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lncRNA gene - srp7 (SPNCRNA.98) - 7SL signal recognition particle component

Gene summary

Standard name
srp7
Systematic ID
SPNCRNA.98
Product
7SL signal recognition particle component
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
srp
Feature type
lncRNA gene
Genomic location
chromosome I: 4268662..4268916 forward strand

Annotation

GO biological process

GO:0006614 - SRP-dependent cotranslational protein targeting to membrane

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GO cellular component

GO:0005786 - signal recognition particle, endoplasmic reticulum targeting

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Multi-locus phenotype

FYPO:0000081 - sensitive to high osmolarity

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002133 - abolished protein-RNA interaction

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Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

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Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

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Genotypes:

FYPO:0001645 - decreased protein-protein interaction

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Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

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Genotypes:

FYPO:0001042 - inviable after spore germination, single or double cell division

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000703 - normal protein-protein interaction

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Genotypes:

FYPO:0000081 - sensitive to high osmolarity

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

References / Literature

PMID:25908789 - A new transcription factor for mitosis: in Schizosaccharomyces pombe, the RFX transcription factor Sak1 works with forkhead factors to regulate mitotic expression.
Garg A et al. Nucleic Acids Res 2015 Aug 18;43(14):6874-88
PMID:16453822 - 7SL RNA from Schizosaccharomyces pombe is encoded by a single copy essential gene.
Ribes V et al. EMBO J 1988 Jan;7(1):231-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23221635 - Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle.
Piazzon N et al. Nucleic Acids Res 2013 Jan;41(2):1255-72
PMID:8382769 - Identification of RNA sequences and structural elements required for assembly of fission yeast SRP54 protein with signal recognition particle RNA.
Selinger D et al. Mol Cell Biol 1993 Mar;13(3):1353-62
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:8041618 - Genetic and biochemical analysis of the fission yeast ribonucleoprotein particle containing a homolog of Srp54p.
Selinger D et al. Nucleic Acids Res 1994 Jul 11;22(13):2557-67
PMID:2837648 - Identification of an essential Schizosaccharomyces pombe RNA homologous to the 7SL component of signal recognition particle.
Brennwald P et al. Mol Cell Biol 1988 Apr;8(4):1580-90
PMID:1315954 - Random mutagenesis of Schizosaccharomyces pombe SRP RNA: lethal and conditional lesions cluster in presumptive protein binding sites.
Liao X et al. Nucleic Acids Res 1992 Apr 11;20(7):1607-15
PMID:2837764 - Small ribonucleoproteins in Schizosaccharomyces pombe and Yarrowia lipolytica homologous to signal recognition particle.
Poritz MA et al. Proc Natl Acad Sci U S A 1988 Jun;85(12):4315-9
PMID:8390662 - Functional interchangeability of the structurally similar tetranucleotide loops GAAA and UUCG in fission yeast signal recognition particle RNA.
Selinger D et al. Proc Natl Acad Sci U S A 1993 Jun 15;90(12):5409-13
PMID:31294478 - Senataxin homologue Sen1 is required for efficient termination of RNA polymerase III transcription.
Rivosecchi J et al. EMBO J 2019 Aug 15;38(16):e101955
PMID:2657742 - Genetic analysis of Schizosaccharomyces pombe 7SL RNA: a structural motif that includes a conserved tetranucleotide loop is important for function.
Liao XB et al. Proc Natl Acad Sci U S A 1989 Jun;86(11):4137-41