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Haploid genotype - bub1-KD(K762R,D900N aa)

Genotype summary

Description
bub1-KD(K762R,D900N aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
bub1 (SPCC1322.12c)mitotic spindle checkpoint kinase Bub1bub1-KDK762R,D900Namino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0004318 - abolished mitotic spindle assembly checkpoint

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FYPO:0001384 - abolished protein kinase activity

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FYPO:0004763 - abolished protein localization to kinetochore during meiosis I

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FYPO:0006455 - abolished protein localization to meiotic spindle during meiosis I

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FYPO:0006456 - abolished protein localization to meiotic spindle during meiosis II

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FYPO:0002033 - abolished protein phosphorylation during vegetative growth

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FYPO:0002577 - decreased chromatin binding

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FYPO:0006423 - decreased meiotic sister chromatid cohesion at centromere during meiosis I

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FYPO:0002825 - decreased protein localization to mitotic spindle

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FYPO:0000228 - lagging mitotic chromosomes

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FYPO:0001687 - normal growth on benomyl

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FYPO:0001164 - normal growth on glucose carbon source

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FYPO:0000091 - sensitive to thiabendazole

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FYPO:0003182 - sister chromatid nondisjunction at meiosis II

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FYPO:0005634 - sister kinetochore dissociation in meiotic metaphase I with equational sister chromatid segregation in meiosis I

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