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Haploid genotype - asf1-33(A16T,L61P,E119K,L121P,N156S,E180G aa)

Genotype summary

Description
asf1-33(A16T,L61P,E119K,L121P,N156S,E180G aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
asf1 (SPCC663.05c)histone H3-H4 chaperone Asf1asf1-33A16T,L61P,E119K,L121P,N156S,E180Gamino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0006620 - abnormal chromatin organization during recovery from glucose starvation

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FYPO:0001352 - abnormal chromatin organization during vegetative growth

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FYPO:0002346 - abnormal chromatin silencing at centromere outer repeat

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FYPO:0003247 - abolished histone H3 binding

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FYPO:0000082 - decreased cell population growth at high temperature

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FYPO:0006920 - decreased DNA recombination at mitotic DNA replication fork barriers

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FYPO:0003249 - decreased level of histone H3 at dh repeat

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FYPO:0005288 - decreased negative regulation of transcription by glucose

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FYPO:0001355 - decreased vegetative cell population growth

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FYPO:0003248 - increased level of histone H3 at centromere inner repeat

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FYPO:0000455 - increased number of double-strand break sites during vegetative growth

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FYPO:0000972 - increased number of Rad52 foci during vegetative growth

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FYPO:0001038 - increased protein phosphorylation during vegetative growth

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FYPO:0002411 - inviable curved elongated vegetative cell

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FYPO:0001490 - inviable elongated vegetative cell

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FYPO:0001164 - normal growth on glucose carbon source

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FYPO:0001761 - normal mitotic G1/S phase transition

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FYPO:0003246 - normal mitotic S phase progression

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FYPO:0000783 - protein mislocalized to cytoplasm during vegetative growth

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FYPO:0002578 - resistance to hydroxyurea

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FYPO:0000265 - sensitive to DNA damage

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FYPO:0000089 - sensitive to methyl methanesulfonate

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