

FYPO:0000474 - abolished meiosis

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Genotypes:

FYPO:0002044 - abolished premeiotic DNA replication

References:

Genotypes:

FYPO:0006349 - abolished protein localization to chromatin at promoter

References:

Genotypes:

FYPO:0006674 - abolished protein localization to nucleus during mating

References:

Genotypes:

FYPO:0000583 - abolished sporulation

References:

Genotypes:

FYPO:0001503 - decreased alpha,alpha-trehalase activity during sporulation

References:

Genotypes:

FYPO:0001504 - decreased cellular trehalose level during sporulation

References:

Genotypes:

FYPO:0002020 - increased RNA level during nitrogen starvation

References:

Genotypes:

FYPO:0000760 - normal mating

References:

Genotypes:

FYPO:0001147 - normal mating efficiency

References:

Genotypes:

FYPO:0002052 - normal sporulation frequency

References:

Genotypes:

FYPO:0001996 - RNA absent from cell during nitrogen starvation

References:

Genotypes:

Warnings

PBO:0092002 - this gene is located in the silent mating type region mat2 and is therefore not expressed. It is only transcribed when at the mat1 locus, which is the mating type configuration of h+ cells. The S. pombe reference strain is h- mating type and express h- specific mating genes from the mat1 locus. The silenced mat2 genes are therefore annotated with mat1 h+ specific information

Protein features

IDNameInterPro nameDB name
PF05920Homeobox_KNKN_HDPFAM
cd00086homeodomainHDCDD
PS50071HOMEOBOX_2HDPROSITE_PROFILES
SSF46689Homeodomain-likeHomeodomain-like_sfSUPERFAMILY
G3DSA:1.10.10.60GENE3D
PTHR11850HOMEOBOX PROTEIN TRANSCRIPTION FACTORSTALE_homeoboxPANTHER

References / Literature

PMID:7651414 - Two-step activation of meiosis by the mat1 locus in Schizosaccharomyces pombe.
Willer M et al. Mol Cell Biol 1995 Sep;15(9):4964-70
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000002 - Comments
PMID:4472733 - Premeiotic DNA synthesis in fission yeast.
Egel R et al. Exp Cell Res 1974 Sep;88(1):127-34
PMID:28228545 - Ablation of RNA interference and retrotransposons accompany acquisition and evolution of transposases to heterochromatin protein CENPB.
Upadhyay U et al. Mol Biol Cell 2017 Apr 15;28(8):1132-1146
PMID:9528784 - The Schizosaccharomyces pombe mei4+ gene encodes a meiosis-specific transcription factor containing a forkhead DNA-binding domain.
Horie S et al. Mol Cell Biol 1998 Apr;18(4):2118-29
PMID:3034608 - The product of the mei3+ gene, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast.
McLeod M et al. EMBO J 1987 Mar;6(3):729-36
PMID:8001162 - Mutations in cyr1 and pat1 reveal pheromone-induced G1 arrest in the fission yeast Schizosaccharomyces pombe.
Davey J et al. Curr Genet 1994 Aug;26(2):105-12
PMID:9191271 - Isolation of yeast mutants hypersensitive to mating pheromones.
Davis K et al. Biochem Soc Trans 1997 May;25(2):227S
PMID:10855500 - Characterization of fission yeast meiotic mutants based on live observation of meiotic prophase nuclear movement.
Hiraoka Y et al. Chromosoma 2000;109(1-2):103-9
PMID:3861929 - Characterization of meiosis-deficient mutants by electron microscopy and mapping of four essential genes in the fission yeast Schizosaccharomyces pombe.
Shimoda C et al. Mol Gen Genet 1985;200(2):252-7
PMID:7499258 - Cloning and functional analysis of the ndk1 gene encoding nucleoside-diphosphate kinase in Schizosaccharomyces pombe.
Izumiya H et al. J Biol Chem 1995 Nov 17;270(46):27859-64
PMID:7975894 - Mating pheromone-induced expression of the mat1-Pm gene of Schizosaccharomyces pombe: identification of signalling components and characterization of upstream controlling elements.
Aono T et al. Yeast 1994 Jun;10(6):757-70
PMID:2328719 - The pat1 protein kinase controls transcription of the mating-type genes in fission yeast.
Nielsen O et al. EMBO J 1990 May;9(5):1401-6
PMID:6948995 - Induction of trehalase activity on a nitrogen-free medium: a sporulation-specific event in the fission yeast, Schizosaccharomyces pombe.
Inoue H et al. Mol Gen Genet 1981;183(1):32-6
GO_REF:0000051 - S. pombe keyword mapping
PMID:8534915 - Schizosaccharomyces pombe zfs1+ encoding a zinc-finger protein functions in the mating pheromone recognition pathway.
Kanoh J et al. Mol Biol Cell 1995 Sep;6(9):1185-95
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:15713656 - Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target.
Kjaerulff S et al. Mol Cell Biol 2005 Mar;25(5):2045-59
PMID:9819418 - The mating-type proteins of fission yeast induce meiosis by directly activating mei3 transcription.
Van Heeckeren WJ et al. Mol Cell Biol 1998 Dec;18(12):7317-26
PMID:2792737 - A mating-type-specific sterility gene map1 is required for transcription of a mating-type gene mat1-Pi in the fission yeast Schizosaccharomyces pombe.
Fujioka H et al. FEMS Microbiol Lett 1989 Jul 01;51(1):45-8
PMID:3025190 - Cloning and analysis of transcription of the mei2 gene responsible for initiation of meiosis in the fission yeast Schizosaccharomyces pombe.
Shimoda C et al. J Bacteriol 1987 Jan;169(1):93-6
PMID:10648609 - Novel WD-repeat protein Mip1p facilitates function of the meiotic regulator Mei2p in fission yeast.
Shinozaki-Yabana S et al. Mol Cell Biol 2000 Feb;20(4):1234-42
PMID:30089908 - Gamete fusion triggers bipartite transcription factor assembly to block re-fertilization.
Vještica A et al. Nature 2018 Aug;560(7718):397-400
PMID:1435723 - Functional conservation between Schizosaccharomyces pombe ste8 and Saccharomyces cerevisiae STE11 protein kinases in yeast signal transduction.
Styrkársdóttir U et al. Mol Gen Genet 1992 Oct;235(1):122-30
PMID:2300054 - Schizosaccharomyces pombe ras1 and byr1 are functionally related genes of the ste family that affect starvation-induced transcription of mating-type genes.
Nadin-Davis SA et al. Mol Cell Biol 1990 Feb;10(2):549-60
PMID:1657709 - Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development.
Sugimoto A et al. Genes Dev 1991 Nov;5(11):1990-9
PMID:1563351 - The ras1 function of Schizosaccharomyces pombe mediates pheromone-induced transcription.
Nielsen O et al. EMBO J 1992 Apr;11(4):1391-5
PMID:2900761 - Four mating-type genes control sexual differentiation in the fission yeast.
Kelly M et al. EMBO J 1988 May;7(5):1537-47