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Haploid genotype - bub1-KD(K762R,D900N aa) hta1-S121A(S122A aa) hta2-S121A(S122A aa)

Genotype summary

Description
bub1-KD(K762R,D900N aa) hta1-S121A(S122A aa) hta2-S121A(S122A aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
bub1 (SPCC1322.12c)mitotic spindle checkpoint kinase Bub1bub1-KDK762R,D900Namino_acid_mutationNot assayed or wild type
hta1 (SPCC622.08c)histone H2A alphahta1-S121AS122Aamino_acid_mutationNot assayed or wild type
hta2 (SPAC19G12.06c)histone H2A betahta2-S121AS122Aamino_acid_mutationNot assayed or wild type

Annotation

Multi-locus phenotype

FYPO:0004318 - abolished mitotic spindle assembly checkpoint

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FYPO:0006423 - decreased meiotic sister chromatid cohesion at centromere during meiosis I

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FYPO:0002825 - decreased protein localization to mitotic spindle

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FYPO:0000228 - lagging mitotic chromosomes

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FYPO:0001164 - normal growth on glucose carbon source

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FYPO:0000091 - sensitive to thiabendazole

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FYPO:0003182 - sister chromatid nondisjunction at meiosis II

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FYPO:0005634 - sister kinetochore dissociation in meiotic metaphase I with equational sister chromatid segregation in meiosis I

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