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lncRNA gene - mrp1 (SPNCRNA.82) - RNAse MRP

Gene summary

Standard name
mrp1
Systematic ID
SPNCRNA.82
Product
RNAse MRP
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
mrp-1, SPNCRNA.727
Feature type
lncRNA gene
Genomic location
chromosome I: 1234451..1234849 forward strand

Annotation

Comment

PBO:0034716 - 5'-trimethylguanosine cap

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Disease association

MONDO:0054560 - anauxetic dysplasia 1

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MONDO:0009595 - cartilage-hair hypoplasia

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MONDO:0009601 - metaphyseal dysplasia without hypotrichosis

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GO biological process

GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

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GO:0006396 - RNA processing

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GO:0008033 - tRNA processing

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GO cellular component

GO:0000172 - ribonuclease MRP complex

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GO molecular function

GO:0000171 - ribonuclease MRP activity

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001352 - abnormal chromatin organization during vegetative growth

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Genotypes:

FYPO:0003677 - branched, curved, elongated, multiseptate vegetative cell

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Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

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Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

FYPO:0001555 - formation of abnormal tRNA processing intermediates

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Genotypes:

FYPO:0003675 - increased mature 5.8SL rRNA level

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Genotypes:

FYPO:0001406 - increased septum thickness

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002150 - inviable spore population

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000233 - long cytoplasmic microtubules

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Genotypes:

FYPO:0001387 - loss of viability at high temperature

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Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

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Genotypes:

FYPO:0000021 - spheroid vegetative cell

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

Warnings

PBO:0000070 - gene structure updated

Orthologs

References / Literature

PMID:8948095 - Mutational analysis of the gene for Schizosaccharomyces pombe RNase MRP RNA, mrp1, using plasmid shuffle by counterselection on canavanine.
Paluh JL et al. Yeast 1996 Nov;12(14):1393-405
PMID:8887563 - A functional dominant mutation in Schizosaccharomyces pombe RNase MRP RNA affects nuclear RNA processing and requires the mitochondrial-associated nuclear mutation ptp1-1 for viability.
Paluh JL et al. EMBO J 1996 Sep 02;15(17):4723-33
PMID:29914874 - Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast.
Atkinson SR et al. RNA 2018 Sep;24(9):1195-1213
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25401760 - RNase MRP cleaves pre-tRNASer-Met in the tRNA maturation pathway.
Saito Y et al. PLoS One 2014;9(11):e112488
PMID:8553696 - Schizosaccharomyces pombe RNase MRP RNA is homologous to metazoan RNase MRP RNAs and may provide clues to interrelationships between RNase MRP and RNase P.
Paluh JL et al. Yeast 1995 Oct;11(13):1249-64