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snRNA gene - snu4 (SPSNRNA.04) - small nuclear RNA U4

Gene summary

Standard name
snu4
Systematic ID
SPSNRNA.04
Product
small nuclear RNA U4
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
prp13
Feature type
snRNA gene
Genomic location
chromosome II: 467489..467615 reverse strand

Annotation

GO biological process

GO:0045292 - mRNA cis splicing, via spliceosome

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GO cellular component

GO:0005730 - nucleolus

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GO:0005634 - nucleus

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GO:0005687 - U4 snRNP

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Multi-locus phenotype

FYPO:0004742 - normal chromatin silencing at centromere outer repeat

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Genotypes:

Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002346 - abnormal chromatin silencing at centromere outer repeat

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Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

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Genotypes:

FYPO:0003029 - decreased mRNA splicing, via spliceosome

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Genotypes:

FYPO:0003681 - decreased protein level at centromere outer repeat heterochromatin

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Genotypes:

FYPO:0001645 - decreased protein-protein interaction

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Genotypes:

FYPO:0003041 - decreased snRNA splicing

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Genotypes:

FYPO:0000220 - increased centromeric outer repeat transcript level

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Genotypes:

FYPO:0001908 - increased pre-mRNA level

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Genotypes:

FYPO:0002462 - inviable branched, elongated vegetative cell

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Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000228 - lagging mitotic chromosomes

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Genotypes:

FYPO:0003619 - normal mRNA splicing, via spliceosome

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Genotypes:

FYPO:0003620 - normal pre-mRNA level

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Genotypes:

FYPO:0000091 - sensitive to thiabendazole

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Warnings

PBO:0000070 - gene structure updated

References / Literature

PMID:17284461 - Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe.
Hausmann S et al. Nucleic Acids Res 2007;35(5):1411-20
PMID:20400941 - Specific splicing defects in S. pombe carrying a degron allele of the Survival of Motor Neuron gene.
Campion Y et al. EMBO J 2010 Jun 02;29(11):1817-29
PMID:2144896 - Immunoprecipitation distinguishes non-overlapping groups of snRNPs in Schizosaccharomyces pombe.
Tollervey D et al. Nucleic Acids Res 1990 Sep 11;18(17):5207-12
PMID:10445882 - Pac1p, an RNase III homolog, is required for formation of the 3' end of U2 snRNA in Schizosaccharomyces pombe.
Zhou D et al. RNA 1999 Aug;5(8):1083-98
PMID:28765164 - Selective termination of lncRNA transcription promotes heterochromatin silencing and cell differentiation.
Touat-Todeschini L et al. EMBO J 2017 Sep 01;36(17):2626-2641
PMID:2795654 - Schizosaccharomyces pombe U4 small nuclear RNA closely resembles vertebrate U4 and is required for growth.
Dandekar T et al. J Mol Biol 1989 Aug 05;208(3):371-9
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:2192258 - Differential distribution of factors involved in pre-mRNA processing in the yeast cell nucleus.
Potashkin JA et al. Mol Cell Biol 1990 Jul;10(7):3524-34
GO_REF:0000051 - S. pombe keyword mapping
PMID:8809017 - Localization of modified nucleotides in Schizosaccharomyces pombe spliceosomal small nuclear RNAs: modified nucleotides are clustered in functionally important regions.
Gu J et al. RNA 1996 Sep;2(9):909-18
PMID:9003295 - Isolation of novel pre-mRNA splicing mutants of Schizosaccharomyces pombe.
Urushiyama S et al. Mol Gen Genet 1996 Nov 27;253(1-2):118-27
PMID:1441744 - Mutational analysis of Schizosaccharomyces pombe U4 snRNA by plasmid exchange.
Dandekar T et al. Yeast 1992 Aug;8(8):647-53
PMID:20018856 - Involvement of the spliceosomal U4 small nuclear RNA in heterochromatic gene silencing at fission yeast centromeres.
Chinen M et al. J Biol Chem 2010 Feb 19;285(8):5630-8
PMID:42420319 - Spliceosomal proteins direct RNA methylation to modulate gene expression and silence retrotransposons.
Vijayakumari D et al. Nat Commun 2026 Jul 08;
PMID:2806913 - Cloning of Schizosaccharomyces pombe genes encoding the U1, U2, U3 and U4 snRNAs.
Dandekar T et al. Gene 1989 Sep 30;81(2):227-35
PMID:2953599 - Fungal small nuclear ribonucleoproteins share properties with plant and vertebrate U-snRNPs.
Tollervey D et al. EMBO J 1987 Feb;6(2):469-76
PMID:28231281 - The intron in centromeric noncoding RNA facilitates RNAi-mediated formation of heterochromatin.
Mutazono M et al. PLoS Genet 2017 Feb;13(2):e1006606
PMID:34352089 - Co-transcriptional RNA cleavage by Drosha homolog Pac1 triggers transcription termination in fission yeast.
Yague-Sanz C et al. Nucleic Acids Res 2021 Sep 07;49(15):8610-8624