lncRNA gene - ter1 (SPNCRNA.214) - telomerase RNA

Gene summary

Standard name

ter1

Systematic ID

SPNCRNA.214

Product

telomerase RNA

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

SPNG585, SPNCRNA.884

Feature type

lncRNA gene

Genomic location

chromosome I: 3084610..3086022 reverse strand

Annotation

Orthologs

• TERC (HGNC:11727) Homo sapiens

References / Literature

PMID:26305931 - Telomerase RNA stem terminus element affects template boundary element function, telomere sequence, and shelterin binding.

Webb CJ et al. Proc Natl Acad Sci U S A 2015 Sep 08;112(36):11312-7

PB_REF:0000003 - Disease Association Curation

PMID:29167439 - Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences.

Maestroni L et al. Nat Commun 2017 Nov 22;8(1):1684

PMID:29784772 - A Heterochromatin Domain Forms Gradually at a New Telomere and Is Dynamic at Stable Telomeres.

Wang J et al. Mol Cell Biol 2018 Aug 01;38(15)

PMID:23022480 - Mpn1, mutated in poikiloderma with neutropenia protein 1, is a conserved 3'-to-5' RNA exonuclease processing U6 small nuclear RNA.

Shchepachev V et al. Cell Rep 2012 Oct 25;2(4):855-65

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:29216371 - Fission yeast Ccq1 is a modulator of telomerase activity.

Armstrong CA et al. Nucleic Acids Res 2018 Jan 25;46(2):704-716

PMID:33378677 - Quality-Control Mechanism for Telomerase RNA Folding in the Cell.

Hu X et al. Cell Rep 2020 Dec 29;33(13):108568

PMID:22354040 - RPA facilitates telomerase activity at chromosome ends in budding and fission yeasts.

Luciano P et al. EMBO J 2012 Apr 18;31(8):2034-46

PMID:22101932 - Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast.

Moser BA et al. Nat Struct Mol Biol 2011 Nov 20;18(12):1408-13

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:24210919 - Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance.

Lee NN et al. Cell 2013 Nov 21;155(5):1061-74

PMID:29422503 - LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast.

Mennie AK et al. Nat Commun 2018 Feb 08;9(1):586

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:35277511 - The methyl phosphate capping enzyme Bmc1/Bin3 is a stable component of the fission yeast telomerase holoenzyme.

Porat J et al. Nat Commun 2022 Mar 11;13(1):1277

PMID:18157149 - Identification and characterization of the Schizosaccharomyces pombe TER1 telomerase RNA.

Webb CJ et al. Nat Struct Mol Biol 2008 Jan;15(1):34-42

PMID:22215813 - Schizosaccharomyces pombe Ccq1 and TER1 bind the 14-3-3-like domain of Est1, which promotes and stabilizes telomerase-telomere association.

Webb CJ et al. Genes Dev 2012 Jan 01;26(1):82-91

PMID:29422501 - LARP7 family proteins have conserved function in telomerase assembly.

Collopy LC et al. Nat Commun 2018 Feb 08;9(1):557

PMID:29422664 - Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast.

Páez-Moscoso DJ et al. Nat Commun 2018 Feb 08;9(1):587

PMID:22446625 - Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes.

Tang W et al. Nature 2012 Mar 25;484(7393):260-4

PMID:22302936 - Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast.

Yamazaki H et al. Genes Dev 2012 Feb 01;26(3):241-6

PMID:25131669 - Telomerase activation after recruitment in fission yeast.

Armstrong CA et al. Curr Biol 2014 Sep 08;24(17):2006-11

PMID:29914874 - Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast.

Atkinson SR et al. RNA 2018 Sep;24(9):1195-1213

PMID:18157152 - TER1, the RNA subunit of fission yeast telomerase.

Leonardi J et al. Nat Struct Mol Biol 2008 Jan;15(1):26-33

PMID:31980821 - Nuclear envelope attachment of telomeres limits TERRA and telomeric rearrangements in quiescent fission yeast cells.

Maestroni L et al. Nucleic Acids Res 2020 Apr 06;48(6):3029-3041

PMID:19052544 - Spliceosomal cleavage generates the 3' end of telomerase RNA.

Box JA et al. Nature 2008 Dec 18;456(7224):910-4

PMID:24793650 - Structural basis for protein-RNA recognition in telomerase.

Huang J et al. Nat Struct Mol Biol 2014 Jun;21(6):507-12