lncRNA gene - sme2 (SPNCRNA.103) - meiosis specific Smp foci lncRNA Sme2 (meiRNA), long isoform OR meiosis specific Smp foci lncRNA Sme2, short isoform

Gene summary

Standard name

sme2

Systematic ID

SPNCRNA.103

Product

meiosis specific Smp foci lncRNA Sme2 (meiRNA), long isoform OR meiosis specific Smp foci lncRNA Sme2, short isoform

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

SPNCRNA.1341, nam4, meiRNA-L, sme2-L, SPNCRNA.4675

Feature type

lncRNA gene

Genomic location

chromosome II: 339346..340907 reverse strand

Annotation

References / Literature

PMID:22582262 - Meiosis-specific noncoding RNA mediates robust pairing of homologous chromosomes in meiosis.

Ding DQ et al. Science 2012 May 11;336(6082):732-6

PMID:24210919 - Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance.

Lee NN et al. Cell 2013 Nov 21;155(5):1061-74

PMID:31533287 - meiRNA, A Polyvalent Player in Fission Yeast Meiosis.

Yamashita A Noncoding RNA 2019 Sep 17;5(3)

PMID:24920274 - Meiotic long non-coding meiRNA accumulates as a dot at its genetic locus facilitated by Mmi1 and plays as a decoy to lure Mmi1.

Shichino Y et al. Open Biol 2014 Jun;4(6):140022

PMID:9778252 - RNA-assisted nuclear transport of the meiotic regulator Mei2p in fission yeast.

Yamashita A et al. Cell 1998 Oct 02;95(1):115-23

PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.

Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515

PMID:21317872 - Red1 promotes the elimination of meiosis-specific mRNAs in vegetatively growing fission yeast.

Sugiyama T et al. EMBO J 2011 Mar 16;30(6):1027-39

PMID:33536434 - A scaffold lncRNA shapes the mitosis to meiosis switch.

Andric V et al. Nat Commun 2021 Feb 03;12(1):770

PMID:20512112 - Importance of polyadenylation in the selective elimination of meiotic mRNAs in growing S. pombe cells.

Yamanaka S et al. EMBO J 2010 Jul 07;29(13):2173-81

PMID:20622014 - Negative regulation of meiotic gene expression by the nuclear poly(a)-binding protein in fission yeast.

St-André O et al. J Biol Chem 2010 Sep 03;285(36):27859-68

PMID:11818066 - 14-3-3 protein interferes with the binding of RNA to the phosphorylated form of fission yeast meiotic regulator Mei2p.

Sato M et al. Curr Biol 2002 Jan 22;12(2):141-5

PMID:26631744 - Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing.

Chalamcharla VR et al. Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15548-55

PMID:23658229 - Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.

Sugiyama T et al. Nucleic Acids Res 2013 Jul;41(13):6674-86

PMID:16823445 - Selective elimination of messenger RNA prevents an incidence of untimely meiosis.

Harigaya Y et al. Nature 2006 Jul 06;442(7098):45-50

PMID:31974447 - Formation of S. pombe Erh1 homodimer mediates gametogenic gene silencing and meiosis progression.

Hazra D et al. Sci Rep 2020 Jan 23;10(1):1034

PMID:35512546 - Structural insights reveal the specific recognition of meiRNA by the Mei2 protein.

Shen S et al. J Mol Cell Biol 2022 Sep 19;14(5)

PMID:41298081 - Gamete fusion triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development.

Araoyinbo A et al. Genes Dev 2025 Nov 26;

PMID:9062192 - Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast.

Watanabe Y et al. Nature 1997 Mar 13;386(6621):187-90

PMID:40185772 - A bifunctional snoRNA with separable activities in guiding rRNA 2'-O-methylation and scaffolding gametogenesis effectors.

Leroy E et al. Nat Commun 2025 Apr 05;16(1):3250

PMID:17032641 - Global roles of Ste11p, cell type, and pheromone in the control of gene expression during early sexual differentiation in fission yeast.

Mata J et al. Proc Natl Acad Sci U S A 2006 Oct 17;103(42):15517-22

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:31811152 - Chromosome-associated RNA-protein complexes promote pairing of homologous chromosomes during meiosis in Schizosaccharomyces pombe.

Ding DQ et al. Nat Commun 2019 Dec 06;10(1):5598

PMID:24493644 - lncRNA recruits RNAi and the exosome to dynamically regulate pho1 expression in response to phosphate levels in fission yeast.

Shah S et al. Genes Dev 2014 Feb 01;28(3):231-44

PMID:7520368 - S. pombe mei2+ encodes an RNA-binding protein essential for premeiotic DNA synthesis and meiosis I, which cooperates with a novel RNA species meiRNA.

Watanabe Y et al. Cell 1994 Aug 12;78(3):487-98

PMID:22522705 - Mmi1 RNA surveillance machinery directs RNAi complex RITS to specific meiotic genes in fission yeast.

Hiriart E et al. EMBO J 2012 May 16;31(10):2296-308

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:23980030 - A novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts.

Yamashita A et al. Nucleic Acids Res 2013 Nov;41(21):9680-7

PMID:9167972 - Microtubule-associated coiled-coil protein Ssm4 is involved in the meiotic development in fission yeast.

Yamashita A et al. Genes Cells 1997 Feb;2(2):155-66

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:34984977 - Functional profiling of long intergenic non-coding RNAs in fission yeast.

Rodriguez-Lopez M et al. Elife 2022 Jan 05;11

PMID:39520300 - Proteins and noncoding RNAs that promote homologous chromosome recognition and pairing in fission yeast meiosis undergo condensate formation in vitro.

Ding DQ et al. FASEB J 2024 Nov 15;38(21):e70163

PMID:33574613 - TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation.

Wei Y et al. Nat Cell Biol 2021 Mar;23(3):243-256

PMID:28841135 - Ubiquitination-dependent control of sexual differentiation in fission yeast.

Simonetti F et al. Elife 2017 Aug 25;6

PMID:39747188 - PhpC NF-Y transcription factor infiltrates heterochromatin to generate cryptic intron-containing transcripts crucial for small RNA production.

Srivastav MK et al. Nat Commun 2025 Jan 02;16(1):268